A Human-Infecting H10N8 Influenza Virus Retains a Strong Preference for Avian-Type Receptors

Zhang H, et al., 11;17(3):377-84, Cell Host Microbe, 2015

This work is an attempt to understand the mechanism of human infection and transmission capabilities of the H10N8 virus. These authors determined hemagglutinin (HA) crystal structures with human or avian receptor analogs and investigated receptor-binding properties as well. An Octet RED system equipped with Streptavidin Biosensor probes was used to capture biotinylated avian and human linear glycan receptor analogs, α2-3-sialylated di-N-acetyllactosamine (SLNLN) and α2-6 SLNLN, respectively and to monitor glycan binding specificity of recombinant H10 HA.

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