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pCLAMP 11 Software Suite

Sophisticated patch-clamp electrophysiology data acquisition and analysis software
Patch-clamp analysis software with Clampfit Advanced Analysis Module
The pCLAMP™ Software Suite is an industry-leading patch-clamp electrophysiology data acquisition and analysis program for the control and recording of voltage-clamp, current-clamp, and patch-clamp experiments. The software suite consists of Clampex 11 Software for data acquisition, AxoScope 11 Software for background recording, Clampfit 11 Software for data analysis, and optional Clampfit Advanced Analysis Module for sophisticated and streamlined analysis.
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Design advanced protocols easily
The enhanced protocol editor enables up to 50 epochs instead of 10, providing the flexibility to program longer, more sophisticated protocols.
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Streamline workflows*
Batch analysis macros enable the analysis of data files in batches and eliminates the need to define parameters for every data set.
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Analyze faster*
Automated event detection analyzes spontaneous and evoked action potentials and post-synaptic data. Identify events based on a variety of factors.
pCLAMP 11
Features
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Comprehensive analysis tools
The software includes a wealth of analysis tools including 24 cursor pairs for regions of interest search, graph plotting tools such as I-V plot and histogram, and more.
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Improved visualization
The membrane testwindow displays up to eight channels simultaneously, making it easier to control multiple channels.
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Enhanced gap-free mode
A simple continuous "chart-recorder" useful for monitoring single channel events, minis, and other spontaneous activities. Protocol-editor-style epochs and program digital or analog outputs can be executed.
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Population spike analysis*
This tool automatically calculates amplitude, area under the curve, half-width, decay and rise time, decay and rise slope, coastline of spike, and paired pulses.
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Action potential analysis*
This feature automatically detects and analyzes amplitude, APD90, rise and decay time, rise and decay slope, peak-to-peak frequency and time, and more.
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Batch analysis*
Macros for batch analysis eliminates the need to define parameters for every data set. Saved macros can be applied to multiple data sets for automatic analysis.
*Clampfit Advanced Analysis Module only
Latest Resources
Specifications & Options of pCLAMP 11 Software Suite
*Supports all previous versions in a model line.
**We only support Professional, Enterprise, and Ultimate editions but not Home edition.
Axon™ pCLAMP®, Axon™ DigiData™ and Windows Operating System Compatibility Table
Consult the table below to determine pCLAMP software compatibility with various AXON digitizers and Windows operating systems.
pCLAMP |
MiniDigi |
DigiData 1200 |
DigiData 132x |
DigiData 1440 |
Digidata 1550 series |
Windows OSa |
8.xb |
No |
Yes |
Yes |
No |
No |
95, 98, ME, NT4.0, 2000, XP |
9.xc |
Yes |
Yes |
Yes |
No |
No |
98, ME, 2000, XP |
10.xd |
Yesh |
No |
Yesg |
Yesf |
Yesf |
2000, XP sp3, Vista, Windows 7 & Windows 10e (32 & 64-bit) |
11.x |
Yesh |
No |
No |
Yes |
Yes |
Windows 7 & Windows 10e (32 & 64-bit) |
Notes:
a.) Only U.S. versions of Windows operating systems are fully supported, and only a computer with authentic Windows is supported, i.e., emulators and virtual machines are not supported. pCLAMP version 10.3 or higher are the only installers that support 64-bit Operating Systems.
b.) Update from 8.0 or 8.1 to 8.2 is free. Only the 32-bit installer of 8.2 runs on Windows XP (see download link above).
c.) Update from 9.0 or 9.1 to 9.2 is free. pCLAMP 9 software is not supported for use under Windows 7 (32- or 64-bit versions).
d.) All updates within 10.x (e.g. from 10.0 to 10.7) are free.
e.) Windows Home Edition is not supported.
f.) Digidata 1440, 1550, 1550A, and 1550B are supported on 10.7.
g.) Use of the Digidata 1320A, 1321A or 1322A on 64-bit Operating Systems is not supported. The Digidata 132x series are only supported up to pCLAMP versions 10.3.
h.) MiniDigi 1B is required for use under 64-bit Operating Systems.
Resources of pCLAMP 11 Software Suite
Customer Breakthrough
University of Michigan use our Axon instruments to investigate NMDAR receptor blockers
University of Michigan use our Axon instruments to investigate NMDAR receptor blockers
NMDAR ion channels are found in neurons and are frequent targets of research efforts. In addition to potentially playing a key role in learning and memory, it is also a target for re…
Customer Breakthrough
York University uses Axon Patch-Clamp instruments to investigate the roles of pannexin channels in epilepsy
York University uses Axon Patch-Clamp instruments to investigate the roles of pannexin channels in epilepsy
The Zoidl lab at York University, Canada, investigates the roles of pannexin channels in the nervous system in both physiological and pathological contexts, primarily using z…
Brochure
Action your Potential
Action your Potential
The Axon Instruments® portfolio provides comprehensive solutions for patch-clamping that includes amplifiers, digitizer, software, and accessories.
Customer Breakthrough
Allegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease
Allegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease
Dr. Lauren French is working with undergraduate students at Allegheny College to find out how the amyloid beta peptide implicated in Alzheimer’s disease pathology inhibits a calcium-…
User Guide
The Axon™ Guide
The Axon™ Guide
The Axon Guide, a guide to electrophysiology and Biophysics laboratory techniques
Customer Breakthrough
University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall
University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall
The goal of these studies is to identify mechanisms that are amenable to therapeutics and therefore applicable for preventing memory loss. Dr. Krishnan investigates differential phos…
Data Sheet
Axon pCLAMP 11 Software Suite
Axon pCLAMP 11 Software Suite
The Axon™ pCLAMP™ Software Suite from Molecular Devices is the most widelyused electrophysiology data acquisition and analysis program for control and recording of voltage-clamp, cur…

A complete workflow solution for patch-clamp electrophysiology
For the latest featured videos, webinars and tutorials on our Axon instrument solution including Axon Patch-clamp Amplifiers, Digidata 1550B Digitizer plus HumSilencer, and pCLAMP Software Suite, visit our Axon Patch-Clamp Video Gallery.

