A PfRH5-Based Vaccine is Efficacious Against Heterologous Strain Blood-Stage Plasmodium Falciparum Infection in Aotus Monkeys

Douglas A, et al., 17(1):130-9, Cell Host Microbe, 2015

This is a proof-of-concept vaccine study performed in Aotus monkeys, a nonhuman primate (NSP) to obtain evidence that it is possible to develop a strain-transcending blood-stage vaccine against Plasmodium falciparum. The in vivo efficacy studies suggest the ability of P. falciparum reticulocyte binding protein homolog 5 (PfRH5) to protect monkeys against malaria. During growth inhibitory activity (GIA50) assays, the IgG concentration in plasma samples were estimated by a Pall ForteBio BLItz instrument equipped with Protein A biosensors.

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