Our solutions for antibody discovery and cell line development provide dedicated, scalable, and easy-to-use products for establishing clonal populations. The systems feature a selection of options and models to address your specific research including multiple imaging modes, biology-specific pins, fluidics, and environmental control. These solutions combine intelligent imaging with analysis and automation to increase throughput, consistency, and provide image-based documentation.
Objective selection, imaging, and data collection streamlines tracking of colony formation from a single cell.
High accuracy robotics combined with gentle fluidics-based systems establish viable clones with much higher efficiency.
Automation with sample tracking increases throughput, allows for more walk-away time, and provides consistent results.
Introducing DispenCell Single-Cell Dispenser
The QPix® 400 Series Microbial Colony Pickers combine intelligent image analysis with precise automation for fast and efficient screening of large libraries. With a variety of data tracking and assay tools, the QPix Software streamlines the control and management of complex and iterative processes.
Screen more clones with the ClonePix® Series in less time with monoclonal veriﬁcation on day zero, then screen and pick for highest producers in weeks, not months.
The all-new CloneSelect Imager FL adds high contrast multichannel fluorescent technology in addition to the standard white light imaging that allows for accurate single-cell detection and proof of monoclonality at day 0. Streamline your workflow with comparative confluence assays to identify and verify gene edits.
The DispenCell Single-Cell Dispenser is an automated laboratory instrument designed for fast, easy, and gentle single-cell isolation. Cell dispensing technology enables scientists to isolate single cell lines three times faster and at a lower cost compared to existing solutions.
Find an extensive collection of application notes, research, and workflows related to clone screening including cell line development, antibody discovery, and more.
Monoclonality is term that describes a cell line that originates from a single progenitor (single cell) - and is therefore monoclonal. Cell line development and assurance of monoclonality are critical steps in the process of generating biopharmaceutical molecules, such as monoclonal antibodies.
Monoclonal antibodies (mAbs) originate from one unique parent cell, thus binding only to a single epitope. Monoclonal antibody discovery typically refers to the screening and identification of specific antibodies that target a specific epitope for the diagnosis and treatment of diseases, like the coronavirus for COVID-19.
Synthetic biology is a broad term that refers to the manipulation of genetic pathways to harness the power of existing biological systems in novel ways (often to manufacture molecules or proteins). Synthetic biology applies principles that are derived from engineering, specifically design-build-test-learn cycles, to biological systems. By leveraging high-throughput workflows, synthetic biologists can accelerate this process.
Mammalian and microbial clone screening projects traditionally begin with a target—a receptor, protein, or gene that participates in a biological pathway of interest. Next comes screening, where thousands to millions of cells are tested and analyzed in relation to the target. This presents a significant bottleneck for labs as it requires laborious and time-consuming methods across a wide range of analytical platforms.
View our complete line of clone screening systems along with an assortment of high-performance media and labware. We also offer services for instrument customizations and robotics.
Inscripta enables scientists to perform digital genome editing with their Onyx system integrated in a fully automated workflow that includes the QPix systemCase study
The Fred Hutch Cancer Research Center uses the ClonePix 2 system to efficiently screen and isolate positive hybridoma clonesCase study
Harvard Medical School uses the QPix colony pickers to map networks of macromolecular interactions to help understand phenotype to gene relationshipCase study
Zymergen uses the QPix colony pickers to make better microbes in industrial fermentationCase study
University of Edinburgh uses QPix colony pickers to scale up DNA manufacturingCase study