FLIPR Penta High-Throughput Cellular Screening System
High-throughput kinetic screening for toxicology and lead compound identification
An industry-renowned instrument for monitoring GPCRs and ion channels
Powered by a new, optional high-speed EMCCD camera and the new Peak Pro 2 software module, the new FLIPR® Penta High-Throughput Cellular Screening System allows you to measure and analyze peaks of human-derived induced pluripotent stem cells (hiPSCs), differentiated into cardiomyocytes and neurons, up to 100 times per second and quickly cherry pick events such as Early Afterdepolarization-like events (EAD-like events), fibrillation, and irregular beating.
Since its introduction, the system has developed a reputation for reliability and ease of use. The system can be configured based on library size, detection mode, screening format, assay, and target, making the transition from assay development to lead optimization a seamless process.
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Assess toxicity effects
The HS-EMCCD camera option allows for up to 100 measurements per second, providing detailed information about cardiomyocyte and/or neuronal oscillation. Combined with the ScreenWorks® Peak Pro 2 software analysis module, compound-induced pro-arrhythmic effects such as EAD-like events can be easily identified and flagged.
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Identify lead compounds
With seven LED sets, many filter options, and fluorescence or luminescence detection, the FLIPR system supports many assays, including calcium flux, potassium, and membrane potential.
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Configure to your throughput
The FLIPR Penta system can be configured to match user needs. From manual assays to automated solutions, to measuring 96-, 384-, or 1536-well samples at a time, to using wash or no-wash assay kits in adherent or suspension cell mode, the system can be upgraded as needs change in the future.
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FLIPR Penta High-Throughput Cellular Screening System
Features
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Complex event analysis
ScreenWorks Peak Pro 2 software analysis, powered by pCLAMP 11, gives you the unique ability to characterize calcium oscillation peak data in one software program. Compounds can be flagged that cause waveform irregularities that may indicate hazards for arrhythmia, seizures, or other toxicity effects quickly and without having to export data. Distinctly different calcium oscillations in neurons can also be characterized.
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Configurable optics
The FLIPR Penta system can be matched to user needs starting with a standard EMCCD camera, a more cost-effective solution that is perfect for GPCR and Membrane Potential assays, or with the new HS EMCCD that can capture up to 100 images per second and offers exceptional luminescence performance. The camera, LEDs, and filters can be configured at the time of purchase or later when assay needs change.
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User-changeable pipette modules
Pipette heads can be changed in minutes without the use of tools from 96, 384, or 1536 channels to accommodate assay throughput needs.
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Ease of use
ScreenWorks software seamlessly incorporates drag-and-drop protocols, intuitive buttons, and color-coded plate layout to simplify workflows. View signal traces, EC50 curves, and Z factors on-the-fly without having to export data to another software program.
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Validated solution
Purchasing a FLIPR system from Molecular Devices assures users that they are investing in a technology that can grow with them. Hardware, software, and assay kits have been validated on the system by an industry-renowned leader with over 30 years of experience.
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Custom automation options*
The drug discovery process has shared methods, yet each project is unique. The Advanced Workflow Engineering Solutions Team offers a variety of customized services from automated compound plate delivery to fully integrated workstations with automated incubation.
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Application Note
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Development of biologically relevant, predictive cell-based assays for compound screening and toxicity assessment is a major challenge in drug discovery.
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Application Note
Enhance your calcium screens with FLIPR Calcium 6 Assay Kits
Enhance your calcium screens with FLIPR Calcium 6 Assay Kits
FLIPR Calcium Assay Kits from Molecular Devices employ sensitive calcium indicators and proprietary masking dyes to enable researchers to conduct highly sensitive fluorescent screens of G…
Applications of FLIPR Penta High-Throughput Cellular Screening System
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Calcium Flux
The evaluation of calcium flux is a long accepted, tried and true measure of cellular activity. Calcium flux can be used as a measurement for a host of cellular processes including neurotransmitter release, GPCR activity, voltage or ligand gated ion channels, and cardiomyocyte beat patterns, among many others. The FLIPR Penta System is the drug discovery tool for evaluation of calcium flux in high and ultra-high throughput due to its ease of use, sensitivity and user configurability.
Calcium Flux
The evaluation of calcium flux is a long accepted, tried and true measure of cellular activity. Calcium flux can be used as a measurement for a host of cellular processes including neurotransmitter release, GPCR activity, voltage or ligand gated ion channels, and cardiomyocyte beat patterns, among many others. The FLIPR Penta System is the drug discovery tool for evaluation of calcium flux in high and ultra-high throughput due to its ease of use, sensitivity and user configurability.
