Systems for whole cell patch-clamp, extracellular, and single-channel recordings
The Axon Instruments® portfolio provides comprehensive solutions for patch-clamping that includes amplifiers, digitizer, software, and accessories. Our best-in-class instruments facilitate the entire range of patch-clamp technique experiments from the smallest single-channel to the largest macroscopic recordings. With the addition of Axon™ pCLAMP™ 11 Software Suite for acquisition, recording and analysis, a truly streamlined workflow is realized.
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Eliminate line-frequency noise
The HumSilencer™ feature removes 50/60 hz line-frequency noise on up to four channels in parallel. The function is quickly enabled through a software checkbox.
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Maximize signal-to-noise ratio
The Axopatch™ 200B Amplifier offers one of the lowest-noise, single-channel recordings available via an innovative actively cooled headstage with capacitor-feedback technology.
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Streamline workflows
pCLAMP Software offers a selection of modules and tools that simplifies setup and enables automation of parameters.
pCLAMP 11
A complete workflow solution for patch-clamp electrophysiology
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Amplification—amplify your success
- Control via pCLAMP software maximizes flexibility in setting up and performing different experimental protocols
- A wide range of amplifiers means we can offer the ideal choice for your application, providing the best possible data
- Our lowest-noise amplifier/digitizer instruments provide the highest signal resolution, and eliminate 50 or 60 Hz line-frequency noise contamination
Axon Instruments Patch-Clamp Amplifiers
The Axon™ Digidata® 1550B plus HumSilencer®
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Digitization—get better data, faster
- High rate of sampling (500kHz) means a more faithful digitization process, allowing for precise digital reconstruction of the analogue signal due to minimal information loss
- Eight channels can be sampled and digitized simultaneously, increasing data acquisition speed
- The HumSilencer option with the Digidata range eliminates of 50 and 60Hz line-frequency noise, making the biological signal clearer without distorting the data
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Acquisition — get more flexibility and easier acquisition
- Enhanced protocol editor in pCLAMP 11 Software allows for longer and more sophisticated protocols to be programmed and reduces protocol setup time
- Multiple windows can be simultaneously displayed during a Membrane Test protocol, making it easier to patch multiple cells
- Gap-free mode allows the programming of command and digital outputs in a continuous recording, allowing you to enhance protocol design and trigger actions within the protocol automatically
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Analysis—discover more while saving time
- Acquisition and analysis are combined in one package, streamlining the entire process
- Advanced modules allow action potential and population spike measurements to be made automatically
- New Batch Analysis feature allows multiple datasets to be analysed using an identical macro; saving time on data analysis and ensuring the exact same analysis is carried out on each dataset
pCLAMP 11 Software Suite
University of Texas uses the Axon Patch-Clamp Systems to evaluate signaling mechanisms in the brain underlying memory and recall
Case studyAllegheny College uses our Axon patch-clamp instruments to investigate how amyloid beta peptide block ion channels in Alzheimer's disease
Case study