ImageXpress Micro XLS Widefield High-Content Analysis System

The ImageXpress® Widefield system is the ultimate combination of speed and flexibility in a turnkey solution to streamline the research and discovery workflow. It captures research-quality images with the widest range of objective lenses, enabling you to work at the resolution appropriate for your biology, including small organism, cellular or intracellular events. The system’s robust design precisely locates and identifies sub-cellular features, over multi-day time-lapse experiments when required.

Fewer images per well and shorter imaging time with a field of view that is 3x larger than industry standard.

A breadth of applications enabled by objectives ranging from 1x to 100x, 0.05 to 0.95 NA for air and 1.4 NA for oil, capturing a variety of cellular and intra-cellular events.

Accurate stage positioning for capturing high-resolution tiled or stitched images with fully-automated 100 nm resolution voice coil-driven stages, thereby minimizing X-Y stage jitter and ensuring repeatability of extended live-cell experiments.

Up to 5x faster read times while minimizing photobleaching with industry-leading autofocus using a dedicated 690 nm focus laser and ultra-fast sensors.

High-throughput screening captures > 10 million cells/hour in a low-resolution, whole-well, 3 color cell scoring application, or > 1 million cells/hour in a high resolution two-color assay.

Minimized user intervention using automated 5-position filter cube changer, facilitating multiplex assays with up to five filter sets and four objectives for a single experiment.

Modular design allowing for transmitted light, phase contrast, environmental control, fluidics, light source and external filter wheel selection.

Extensive sample compatibility from slides to plates (6- to 1536-well), thin to thick plate bottoms, glass to plastic, transwell, low profile- and low volume-plates.

Integrated automation, 24/7 with 3rd party robotic plate handling system, enabling you to schedule multiple runs.

Resources of ImageXpress Micro XLS Widefield High-Content Analysis System

Videos and Demos

Whole Organism Imaging

Whole Organism Imaging

High-Content Screening for Identifying miRNAs

High-Content Screening for Identifying miRNAs

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Calculate Decay Time Constant, and Perform Curve Fitting Using Axon pCLAMP Software

How to Combine Traces, Calculate Rise or Decay Time Constant, and Perform Curve Fitting Using Axon pCLAMP Software

Learn How to Change Filter Cubes inside the ImageXpress Micro System

Learn how to change filter cubes inside the ImageXpress Micro System

ImageXpress Micro XLS High Content Imaging Workflow

ImageXpress Micro XLS System high content imaging workflow

Create Customized Command Waveforms Using pCLAMP Software

How to Create Customized Command Waveforms Using the pCLAMP Software

Use of Sequencing Keys, User List, and Stimulus File with pCLAMP Software

The Use of Sequencing Keys, User List, and Stimulus File with pCLAMP Software

Synchronizing Electrophysiology and Imaging Solutions with pCLAMP and MetaMorph Software

Synchronizing Electrophysiology and Imaging Solution with Axon pCLAMP and MetaMorph Software

Membrane Test Between Sweeps in Clampex & Analysis of Synaptic Events with Clampfit Data Analysis

Online Statistics, Membrane Test Between Sweeps in Clampex and Analysis of Synaptic Events with the Clampfit™ Data Analysis

Preparing Assays for Genome-wide RNAi Screens

Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy

Use of Axoporator for Single-cell Electroporation for Transfection and Dye-labeling

Use of the Axoporator 800A for Single-cell Electroporation for Transfection and Dye-labeling

Using Axoclamp 900A for Two-Electrode Voltage-Clamp of Xenopus Oocytes Expressing Ion Channels

Using the Axoclamp 900A for Two-Electrode Voltage-Clamp of Xenopus Oocytes Expressing Ion Channels

Use of Filters in Data Acquisition and the Clampfit Application

Writing Long-Term Potentiation and Depression Protocols and the Use of Filters in Data Acquisition and the Clampfit Application

Resistance Compensated Series

Series Resistance Compensated or Not

Adult Stem Cells Engineered for Delivery of Therapeutic Factors

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Using Electrophysiological Studies to Accelerate Mechanistic in Reception and Transmission

Using Electrophysiological Studies to Accelerate Mechanistic Study in Reception and Transmission

Hardware Choices for Optogenetics Considerations for Synchronized Light Patterning

Update and Hardware Choices for Optogenetics Considerations for Synchronized Light Patterning

Effects of Amyloid-Beta Proteins on hSlo1.1, a BK Channel, in Xenopus Oocyte Model

Investigations of the Effects of Amyloid-Beta Proteins on hSlo1.1, a BK Channel, in a Xenopus Oocyte Model

Nanopores-Electronic Tools for Single-Molecule Biophysics and Bio-Nanotechnologies

Nanopores-Electronic Tools for Single-Molecule Biophysics and Bio-Nanotechnologies

High-throughput RNA Screening to Identify Host Factors

Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection

Chinese Version - Axon Amplifiers and pCLAMP Software Key Features Reviews

Axon Amplifiers and pCLAMP Software-key Features Reviews (Chinese version)

Using Clampfit in Basic Single Channel Analysis

Basic Single Channel Analysis Using Clampfit

Action Potential Analysis in Clampfit Module

Action Potential Analysis in Clampfit Module

A Walkthrough of Protocol Editor in pCLAMP Data Acquisition Module

A Walkthrough of the Protocol Editor in the pCLAMP Data Acquisition Module

A Walkthrough of Protocol Editor in pCLAMP (Chinese version)

A Walkthrough of Protocol Editor in pCLAMP (Chinese version)

3D Spheroid Assays Using High-Content Imaging

Setting up 3D Spheroid Assays Using High-Content Imaging

Customer Breakthrough

Gustave RoussyCancer
Gustave RoussyCancer

SUCCESS STORY

Gustave Roussy Cancer Center uses the ImageXpress Widefield Systems to assess mechanisms of cell stress and death in cancer treatment

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Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.