Cardiomyocyte screening
Early prediction of drug-induced functional cardiotoxicity requires robust in vitro systems suitable for high-throughput screening. Readily-available iPSC-derived human cardiomyocytes may be used in conjunction with calcium-sensitive dyes, and beat rates are monitored as changes in intracellular calcium. These calcium peaks can be analyzed with our ScreenWorks PeakPro Software which provides the investigator a suite of powerful tools for quantification of cardiomyocyte activity.
Cardiomyocyte screening
Early prediction of drug-induced functional cardiotoxicity requires robust in vitro systems suitable for high-throughput screening. Readily-available iPSC-derived human cardiomyocytes may be used in conjunction with calcium-sensitive dyes, and beat rates are monitored as changes in intracellular calcium. These calcium peaks can be analyzed with our ScreenWorks PeakPro Software which provides the investigator a suite of powerful tools for quantification of cardiomyocyte activity.
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GPCR
Fluorescent dyes sensitive to changes in intracellular calcium have become increasingly popular in G protein-coupled receptor (GPCR) drug discovery. These dyes make GPCR screening assays highly sensitive, easy to perform, and low cost compared to other assays. Instruments capable of measuring fluorescent-based calcium indicators in high-throughput have become significantly more affordable making them obtainable even for academic groups.
GPCR
Fluorescent dyes sensitive to changes in intracellular calcium have become increasingly popular in G protein-coupled receptor (GPCR) drug discovery. These dyes make GPCR screening assays highly sensitive, easy to perform, and low cost compared to other assays. Instruments capable of measuring fluorescent-based calcium indicators in high-throughput have become significantly more affordable making them obtainable even for academic groups.
Membrane Potential
There are dozens of identified disorders caused by impaired ion channel function. Ion channels are important drug discovery targets because they are highly druggable and specific. The FLIPR® Membrane Potential Assay Kits provide a fast, simple and reliable fluorescence-based assay for detecting changes in voltage across the cell membrane mediated by ion channel to evaluate target or off-target effects based on the application.
Membrane Potential
There are dozens of identified disorders caused by impaired ion channel function. Ion channels are important drug discovery targets because they are highly druggable and specific. The FLIPR® Membrane Potential Assay Kits provide a fast, simple and reliable fluorescence-based assay for detecting changes in voltage across the cell membrane mediated by ion channel to evaluate target or off-target effects based on the application.
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Neuronal Assays
The FLIPR Penta System is an excellent tool for monitoring calcium flux related to neuronal activity. Newly developed commercially available iPSC neurons have made high-throughput neuronal screening a reality. These cells and assays are essential for monitoring a variety of factors including neural cell culture conditions, drug compound effects, and the effect of environmental neurotoxins. Neuronal activity and neurotransmitter release can be evaluated with fluorescence-based calcium indicator dyes combining fast, simple, and powerful assays with scalable throughput.
Neuronal Assays
The FLIPR Penta System is an excellent tool for monitoring calcium flux related to neuronal activity. Newly developed commercially available iPSC neurons have made high-throughput neuronal screening a reality. These cells and assays are essential for monitoring a variety of factors including neural cell culture conditions, drug compound effects, and the effect of environmental neurotoxins. Neuronal activity and neurotransmitter release can be evaluated with fluorescence-based calcium indicator dyes combining fast, simple, and powerful assays with scalable throughput.
Potassium Assays
Functional evaluation of potassium ion channels in a cell is of critical importance in the drug discovery process, particularly when it involves cardiac safety. The FLIPR® Potassium Assay Kit exploits the permeability of thallium ions (Tl+) through both voltage- and ligand-gated potassium (K+) channels. In this assay, a novel, highly-sensitive Tl+ indicator dye produces a bright fluorescent signal proportional to the number of potassium channels in the open state providing a functional indication of the potassium channel activities.
Potassium Assays
Functional evaluation of potassium ion channels in a cell is of critical importance in the drug discovery process, particularly when it involves cardiac safety. The FLIPR® Potassium Assay Kit exploits the permeability of thallium ions (Tl+) through both voltage- and ligand-gated potassium (K+) channels. In this assay, a novel, highly-sensitive Tl+ indicator dye produces a bright fluorescent signal proportional to the number of potassium channels in the open state providing a functional indication of the potassium channel activities.
