ImageXpress Micro XLS Widefield High-Content Analysis System
Illuminate, magnify, and demystify with widefield high-content imaging for fixed- or live-cell assays
ImageXpress Micro XLS Widefield High-Content Analysis System
The ImageXpress® Widefield system is the ultimate combination of speed and flexibility in a turnkey solution to streamline the research and discovery workflow. It captures research-quality images with the widest range of objective lenses, enabling you to work at the resolution appropriate for your biology, including small organism, cellular or intracellular events. The system’s robust design precisely locates and identifies sub-cellular features, over multi-day time-lapse experiments when required.
Fewer images per well and shorter imaging time with a field of view that is 3x larger than industry standard.
A breadth of applications enabled by objectives ranging from 1x to 100x, 0.05 to 0.95 NA for air and 1.4 NA for oil, capturing a variety of cellular and intra-cellular events.
Accurate stage positioning for capturing high-resolution tiled or stitched images with fully-automated 100 nm resolution voice coil-driven stages, thereby minimizing X-Y stage jitter and ensuring repeatability of extended live-cell experiments.
Up to 5x faster read times while minimizing photobleaching with industry-leading autofocus using a dedicated 690 nm focus laser and ultra-fast sensors.
High-throughput screening captures > 10 million cells/hour in a low-resolution, whole-well, 3 color cell scoring application, or > 1 million cells/hour in a high resolution two-color assay.
Minimized user intervention using automated 5-position filter cube changer, facilitating multiplex assays with up to five filter sets and four objectives for a single experiment.
Modular design allowing for transmitted light, phase contrast, environmental control, fluidics, light source and external filter wheel selection.
Extensive sample compatibility from slides to plates (6- to 1536-well), thin to thick plate bottoms, glass to plastic, transwell, low profile- and low volume-plates.
Integrated automation, 24/7 with 3rd party robotic plate handling system, enabling you to schedule multiple runs.
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eBook
The Axon™ Guide
The Axon Guide, a guide to electrophysiology and Biophysics laboratory techniques
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Product Brochure
ImageXpress Micro XLS Widefield High Content Screening System
Explore ImageXpress Micro Widefield High Content Screening System, a combination of speed & flexibility in a turnkey solution to streamline research & workflow.
Resources of ImageXpress Micro XLS Widefield High-Content Analysis System
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eBook
The Axon™ Guide
The Axon Guide, a guide to electrophysiology and Biophysics laboratory techniques
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Product Brochure
ImageXpress Micro XLS Widefield High Content Screening System
Explore ImageXpress Micro Widefield High Content Screening System, a combination of speed & flexibility in a turnkey solution to streamline research & workflow.
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Product Brochure
Cellular Imaging Solutions
Read more about Molecular Devices’ robust imaging systems, packaged with features such as intelligent analysis software to integrated data management & visual informatics.
Application Note
Homogeneous Antibody Binding Assay with High Content Imaging
The development of homogeneous antibody binding assays has increased the efficiency for high throughput, high content analysis of cell and bead assays. These no wash, fluorometric…
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Application Note
3D Imaging of Cancer Cell Spheroids
Many cancer cell lines will form spheroids if cultured on a favorable three dimensional (3D) matrix. These spheroids are believed to represent tumor physiology more closely than cells…
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Application Note
Live cell kinetics assay utilizing the ImageXpress Micro System
The ImageXpress® Micro Confocal/ XLS Widefield High-Content Imaging System from Molecular Devices includes optional Fluidics and Environmental Control modules, enabling single-channel…
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Application Note
Assaying cardiotoxicity with ImageXpress high-content screening systems
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the human physiological response in the…
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Application Note
Visualizing subcellular vesicles to quantitate autophagy in neuronal cells
Autophagy is an intracellular catabolic process that sequesters and degrades proteins and organelles that have either been recognized as faulty or are simply no longer needed by the…
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Application Note
High-throughput imaging assays using zebrafish, a model organism for human disease
Recently, zebrafish-based screening has gained favor as an alternative to mammalian screening due to cost, throughput and reduced ethical concerns. Zebrafish are a useful model for…
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Application Note
Apoptosis detection using EarlyTox Caspase-3/7-D NucView 488 Assay Kit on ImageXpress Micro systems
Apoptosis is an important mechanism signaling programmed death of cells in normal processes such as embryonic development, as well as in diseases including cancer and neurodegenerative…
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Application Note
High-content screening of neuronal toxicity using iPSC-derived human neurons
The nervous system is sensitive to the toxic effects of many chemical compounds, environmental agents and certain naturally occurring substances. Neurotoxicity can cause temporary or…
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Application Note
Intelligent time-lapse imaging to enhance live cell assay development
The ability to monitor responses in living cells over a specific period of time offers cell biologists several key advantages for assay development. For routine cellbased screening,…
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Application Note
Multiplexed high content hepatotoxicity assays using iPSC-derived hepatocytes
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy testing are crucial for improving drug…
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eBook
Advance Detection of Cytotoxicity
A wide range of solutions for predicting cytotoxicity earlier in your drug discovery process.
