ForteBio - Pioneer SPR Systems

Number of Citations*: 165

Latest Citations: For a complete list, please click here.

Surface Plasmon Resonance: SensiQ Pioneer as a means to screen drug discovery fragments for hits

C Wishart, L Hardy, E Hethershaw… - … of Thrombosis and …, 2015 -

Results The undisclosed enzyme target was incubated with 500µM fragmentǂ in TBST* at 37 C for 10 minutes in a 96-well flat-bottom plate. Hits were screened in duplicate (48 fragments maximum per run at a single concentration). Chromogenic substrate was added …

Cited by 1 Related articles All 3 versions View as HTML

Surface Plasmon resonance–based immunoassays: approaches, performance, and applications

KLM Moran, D Lemass, R O'Kennedy - Handbook of Immunoassay …, 2018 - Elsevier

… SENSIA, Indicator, Fixed angle, Low, Indicator-G, Fixed angle, Low, SensiQ Technologies, Pioneer FE, Wedge beam, Low, Pioneer, Wedge beam, Low, SensiQ, Wedge beam, Low, Discovery, Wedge beam, Low …

Cited by 3 Related articles

Surface plasmon resonance (SPR) studies on the interactions of carotenoids and their binding proteins

P Vachali, B Li, K Nelson, PS Bernstein - Archives of biochemistry and …, 2012 - Elsevier

… Instrumentation. SPR analyses were conducted at 25 °C using a fully automated SensiQ Pioneer optical biosensor equipped with COOH5 sensor chips (ICX Nomadics, Oklahoma City, OK) [24] … Fig. 1. Schematic drawing of SensiQ Pioneer fluidics …

Cited by 29 Related articles All 8 versions


SPR Screening: Applying the New Generation of SPR Hardware

K Narayan, SS Carroll - Applied Biophysics for Drug Discovery, 2017 -

… 6.2 SensiQ Pioneer as a “OneStep” Solution for Hit Identification The typical paradigm for small‐molecule screening (whether it is for FBLD, special- ized libraries, or follow‐up after HTS) is to screen for binding at a single concentra- tion of analyte …

Cited by 1 Related articles All 3 versions

Extracellular fibrinogen-binding protein (Efb) from Staphylococcus aureus inhibits the formation of platelet-leukocyte complexes

MG Posner, A Upadhyay, AA Abubaker… - Journal of Biological …, 2016 - ASBMB

… The SPR signal was recorded in the presence of different concentrations of full-length Efb (100 nm-2.8 μm). All experiments were performed using the SensiQ TM Pioneer FE SPR platform (SensiQ Technologies). Experimental data were fit using the Qdat data analysis software …

Cited by 7 Related articles All 18 versions

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Walkmycin B targets WalK (YycG), a histidine kinase essential for bacterial cell growth

A Okada, M Igarashi, T Okajima, N Kinoshita… - The Journal of …, 2010 -

… The binding affinity of walkmycin B toward WalK (Bs) was assayed with SensiQ Pioneer (ICx Nomadics, Oklahoma City, OK, USA) at 25 °C. The running buffer for the system was 10 mM HEPES (pH 7.4), 150 mM NaCl, 2 mM EDTA, 0.005% (v/v) Tween-20 and 2% (v/v) methanol …

Cited by 54 Related articles All 9 versions


Protein-flavonoid interaction studies by a Taylor dispersion surface plasmon resonance (SPR) Technique: A novel method to assess biomolecular interactions

P Vachali, B Li, B Besch, P Bernstein - Biosensors, 2016 -

Flavonoids are common polyphenolic compounds widely distributed in fruits and vegetables. These pigments have important pharmacological relevance because emerging research suggests possible anti-cancer and anti-inflammatory properties as well other beneficial health effects …

Cited by 6 Related articles All 8 versions Cached


Surface Resonance Sensing Is All the Buzz

K Marusina - Genetic Engineering & Biotechnology News, 2015 -

Pioneer FE is SensiQ's flagship surface plasmon resonance system. It is designed … The innovative injection protocol unique to the SensiQ Pioneer instruments is the OneStep™ method, which exploits Taylor dispersion. The company refers …

Interaction of clusterin and matrix metalloproteinase-9 and its implication for epithelial homeostasis and inflammation

S Jeong, DR Ledee, GM Gordon, T Itakura… - The American journal of …, 2012 - Elsevier

… A solution of CLU-His (R&D Systems, Minneapolis, MN) was prepared in running buffer, and a serial doubling dilution series was prepared according to the SensiQ Pioneer protocol with a top concentration of 100 nmol/L. Each concentration in the series was injected for 3 …

Cited by 51 Related articles All 9 versions


Bayesian Estimation of the Active Concentration and Affinity Constants Using Surface Plasmon Resonance Technology

F Feng, TB Kepler - PloS one, 2015 -

… SPR measurements were carried out on a SensiQ Pioneer biosensor (SensiQ Technologies,Inc., OK) … The enzyme carbonic anhydrase (CAII) and its small molecule inhibitor 4-carboxybenzenesulfonamide (4-CBS) were chosen to be studied on a SensiQ Pioneer biosensor 

Cited by 1 Related articles All 10 versions Cached



Number of Citations*: 165


Latest Citations: For a complete list, please click here.