Specifications & Options of FLIPR Penta High-Throughput Cellular Screening System
Resources of FLIPR Penta High-Throughput Cellular Screening System
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Application Note
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Development of biologically relevant, predictive cell-based assays for compound screening and toxicity assessment is a major challenge in drug discovery.
-
Application Note
Enhance your calcium screens with FLIPR Calcium 6 Assay Kits
Enhance your calcium screens with FLIPR Calcium 6 Assay Kits
FLIPR Calcium Assay Kits from Molecular Devices employ sensitive calcium indicators and proprietary masking dyes to enable researchers to conduct highly sensitive fluorescent screens…
eBook
Quantitate Neuron Potential
Quantitate Neuron Potential
Gain valuable insights into neurobiology, from evaluation of ion channels to analysis of 3D neuron organoids.
Brochure
FLIPR Penta High-Throughput Cellular Screening System
FLIPR Penta High-Throughput Cellular Screening System
Building on the success of the industry-leading FLIPR® platform for monitoring of GPCRs and ion channels, the FLIPR® High-Throughput Cellular Screening System offers a new high-speed ca…
Scientific Poster
Neurotoxicity profiling using 3D human iPSC-derived neural spheroids
Neurotoxicity profiling using 3D human iPSC-derived neural spheroids
Test compound effects and screen for neurotoxic chemicals using 3D neural spheroids.
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Application Note
Measure Calcium Oscillation in iCell Cardiomyocytes2 on the FLIPR Tetra System
Measure Calcium Oscillation in iCell Cardiomyocytes2 on the FLIPR Tetra System
Shorten growth timelines when screening compound effects on calcium transients in beating cardiomyocytes by using the iCell® Cardiomyocytes2 Kit (Cellular Dynamics International).…
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Application Note
Characterization of hERG channel blockers using the FLIPR Potassium Assay Kit on the FLIPR Tetra System
Characterization of hERG channel blockers using the FLIPR Potassium Assay Kit on the FLIPR Tetra System
Drug-induced inhibition of the human ether-à-go-go-related gene (hERG) ion channel has been related to the susceptibility of patients to potentially fatal ventricular tachyarrhythmia,…
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Application Note
Assessment of drug effects on cardiomyocyte physiology using human iPSC-derived cardiac spheroids
Assessment of drug effects on cardiomyocyte physiology using human iPSC-derived cardiac spheroids
Cell models are becoming more complex in order to better mimic in vivo microenvironments and provide greater predictivity for compound efficacy and toxicity. There is an increasing…
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Application Note
Comparison of Photina luminescent calcium mobilization assays on the FlexStation 3 reader and FLIPR Tetra System
Comparison of Photina luminescent calcium mobilization assays on the FlexStation 3 reader and FLIPR Tetra System
G protein-coupled receptors (GPCRs) represent one of the most important therapeutic targets in drug discovery research. GPCRs are membrane-localized proteins that play an important…
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Application Note
Introducing ScreenWorks® Peak Pro™ Software for FLIPR Tetra® Cellular Screening Systems
Introducing ScreenWorks® Peak Pro™ Software for FLIPR Tetra® Cellular Screening Systems
ScreenWorks Peak Pro Software: Visualize and analyze the temporal response curves associated with changes in intracellular calcium ion concentration. The new analysis features simplify…
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Application Note
Optimization of NaV1.5 channel assay with FLIPR Membrane Potential Assay Kits
Optimization of NaV1.5 channel assay with FLIPR Membrane Potential Assay Kits
FLIPR® Membrane Potential (FMP) Assay Kits provide a rapid and reliable fluorescence-based method to detect changes in membrane potential brought about by compounds that modulate or…
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Application Note
Measuring GPCR Activity Using the Tango GPCR Assay on the FLIPR Tetra Fluorimetric Imaging Plate Reader System
Measuring GPCR Activity Using the Tango GPCR Assay on the FLIPR Tetra Fluorimetric Imaging Plate Reader System
The FLIPR Tetra System has long been used for uHTS and HTS of fast-kinetic GPCR and ion channel assays. The limitations of current microplate readers with respect to format and…
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Application Note
Live cell Gi- and Gs -coupled GPCR second messenger signaling on the FLIPR Tetra System
Live cell Gi- and Gs -coupled GPCR second messenger signaling on the FLIPR Tetra System
In this application protocol we demonstrate the use of the modified luminescent firefly luciferase-based Promega GloSensor™ cAMP Assay on the FLIPR Tetra® High Throughput Cellular…
