A Simple and Rapid Detection of Viral Protein Using RNA Oligonucleotide in a Biosensor

C. Roh, S. Kim, S. Jo, 67(11), 925-929, J Analytical Chemistry, 2012

Current HCV detection methods using ELISA are limited by temperature and condition sensitivity, false negatives, and inability to detect at early stages of infection. In this publication, the authors develop an HCV detection method on the Octet RED system using biotinylated RNA oligonucleotides immobilized on Streptavidin biosensors. The method specifically detected HCV viral protein with high sensitivity (to 500 pg/mL).

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