CellXpress.ai Automated Cell Culture System
The future of cell culture backed by machine learning and data-driven science.
Improve assay reliability and reproducibility by automating the entire cell culture workflow
The CellXpress.ai® Automated Cell Culture System is an AI‑powered automated platform designed to support routine and complex 2D and 3D cell culture workflows. The system integrates monitoring, feeding, scheduling, imaging, and machine learning‑driven decision logic to automate execution across cell culture workflows.
Pre‑configured, turnkey protocols enable efficient workflow setup, while 24/7 automated execution reduces hands‑on time and operational burden. A complete event log and digital microscopy records support traceability and reproducibility. Automated execution and standardized protocols enable consistent handling of complex cell culture workflows at scale while maintaining user‑defined control and oversight.
Automate your cell culture processes
Give your team back ~200 hours every week* by automating demanding feeding and passaging schedules.
Improve your screening workflows
Maximize your lab’s productivity and process over 100 plates in parallel** to grow and scale multiple stem cell, spheroid, or organoid lines.
Develop reliable, reproducible assays
A machine learning-assisted solution standardizes the development process to deliver consistent, unbiased, and biologically relevant results at scale.
* estimate based on 40-plate, iPSC culture with feeding, seeding, passaging, and monitoring.
** based on a study executing three overlapping 50, 41, and 10-plate experiments, across feeding, seeding, and monitoring steps.
Key capabilities
Scale up complex cell culture workflows.
Increase production of complex cell models, such as organoids, by up to 25X. External devices and optional rocking incubator ensure the system is flexible enough to handle complex protocols—such as those for brain organoids—and future-proof enough for protocols yet to come.
Evaluate & make decisions earlier.
Answer critical questions sooner easily identifying outliers at the well, plate, or experiment level to help detect variability sources. Save reagents by removing these plates or wells from downstream processing early in the drug discovery process.
Never miss a feeding event.
Give your cell culture technicians and scientists their weekends back. The CellXpress.ai system automates your cell culture, while image analysis workflows run 24/7 – even when your lab is closed.
Reduce human error.
Improve productivity and optimize hands-on time with image-based, deep-learning decision-making. Remove variability, maintain sterility, and increase confidence in success with automated cell handling.
Standardized protocols.
Turnkey protocols offer reliable and consistent automation that speed the development process. Real-time feedback alerts users to milestones or events and generates automated tasks to resolve them.
Track the complete cell journey over time.
A unified software environment makes it easy to develop traceable and reproducible cell cultures specific to your desired assay endpoint.
Turn data into decisions.
Solve complex image analysis problems utilizing advanced artificial intelligence (AI) to transform images into results. User-friendly workflows help you get answers faster from 2D, 3D, and time lapse experiments.
Complex biology simplified
An approachable automated solution, built by scientists for scientists to reduce hands-on work in real lab workflows.
The CellXpress.ai cell culture system was designed with the biologist’s point of view in mind. With the intuitive protocol wizard, users avoid complex scripting. Instead, you are able to build your workflows with an easy-to-use interface that follows the logical flow of the cell culture process.
The intuitive system dashboard gives you peace of mind to know that your culture run is operating as expected. A single software environment ensures that all the systems are operating at peak performance. No need to initialize individual instruments to ensure they are communicating with each other, simply walk up and use the system.
Error handling and reporting are integral to the system, so you can receive alerts should anything unexpected occur.
Machine learning-based decision-making allows users to distinguish between culture wells that are progressing as intended and those that aren’t. User alerts based on error or results-based conditions keep you advised of your cell culture status.
Relevant, reliable, and reproducible results
Access more biologically relevant models and ensure reproducibility—at scale
The CellXpress.ai cell culture system is a complete solution that standardizes the cell culture process—from maintenance, monitoring, and incubation, through imaging, analysis, and data processing—to deliver consistent, unbiased, and biologically-relevant results at scale.
- Unified software environment provides workflow repeatability through automation and applies imaging-guided AI decision-making to ensure cell culture feeding and passaging events happen at the right time.
- Powerful collaboration capabilities, leveraging built-in and custom protocols that can be easily executed, exported, and shared.
- System-ready robot integration support additional complex workflows—including centrifugation, confocal imaging, supernatant analysis, and calcium oscillation characterization.
The CellXpress.ai cell culture system is expandable and intended to support a variety of model system workflows in both 2D and 3D and in both matrix and matrix-free environments. Speak with one of our experts to discuss workflows that represent commonly used organoid culture protocols, including culture of 3D organoids in matrix domes or in low attachment plates, and iPSC culture protocols.
FAQs
What is the CellXpress.ai Automated Cell Culture System?
The CellXpress.ai Automated Cell Culture System is an automated platform designed to support routine cell culture workflows in research laboratories by integrating robotic handling with software‑driven and AI‑assisted processes.
What types of cell culture workflows does the system support?
The CellXpress.ai system is designed to support a range of cell culture workflows, including adherent and suspension 2D cultures, spheroids, iPSC_derived systems, and organoids such as brain and intestinal models. The workflows shown on this page are representative examples, and supported applications may vary depending on system configuration and research use.
Which parts of the workflow are automated versus user‑controlled?
Automation and user interaction within the CellXpress.ai system vary by workflow and configuration. Certain tasks can be automated, while users retain control over workflow design, setup, and oversight. The system can also generate alerts based on defined conditions or workflow milestones, enabling users to stay informed of culture status even when they are not physically present in the lab.
How is machine learning used in the CellXpress.ai system?
Machine learning is used to support specific system functions within the CellXpress.ai platform, such as assisting with monitoring or decision‑support processes, depending on configuration and documented use.
Is the workflow shown on this page the only workflow supported?
No. The workflow shown on this page is one example of many workflows supported by the CellXpress.ai system.
Is the CellXpress.ai system an end‑to‑end solution?
The CellXpress.ai system is designed to support end‑to‑end execution of supported workflows within a single platform, depending on configuration and research use.
How much time can I expect to save?
Time savings vary depending on workflow design, culture format, and system configuration. In general, automating feeding, passaging, and execution on a continuous schedule can significantly reduce hands‑on time and manual intervention compared to manual workflows. Representative time‑savings data across multiple model types are documented in the Giving Biologists Their Time Back eBook.
Latest Resources
Featured Applications
Customer Breakthrough
Applications of the CellXpress.ai Automated Cell Culture System
The CellXpress.ai® system is designed to enhance cell culture and assay protocols by addressing standardization, reproducibility, and scalability challenges. The system automates critical processes for various applications:
Specifications & Options of CellXpress.ai Automated Cell Culture System
CellXpress.ai cell culture system features and options
44 plate max – 2 rack capacity. Static racks
154 plate max – 7 rack capacity. Static racks
132 plate max static racks, 60 plate max rocking racks – 6-rack capacity
*CellXpress.ai cell culture system uses AutoQuant 2D Real Time Deconvolution