A Common Solution to Group 2 Influenza Virus Neutralization

Friesen RH, et al., 111(1):445-50, Proc Natl Acad Sci U S A, 2014

In this study, the authors performed structural and functional analysis including electronic microscopy, mutational analysis, ELISA and FACS binding on a newly identified (only the second one) human group 2 type broadly neutralizing antibody (bnAb) to Influenza A viruses. This new bnAb specifically targets residues at the base of the stem region in the major surface glycoprotein hemagglutinin (HA). Binding studies were performed on the Octet RED system to determine KD values using Streptavidin biosensors. This study provides insight into group 2 bnAbs and the potential rationale in designing broader spectrum influenza vaccines.

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