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Patch-Clamp Microelectrode Amplifier Comparison Chart

Features
Applications
Smart telegraph
Seal test
Holding potential range
Holding current range
Output gain (mV/pA)
Modes
Open circuit noise in 5kHz and 10 kHz
True voltage clamp-resistor feedback
Capacitance Compensation
RMS Noise
Automatic oscillation suppression
Automated mode-switching between current clamp and voltage clamp mode
Slow current injection to maintain assigned potential
True current clamp-voltage follower
Simultaneous dual patch clamping recordings
Computer control: Holding level, current passing, filter option, multiple signal outputs, pipette offset, fast and whole cell capacitance compensation, series compensation, pipette neutralization, bridge balance
Conventional Interface
Applications
Single-channel recording, whole-cell patch-clamp recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study
Smart telegraph
Gain, filter, capacitance
Seal test
Holding potential rangeHolding potential range
-/+ 1000 mV
Holding current range
-/+ 200 nA
Output gain (mV/pA)
0.5 to 500
Modes
I-Clamp, V-Clamp
Open circuit noise in 5kHz and 10 kHz
0.06 pA rms, (5 kHz), 0.13 pA rms (10 kHz)
True voltage clamp-resistor feedback

for cSEVC
Capacitance Compensation
RMS Noise
0.13 pA rms (10 kHz) increases to only 0.145 pA RMS when a patch-pipette holder is attached
Automatic oscillation suppression
Automated mode-switching between current clamp and voltage clamp mode
Slow current injection to maintain assigned potential
True current clamp-voltage follower
Simultaneous dual patch clamping recordings
Computer control: Holding level, current passing, filter option, multiple signal outputs, pipette offset, fast and whole cell capacitance compensation, series compensation, pipette neutralization, bridge balance
Conventional Interface
Applications
Single-channel recording, whole-cell patch-clamp recording, intracelluar sharp electrode recording, extracellular recording, amperometry/voltammetry, bilayer recording, nanopore study
Smart telegraph
Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
Seal test
Holding potential rangeHolding potential range
-/+ 1000 mV
Holding current range
-/+ 200 nA
Output gain (mV/pA)
1.0 to 2000
Modes
I-Clamp, V-Clamp
Open circuit noise in 5kHz and 10 kHz
0.15 pA rms, (5 kHz), 0.28 pA rms (10 kHz)
True voltage clamp-resistor feedback

for cSEVC
Capacitance Compensation
RMS Noise
0.28 pA rms (10 kHz) at 50 GΩ to 3.0 pA rms (10 kHz) at 50 MΩ
Automatic oscillation suppression
Automated mode-switching between current clamp and voltage clamp mode
Slow current injection to maintain assigned potential
True current clamp-voltage follower
Simultaneous dual patch clamping recordings
Computer control: Holding level, current passing, filter option, multiple signal outputs, pipette offset, fast and whole cell capacitance compensation, series compensation, pipette neutralization, bridge balance
Conventional Interface

with SoftPanel Controller
Applications
Whole-cell current-clamp recording, intracelluar sharp electrode recording, extracellular recording, two-electrode voltage-clamp recording
Smart telegraph
Gain, filter, capacitance, input/output scaling factors, recording mode - 2 channels
Seal test
Holding potential rangeHolding potential range
-/+ 200 mV for dSEVC and TEVC modes
Holding current range
Up to -/+ 1/Ro (feedback resistor)
Output gain (mV/pA)
1.0 to 2000
Modes
I-Clamp, DCC, HVIC, dSEVC, TEVC
Open circuit noise in 5kHz and 10 kHz
N/A
True voltage clamp-resistor feedback

for dSEVC
Capacitance Compensation

(but not for whole-cell)
RMS Noise
20 mV at 10 kHz
Automatic oscillation suppression
Automated mode-switching between current clamp and voltage clamp mode

Switch from I-clamp to dSEVC and TEVC mode
Slow current injection to maintain assigned potential
True current clamp-voltage follower
Simultaneous dual patch clamping recordings
Computer control: Holding level, current passing, filter option, multiple signal outputs, pipette offset, fast and whole cell capacitance compensation, series compensation, pipette neutralization, bridge balance
Conventional Interface

with SoftPanel Controller