The Axon™ Digidata® 1550B plus HumSilencer® is one of the most advanced analog-to-digital signal converters on the market, offering the innovative line synchronous noise-cancelling feature, HumSilencer. This advanced feature learns, adapts, and eliminates local 50/60 Hz line-frequency noise and high-frequency harmonics from incoming signals. The digitizer works with pCLAMPTM 11 Software for data acquisition and analysis. The software supports eight channels of analog acquisition and four acquisition modes.
HumSilencer removes 50/60 hz line-frequency noise on up to four channels in parallel. The function is quickly enabled through a software checkbox.
All eight analog input channels can be simultaneously digitized at an impressive sampling rate of 500 kHz per channel.
With Digidata 1550B system, you can now record cellular networks without 50/60 Hz line-frequency noise in a single digitizer while saving money, time, and reducing hassle.
Introducing the Axon Digidata 1550B Low Noise Data Acquisition System plus HumSilencer
HumSilencer is an advanced feature that learns, adapts, and eliminates local 50/60 Hz line-frequency noise patterns and associated high-frequency harmonics from incoming signal up to 20 V peak-to-peak.
HumSilencer is not a filter and has no effect on acquired signals. It causes no signal distortion such as frequency change, amplitude attenuation, phase shift, or DC voltage change.
Digidata 1550B digitizes a wide range of input signals from -10 to +10 V.
HumSilencer automatically recognizes changes in noise amplitudes and adapts by removing noise in less than one second.
The pCLAMP Software suite is the most widely-used patch-clamp electrophysiology data acquisition and analysis program for control and recording of voltage-clamp, current-clamp, and patch-clamp experiments.
Three configurations are available: Digidata 1550B4 with four HumSilencer channels, Digidata 1550B1 with one HumSilencer channel, and Digidata 1550B0 without a HumSilencer channel.
Videos & Webinars
Learn how to concatenate traces, calculate inactivation time constant tau, and plot current-voltage curves in the Clampfit module of the pCLAMP software. Click here to…
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, and neuronal communications.
The current or voltage signal acquired by the amplifier is an analog signal, but to perform data analysis needed for high resolution patch-clamp measurements, the analog signal must be converted into a digital one. Positioned between the amplifier and the computer, the digitizer accomplishes this important task. Signal quality is extremely important and is impacted by the sampling frequency. The latest generation of Digidata digitizers sample at 500 kHz and can be equipped with HumSilencer, which eliminates 50/60 Hz line-frequency noise.
Ion channels play a role in many diseases including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain, and cancer. By understanding the exact role that ion channel play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease.
50/60 Hz line-frequency noise, also known as electrical hum, is the most common source of background noise in patch-clamp electrophysiology experiments. This noise can overwhelm biological signals of interest, making sensitive patch-clamp measurements nearly impossible. Traditional trouble shooting is typically only partially effective and can impair data accuracy. HumSilencer is a filter-free, adaptive technology that learns and removes line frequency noise without using methods that impair signal accuracy like filters, that can distort biological signals.
NMDAR ion channels are found in neurons and are frequent targets of research efforts. In addition to potentially playing a key role in learning and memory, it is also a target for re…
The Zoidl lab at York University, Canada, investigates the roles of pannexin channels in the nervous system in both physiological and pathological contexts, primarily using z…
The Axon Instruments® portfolio provides comprehensive solutions for patch-clamping that includes amplifiers, digitizer, software, and accessories.
A major challenge within electrophysiology research is 50 or 60 Hz line frequency electrical noise, which can either distort or completely drown out the biological signal the researc…
Get details about Axon Digidata 1550B Low-Noise Data Acquisition System plus HumSilencer.
Dr. Lauren French is working with undergraduate students at Allegheny College to find out how the amyloid beta peptide implicated in Alzheimer’s disease pathology inhibits a calcium-…
Get an overview of Axon Digidata 1550 Data Acquisition System which is designed for electrophysiology experiments, to send & receive signals from microelectrode amplifiers.
The Axon Guide, a guide to electrophysiology and Biophysics laboratory techniques
The goal of these studies is to identify mechanisms that are amenable to therapeutics and therefore applicable for preventing memory loss. Dr. Krishnan investigates differential phos…
Explore this Axon Axoclamp 900A Microelectrode Amplifier datasheet. this instrument offers several modes of operation that measure signals from single cells, tissue slices and whole…
Learn about MultiClamp 700B Amplifier for electrophysiology and electrochemistry which is capable of single-channel & whole-cell voltage patch clamp, and much more.
Download datasheet to learn about Axon Axopatch 200B Microelectrode Amplifier which includes cooling of the active elements to achieve the lowest possible electrical noise.
To rapidly and effectively eliminate line frequency noise, Molecular Devices has developed the next generation of digitizers—the Axon™ Digidata® 1550 Series Low-Noise Data Acquisition…
In this application note, we have answered many of the questions and concerns of using HumSilencer to remove line frequency interference without distorting the biological signals…
This guide provides information about the Patch-Clamp Rig. It is an important electrophysiology technique with a broad range of applications.
For the latest featured videos, webinars and tutorials on our Axon instrument solution including Axon Patch-clamp Amplifiers, Digidata 1550B Digitizer plus HumSilencer, and pCLAMP Software Suite, visit our Axon Patch-Clamp Video Gallery.