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Application Note
Homogeneous solution for GPCR assays with FLIPR Calcium 5 Assay Kit
Homogeneous solution for GPCR assays with FLIPR Calcium 5 Assay Kit
Combining a novel fluorophore and proven masking technology, the FLIPR Calcium 5 Assay Kit delivers reliable pharmacology, a larger signal window, and improved assay performance. With…
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Application Note
High throughput cardiotoxicity assays using stem cell-derived cardiomyocytes
High throughput cardiotoxicity assays using stem cell-derived cardiomyocytes
Eliminate cardiotoxic compounds and identify potential cardiac drug candidates earlier in the drug discovery process with the FLIPR Tetra System, together with ScreenWorks Peak Pro…
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Application Note
Comparison of intracellular calcium measurements with FLIPR Calcium Assay Kit
Comparison of intracellular calcium measurements with FLIPR Calcium Assay Kit
The FLIPR Tetra System delivers a screening platform to address real-time kinetic cell-based assays in 96-, 384- and 1536-well format. Regardless of the FLIPR Tetra System microplate…
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Application Note
Development of a Cav 1.3 channel assay using optogenetic methods on the FLIPR Tetra System
Development of a Cav 1.3 channel assay using optogenetic methods on the FLIPR Tetra System
In this study, we demonstrate the novel utility of optogenetic tools to control membrane potential in a reversible and precise fashion for screening state-dependent calcium channel…
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Application Note
Development of a cell-based potassium-chloride transporter assay using the FLIPR Potassium Assay Kit
Development of a cell-based potassium-chloride transporter assay using the FLIPR Potassium Assay Kit
The FLIPR Potassium Assay Kit can be used to measure the functional activity of the hKCC2 cation-chloride cotransporter using a homogeneous, no-wash protocol. The assay kit displays a…
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Application Note
Compound effects upon calcium transients in beating Axiogenesis Cor.4U human iPS cell-derived cardiomyocytes
Compound effects upon calcium transients in beating Axiogenesis Cor.4U human iPS cell-derived cardiomyocytes
The assessment of cardiotoxicity is important in the early stages of drug discovery to enable elimination of potentially toxic compounds from further development. This is critical to…
Data Sheet
FLIPR Tetra Instrument LED and Filter Combinations
FLIPR Tetra Instrument LED and Filter Combinations
This document provides the information about FLIPR Tetra Instrument LED and Filter Combinations. Explore this document for more detailed information.
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Data Sheet
FLIPR Tetra Aequorin Option
FLIPR Tetra Aequorin Option
FLIPR Tetra System provides industry-standard platform for real-time kinetic cellular assays which is user-configurable & easy to run and provides unmatched flexibility.
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eBook
Phenotypic Screening With iPSC-Derived Cardiomyocytes and Neurons
Phenotypic Screening With iPSC-Derived Cardiomyocytes and Neurons
This new eBook discusses early drug safety testing using HTS iPSC-derived cells with imaging. Download it now!
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Brochure
Pin Tool Liquid Handling for the FLIPR Tetra System
Pin Tool Liquid Handling for the FLIPR Tetra System
Explore this data sheet to learn about Pin tool liquid handling for FLIPR Tetra system which allows direct transfer of compounds that have been suspended in 100% DMSO or ethanol.
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Brochure
Mix and Match to Detect Your Favorite Assays on the FLIPR® System
Mix and Match to Detect Your Favorite Assays on the FLIPR® System
Explore PDF to learn about a broad range of optics for FLIPR Tetra System that enable application you require to support your research & screening.
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Scientific Poster
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Multi-parametric assessment of compound-induced pro-arrhythmic effects in human iPSC-derived cardiomyocytes
Development of biologically relevant and predictive cell-based assays for compound screening and toxicity assessment is a major challenge in drug discovery
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Scientific Poster
Evaluation of Cryopreserved Bacmam Transduced Aequorin Cells in 384-and 1536-Well Suspension Cell Assays Using the Aequorin Option for the FLIPRTETRA® System
Evaluation of Cryopreserved Bacmam Transduced Aequorin Cells in 384-and 1536-Well Suspension Cell Assays Using the Aequorin Option for the FLIPRTETRA® System
Explore PDF to learn about the FLIPR TETRA suspension cell system that provides an effective method to perform Aequorin assays over an extended period of time enabling robust HTS.
