APPLICATION NOTE
Automated culture and functional analysis of compound responses in human iPSC-derived 3D tri-culture cardiac spheroids
Human iPSC-derived cardiac spheroids serve as a relevant model to evaluate drug effects and cardiotoxicity with automated culture and calcium imaging.
In this application note, we present an automated workflow for generating and analyzing human-induced pluripotent stem cell (iPSC)-derived 3D tri-culture cardiac spheroids as a model for cardiotoxicity assessment.
Using the CellXpress.ai™ Automated Cell Culture System and FLIPR® Penta Screening System, the process combines automated culture, functional calcium imaging, and high-content imaging to evaluate compound effects. This streamlined approach enables robust, reproducible analysis of drug-induced cardiac responses in vitro.
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Product family
Imaging
Product primary application
CellXpress.ai; FLIPR Penta High-Throughput Cellular Screening System; MetaXpress High-Content Image Acquisition and Analysis Software; FLIPR Calcium Assay Kits; ImageXpress Micro Confocal High-Content Imaging System
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701Rn00000ZeLHlIAN
Title
Automated culture and functional analysis of compound responses in human iPSC-derived 3D tri-culture cardiac spheroids
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