Clone Screening

Clone screening systems for monoclonality verification and colony picking

Our solutions for antibody discovery and cell line development provide dedicated, scalable, and easy-to-use products for establishing clonal populations. The systems feature a selection of options and models to address your specific research including multiple imaging modes, biology-specific pins, fluidics, and environmental control. These solutions combine intelligent imaging with analysis and automation to increase throughput, consistency, and provide image-based documentation.

  • Verify monoclonality easily

    Objective selection, imaging, and data collection streamlines tracking of colony formation from a single cell.

  • Sort viable single cells efficiently

    High accuracy robotics combined with gentle fluidics-based systems establish viable clones with much higher efficiency.

  • Streamline workflows

    Automation with sample tracking increases throughput, allows for more walk-away time, and provides consistent results.

CloneSelect Single-Cell Printer

QPix 400 Series

Fully automate synthetic biology workflows for DNA assembly, antibody discovery and protein engineering

The QPix® 400 Series Microbial Colony Pickers combine intelligent image analysis with precise automation for fast and efficient screening of large libraries. With a variety of data tracking and assay tools, the QPix Software streamlines the control and management of complex and iterative processes.

QPix 400 Series
    • Automate several sample prep and plate handling processes such as transfer of bacterial liquid culture and plating on agar
    • Streamline your workflow with scalable automation – pick up to 30,000 colonies per day
    • Electronic data tracking for well-documented data control
    • Sterile environment with customizable HEPA filtration options
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ClonePix Series

Automate antibody discovery and cell line development workflows

Screen more clones with the ClonePix® Series in less time with monoclonal verification on day zero, then screen and pick for highest producers in weeks, not months.

ClonePix Series
    • Screen 10X more clones than limiting dilution
    • Increase probability of identifying high-value clones
    • Condense the workflow into a single solution
    • Eliminate or recover unstable clones early
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CloneSelect Imager and CloneSelect Imager FL

Verify monoclonality confidently

The all-new CloneSelect Imager FL adds high contrast multichannel fluorescent technology in addition to the standard white light imaging that allows for accurate single-cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.

CloneSelect Imager FL
    • Document evidence of single cells and confluency digitally for auditing and submission to regulatory authorities
    • Image cells non invasively at multiple time points to monitor colony formation
    • Screen using high resolution white light imaging
    • Deliver real-time results with on-the-fly analysis
    • Automation and integration ready
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CloneSelect Single-Cell Printer††

Demonstrate monoclonality with greater confidence

The CloneSelect™ Single-Cell Printer™ (SCP series) by Cytena and Molecular Devices is a fully automated system that utilizes proprietary microfluidics-based technology and real-time image analysis to sort and deposit single cells into standard microplates—while simultaneously providing assurance of monoclonality through image documentation.

CloneSelect Single-Cell Printer

††Only available in North America, China, Hong Kong, and Taiwan

    • Confidently isolate single cells and provide consistent, high-quality image evidence of monoclonality to the FDA
    • Highly efficient single-cell sorting with an average printing efficiency > 80% observed when using CHO cells and HEK 293 cells
    • Achieve comparable high cell viability to limiting dilution method by gentle handling cells
    • Minimize cross contamination through disposable cell printing cartridges
    • Fast turnaround time—prints a 96-well plate within 5-10 minutes
    • Sort wide range of cell lines: CHO, HEK, SF9, iPSC, primary cells
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Applications & Research

Find an extensive collection of application notes, research, and workflows related to clone screening including cell line development, antibody discovery, and more.