Scientific Poster
High-Throughput Assays for Characterizing Viability and Morphology of 3D Cancer Spheroid Cultures
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage…
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Scientific Poster
Phenotypic Assessment of Toxicity Using a Human Hepatocyte Co-Culture Model
Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving the drug development process and reducing drug attrition rates during clinic…
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Scientific Poster
Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety
Read more about cell based assays for measuring the impact of pharmacological compounds on the rate of beating cardiomyocytes with different assay platforms.
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Scientific Poster
Meeting Ultra‐High Throughput Imaging Challenges: Low Resolution, 1536 Well Plates, Homogeneous Assays
Explore solutions for scale-up challenges, such as imaging 1536‐well plates, obtaining useful imaging data from homogeneous assays, & shortening time to results.
Videos and Demos
Whole Organism Imaging
High-Content Screening for Identifying miRNAs
Identification of Selective Inhibitors of the STAT3 Signaling Pathway
How to Combine Traces, Calculate Rise or Decay Time Constant, and Perform Curve Fitting Using Axon pCLAMP Software
Learn how to change filter cubes inside the ImageXpress Micro System
ImageXpress Micro XLS System high content imaging workflow
How to Create Customized Command Waveforms Using the pCLAMP Software
The Use of Sequencing Keys, User List, and Stimulus File with pCLAMP Software
Synchronizing Electrophysiology and Imaging Solution with Axon pCLAMP and MetaMorph Software
Online Statistics, Membrane Test Between Sweeps in Clampex and Analysis of Synaptic Events with the Clampfit™ Data Analysis
Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy
Use of the Axoporator 800A for Single-cell Electroporation for Transfection and Dye-labeling
Using the Axoclamp 900A for Two-Electrode Voltage-Clamp of Xenopus Oocytes Expressing Ion Channels
Writing Long-Term Potentiation and Depression Protocols and the Use of Filters in Data Acquisition and the Clampfit Application
Series Resistance Compensated or Not
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Using Electrophysiological Studies to Accelerate Mechanistic Study in Reception and Transmission
Update and Hardware Choices for Optogenetics Considerations for Synchronized Light Patterning
Investigations of the Effects of Amyloid-Beta Proteins on hSlo1.1, a BK Channel, in a Xenopus Oocyte Model
Nanopores-Electronic Tools for Single-Molecule Biophysics and Bio-Nanotechnologies
Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection
Axon Amplifiers and pCLAMP Software-key Features Reviews (Chinese version)
Basic Single Channel Analysis Using Clampfit
Action Potential Analysis in Clampfit Module
A Walkthrough of the Protocol Editor in the pCLAMP Data Acquisition Module
A Walkthrough of Protocol Editor in pCLAMP (Chinese version)
Setting up 3D Spheroid Assays Using High-Content Imaging
Customer Breakthrough
SUCCESS STORY
Gustave Roussy Cancer Center uses the ImageXpress Widefield Systems to assess mechanisms of cell stress and death in cancer treatment
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