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Scientific Poster
Fluorescence-Based Neurotransmitter Transporter Uptake Assay in Primary Neuronal Cultures
Fluorescence-Based Neurotransmitter Transporter Uptake Assay in Primary Neuronal Cultures
Read this PDF to know how fluorescence-based assay kit is useful for the measurement of neurotransmitter transporter uptake activity in cell lines stably expressing the human DAT, NET,…
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Scientific Poster
Ratiometric Calcium Flux Measurements using Fura‐2 Ca2+ Indicator on the FLIPR® Tetra System
Ratiometric Calcium Flux Measurements using Fura‐2 Ca2+ Indicator on the FLIPR® Tetra System
Read this PDF to explore LED light sources with wavelengths at 340 nm and 380 nm which enable ratiometric Fura‐2 measurements on the FLIPR Tetra system.
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Scientific Poster
Calcium Release-Activated Channel (CRAC) Assays on the FLIPR® Tetra System: Evaluation of a Novel Fluorescent Calcium Reagent
Calcium Release-Activated Channel (CRAC) Assays on the FLIPR® Tetra System: Evaluation of a Novel Fluorescent Calcium Reagent
Get detailed information about Calcium release-activated calcium channels by exploring this PDF. Learn how CRAC channels are playing an important role in intracellular Ca2+ homeostasis.
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Scientific Poster
Cell Based Assays on the FLIPR® Tetra System: Comparison of a Novel FLIPR® Calcium Assay to other Fluorescence based Calcium Flux Assays
Cell Based Assays on the FLIPR® Tetra System: Comparison of a Novel FLIPR® Calcium Assay to other Fluorescence based Calcium Flux Assays
Cell based assays on FLIPR Tetra System to compare a novel FLIPRCcalcium 6 and 6-QF assay to other fluorescence-based calcium flux assays.
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Scientific Poster
Automated Functional Cellular Analyses of Human iPS-derived Cardiomyocytes
Automated Functional Cellular Analyses of Human iPS-derived Cardiomyocytes
This PDF explores live cell assays for measuring the impact of pharmacological compounds on rate & magnitude of beating cardiomyocytes using high content imaging & electrophysio…
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Scientific Poster
Live Cell Beating Assay Using Human iPSC-derived Cardiomyocytes for Evaluation of Drug Efficacy and Toxicity
Live Cell Beating Assay Using Human iPSC-derived Cardiomyocytes for Evaluation of Drug Efficacy and Toxicity
Learn about cell assays for measuring the impact of pharmacological compounds on rate & magnitude of beating cardiomyocytes using FLIPR Tetra & ImageXpress Micro Systems.
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Scientific Poster
A Novel Homogenous Potassium Ion Channel Assay for High-Throughput Screening
A Novel Homogenous Potassium Ion Channel Assay for High-Throughput Screening
Ion channels are a class of membrane proteins that mediate the movement of charged ions across the cell membrane. Potassium channels constitute the largest and most diverse group of ion…
Presentations
Functional and mechanistic neurotoxicity profiling using human iPSC-derived neural 3D cultures
Functional and mechanistic neurotoxicity profiling using human iPSC-derived neural 3D cultures
Expertise in human iPSC-derived neural and cardiac platforms; Focus on adapting platforms to HTS and producing assay-ready solutions to accelerate drug discovery; Neural platform: moc…
Videos and Demos
(On-demand webinar) FLIPR in drug discovery: Ion channel screening and cardiac safety testing
Optogenetics and the FLIPR: How to Use Light to Set up a Cav1.3 High-Throughput Screening Assay
Latest Advances in Calcium Flux Assays
Innovative Assays for the FLIPR Tetra System
Developing an in Vitro Tl+ Flux Assay for Potassium Channel Agonist Identification
Novel in Vitro Assay Tools for Cardiac Toxicity and Discovery
StemoniX microBrain 3D Assay Ready Plates for HTS
FLIPR Penta High-Throughput Cellular Screening System
| Product | Part Number |
| FLIPR Penta High-Throughput Cellular Screening System | FLIPR PENTA |
| Field Installations | |
| FLIPR Penta or Tetra Camera Conversion Kit, EMCCD to HSEMCCD | 5069580 |