Discover what's new in our Axon Guide

Tech Tips with Jin Yan: User List in Clampex 11

Streamlining electrophysiology data acquisition and analysis in ion channel study with Axon pCLAMP 11 software

Enhance your Electrophysiology studies with Axon pCLAMP 11 Software

Speed up precise data measurements with pCLAMP 11

Empower electrophysiology data analysis with new Clampfit 11 Advanced Event

Empower your electrophysiology studies using new Axon pCLAMP 11 software

Tech Tips with Jin Yan: Sequencing Keys

Tech Tips with Jin Yan: Increasing the number of epochs in Clampex 11

Tech Tips with Jin Yan: Protocol Length in Clampex 11

Save your time on data analysis with new Batch Analysis feature in Axon pCLAMP 11 Software

Tech Tips with Jeffrey Tang: Axon pCLAMP™ 11 Software Feature for Batch Analysis

Tech Tips with Jin Yan: Axon pClamp™ 11 Software Feature for Action Potential Analysis

Using Electrophysiology Studies to Accelerate Mechanistic Study in Reception and Transmission
pCLAMP 11

Enhanced Protocol Editor in pCLAMP 11

Population Spike Analysis in pCLAMP 11

Batch Data Analysis Macros

Neuronal Action Potential Analysis

How to Combine Traces, Calculate Rise or Decay Time Constant, and Perform Curve Fitting Using Axon pCLAMP Software

Update and Hardware Choices for Optogenetics Considerations for Synchronized Light Patterning

Investigations of the Effects of Amyloid-Beta Proteins on hSlo1.1, a BK Channel, in a Xenopus Oocyte Model

Nanopores-Electronic Tools for Single-Molecule Biophysics and Bio-Nanotechnologies
Number of Citations*: 47,900
Latest Citations: For a complete list, please click here .
*Source: https://scholar.google.com/
- Dated: Jan 12, 2021
Analyzing of neural discharge signal with PCLAMP software
By means of data sampling interface and analysis software of PCLAMP microcomputer processing system, Neural discharge signal was sampled and analyzed. Xetting some parameters of sampling parameter's table and analysis parameter's table of FETCHEX,neural discharge signal was Xampled,and analyzed the signal automatically.Using this method ,the… View moreBy means of data sampling interface and analysis software of PCLAMP microcomputer processing system, Neural discharge signal was sampled and analyzed. Xetting some parameters of sampling parameter's table and analysis parameter's table of FETCHEX,neural discharge signal was Xampled,and analyzed the signal automatically.Using this method ,the neural discharge in rostral ventrolateral medulla in rat was analyzed, the result was satisfactory.
Contributors: WANG Min-yan ,YI Xiao-lin ,MENG Yan-jun, FAN Zhen-zhong (Institute of Basic Nursing, Hebei Medical University, Xhijiazhuang 050017,China)
Go to article - Dated: Oct 01, 2000Publication Name: Acta Physiologica Sinica
Analysis of P/N leak subtraction of pClamp acquisition software
Using blind whole cell recording technique on rat hippocampal slices, the function and mechanisms of P/N leak subtraction of Clampex program in pClamp acquisition software were studied. The ways of picking up sub-pulse current and properly selecting parameters, including time course, polarization, sub-holding potential, numbers and location of P/N… View moreUsing blind whole cell recording technique on rat hippocampal slices, the function and mechanisms of P/N leak subtraction of Clampex program in pClamp acquisition software were studied. The ways of picking up sub-pulse current and properly selecting parameters, including time course, polarization, sub-holding potential, numbers and location of P/N sub-pulse were analyzed in detail. Our results indicate that voltage-gated ion channel currents recorded by Clampex will be more accurate and reproducible by properly using P/N leak subtraction.
- Dated: Jun 01, 1989Publication Name: American Physiological Society
Inward-rectifying potassium channels in rat hepatocytes
The patch-clamp technique has been used to investigate single-channel and whole cell conductances in freshly isolated rat hepatocytes. Whole cell experiments, with high (144 mM) intracellular and extracellular potassium as the principal conductive species, show some variation between cells in the current-voltage relationship (mean whole-cell… View moreThe patch-clamp technique has been used to investigate single-channel and whole cell conductances in freshly isolated rat hepatocytes. Whole cell experiments, with high (144 mM) intracellular and extracellular potassium as the principal conductive species, show some variation between cells in the current-voltage relationship (mean whole-cell conductance at physiological potentials being 2.7 nS). This may suggest functional heterogeneity of cells. The most common finding is that the current-voltage relationship shows inward rectification. This is reflected in cell-attached single-channel recordings in which channels displaying strong inward rectification and K+ selectivity are seen. The channels show a mean inward conductance (with 144 mM potassium in the pipette) of 44 pS and an outward conductance of 23 pS. The open probability is not voltage dependent, and the channels do not exhibit calcium dependence. The channels are quite different from others described in hepatocytes, but they show marked similarities to channels recently described in renal epithelial cells. Current-voltage relationships in the whole cell mode exhibit an increase in slope conductance at large hyperpolarizing and depolarizing potentials.
Related Products & Services of pCLAMP 11 Software Suite
Customer Breakthrough


SUCCESS STORY
University of Michigan use our Axon instruments to investigate NMDAR receptor blockers
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Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
I’d like to…
How can we help advance your next big discovery?
Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
I’d like to…