4F Decreases IRF5 Expression and Activation in Hearts of Tight Skin Mice

Xu, H., et al., 7(12):e52046, PLoS One, 2012

This study investigates the effects of 4F (an apoA1 mimetic) on the transcription factor IRF5 in the hearts of Tsk-/+ mice (a murine model of autoimmune disease). IRF5 and 4F interactions were studied using the Octet RED96 system. Biotin-labeled IRF5 was loaded onto Streptavidin biosensors and incubated with 4F protein in PBS to determine rates of association and dissociation.

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