Discover what's new in our Axon Guide
Save your time on data analysis with new Batch Analysis feature in Axon pCLAMP 11 Software
Introducing the Axon Digidata 1550B Low Noise Data Acquisition System plus HumSilencer
How to Combine Traces, Calculate Rise or Decay Time Constant, and Perform Curve Fitting Using Axon pCLAMP Software
Using Electrophysiological Studies to Accelerate Mechanistic Study in Reception and Transmission
Update and Hardware Choices for Optogenetics Considerations for Synchronized Light Patterning
Investigations of the Effects of Amyloid-Beta Proteins on hSlo1.1, a BK Channel, in a Xenopus Oocyte Model
Nanopores-Electronic Tools for Single-Molecule Biophysics and Bio-Nanotechnologies
|Axoclamp 900A Headstage HS-9A X0.1U||x0.1 headstage||1-2950-0359|
|Axoclamp 900A Headstage HS-9A X1U||x1 headstage||1-2950-0360|
|Axoclamp 900A Headstage HS-9A X10U||x10 headstage||1-2950-0361|
|Axoclamp 900A Headstage VG-9A X10U||x10 virtual ground headstage||1-2950-0362|
|Axoclamp 900A Headstage VG-9A X100U||x100 virtual ground headstage||1-2950-0363|
|MultiClamp 700B Headstage CV-7B||Patch-clamp headstage||1-CV-7B|
|MultiClamp 700B Headstage CV-7B/BL||Bilayer headstage||1-CV-7B/BL|
|MultiClamp 700B Headstage CV-7B/EC||Electrochemistry headstage||1-CV-7B/EC|
Electrode holders, adapters, and holder components
|Electrode Holder for U-Type Headstages||Fits glass pipettes with outer diameter of 1.0 - 1.7 mm||1-HL-U|
|Electrode Holder Replacement Caps||Set of 2 polycarbonate caps for HL-U holders||1-HL-CAP|
|Cone Washers 1.1mm ID||Set of 10 orange cone washers for HL-U holders, fit glass with outer diameter of 1.0 - 1.1 mm||1-HLC-11|
|Cone Washers 1.3mm ID||Set of 10 orange cone washers for HL-U holders, fit glass with outer diameter of 1.1 - 1.3 mm||1-HLC-13|
|Cone Washers 1.5mm ID||Set of 10 orange cone washers for HL-U holders, fit glass with outer diameter of 1.3 - 1.5 mm||1-HLC-15|
|Cone Washers 1.7mm ID||Set of 10 orange cone washers for HL-U holders, fit glass with outer diameter of 1.5 - 1.7 mm||1-HLC-17|
|Pins 1mm for HL-U Holders||Set of 3 brass pins for HL-U holders, 1mm||1-HLP-U|
|2mm Plugs with Solder Cups||Set of 5 general purpose gold plugs, 2mm, with solder cups||1-HLP-0|
|Silver Wire||Set of 5 Ag wires, 0.25mm diameter, 50mm long||1-HLA-005|
|Silicone Tubing for Silver Wire||1mm ID x 70mm Long Silicone Tubing||1-HLT-70|
|Silver/Silver Chloride Pellet Assemblies||Set of 3 Ag/AgCl pellet assemblies||1-HLA-003|
|Adapter For BNC Holders To U-Type Headstages||Connects BNC holders to CV and HS headstages with threaded collets (U-type)||1-HLB-U|
|Right-Angle Adapter for HL-U Electrode Holders||Fits CV and HS headstages with threaded collets (U-type)||1-HLR-U|
|Model Cell for Oocytes||Axoclamp/ GeneClamp model cell for oocytes. Connects to U-type HS series headstages||1-MCO-2U|
|Model Cell for TEVC / DSEVC||Axoclamp/ GeneClamp model cell for two-electrode voltage clamp/ discontinuous single-electrode voltage-clamp conditions. Connects to U-type HS series headstages||1-CLAMP-1U|
|Model Cell for Whole Cell/ Single Channels||Axopatch/ GeneClamp/ MultiClamp model cell for whole-cell / single-channel patch-clamp conditions. Connects to U-type CV series headstages||1-PATCH-1U|
|Model Cell for Bilayers||Axopatch/ GeneClamp/ MultiClamp model cell for bilayer conditions. Connects to U-type CV series headstages||1-MCB-1U|
|Cable To Connect Axoclamp 2 Headstages To Axoclamp 900A Amplifier||Allows Axoclamp 2 headstages (HS-2, VG-2) to be used on Axoclamp 900A Amplifiers||1-2100-0934|
|SoftPanel Amplifier Control Unit||Provides physical knob and button control for computer-controlled Axoclamp 900-series and MultiClamp 700-series amplifiers. Requires a USB connection.||1-SOFTPANEL (USB)|
|Remote Buzz For Axoclamp 900A||Hand-held buzz duration control for Axoclamp 900A Amplifier (1-50ms)||1-2950-0366|
|Silver/Silver Chloride Pellet Assemblies||Set of 3 Ag/AgCl pellet assembly and Ag wire||1-HLA-003|