| FLIPR Penta or Tetra Cell Suspension, Field Installation Kit | 0310-5339 |
| FLIPR Cycler (Previously TETRACycler) | 5074848 |
| Pipettor Heads | |
| FLIPR Pipettor Head Kit, 96 | 0200-6071 |
| FLIPR Pipettor Head Kit, 384 | 0200-6072 |
| FLIPR Pipettor Head Kit, 1536 | 0200-6073 |
| FLIPR Pin Tool Head Kit, 384 | 384 Pin Tool HD Kit |
| FLIPR Pin Tool Head Kit, 1536 | 1536 Pin Tool HD Kit |
| Pipetting Consumables | |
| FLIPR Penta or Tetra Pipette tips, black, non-sterile, 96-well 50 racks/case | 9000-0762 |
| FLIPR Penta or Tetra Pipette tips, clear, non-sterile, 96-well 50 racks/case | 9000-0761 |
| FLIPR Penta or Tetra Pipette tips, black, non-sterile, 384-well 50 racks/case | 9000-0764 |
| FLIPR Penta or Tetra Pipette tips, clear, non-sterile, 384-well 50 racks/case | 9000-0763 |
| FLIPR 1536 tip gasket, non-sterile, 40/case | 9000-0746 |
| FLIPR 1536 tip block | 0200-6112 |
| FLIPR Pin Tool head, 384 | 384 Pin Tool |
| FLIPR Pin Tool head, 1536 | 1536 Pin Tool |
| Optical Accessories | |
| LED Modules and Emission filter accessories are available for both versions of the FLIPR Penta or Tetra instrument for Calcium sensitive dyes, Membrane Potential dyes, Voltage Sensor dyes and other applications. Please follow this link to a .pdf of the wavelengths and ordering information | |
| Optional Cell Suspension System and Consumables | |
| FLIPR Suspension Reservoir | 0200-6222 |
| FLIPR 250 mL Spinner Flask Assembly | 0200-6223 |
| FLIPR 500 mL Spinner Flask Assembly | 0200-6224 |
| FLIPR 1 L Spinner Flask Assembly | 0200-6225 |
| FLIPR 2 L Spinner Flask Assembly | 0200-6226 |
| FLIPR 3 L Spinner Flask Assembly | 0200-6227 |
| FLIPR Potassium Assay Kit | |
| Evaluation Kit | R8330 |
| Explorer Kit | R8222 |
| Bulk Kit | R8223 |
| FLIPR Calcium 3 Assay Kit | |
| Explorer Kit | R8091 |
| Bulk Kit | R8090 |
| FLIPR Calcium 4 Assay Kit | |
| Explorer Kit | R8142 |
| Bulk Kit | R8141 |
| Express Kit | R8143 |
| FLIPR Calcium 5 Assay Kit | |
| Explorer Kit | R8185 |
| Bulk Kit | R8186 |
| Express Kit | R8187 |
| FLIPR Calcium 6 Assay Kit | |
| Evaluation Kit (1 Plate) | R8194 |
| Explorer Kit (10 Plates) | R8190 |
| Bulk Kit (100 Plates) | R8191 |
| Express Kit (100 Plates) | R8195 |
| FLIPR Membrane Potential Assay Kit | |
| Explorer Kit RED | R8126 |
| Bulk Kit RED | R8123 |
| Explorer Kit BLUE | R8042 |
| Bulk Kit BLUE | R8034 |
| FLIPR Calcium 6-QF Assay Kit | |
| Explorer Kit | R8192 |
| Bulk Kit | R8193 |
| Express Kit | R8196 |
1. Please contact your local Molecular Devices Sales Representative for details regarding this configure to-order item.
FLIPR Cycler and Robotic Integration
Optional Cell Suspension System and Consumables
An optional cell management system for the FLIPR Penta and Tetra Systems simplifies luminescent calcium mobilization assays and increases throughput by eliminating the need to plate cells and the need for separate compound plates during aequorin assays. Cells are held in spinner flask which maintains a uniform cell suspension and promotes assay robustness. During the assay, cells are pumped to the reservoir for pipetting and returned to the spinner flask. Adjustable stir speed, pump speeds and pipetting parameters simplify the optimization of cell handling for different cell lines. A variety of flask sizes are available to scale the volume for assay development through high throughput screening. Requires Part number 03010-5339 field installation of Cell Suspension system.
Related Products & Services of FLIPR Penta High-Throughput Cellular Screening System
Featured Applications
Calcium Flux
The evaluation of calcium flux is a long accepted, tried and true measure of cellular activity.…
Cardiomyocyte screening
Early prediction of drug-induced functional cardiotoxicity requires robust in vitro systems…
GPCR
Fluorescent dyes sensitive to changes in intracellular calcium have become increasingly popular in…
Membrane Potential
There are dozens of identified disorders caused by impaired ion channel function. Ion channels are…
Neuronal Assays
The FLIPR Penta System is an excellent tool for monitoring calcium flux related to neuronal…
Potassium Assays
Functional evaluation of potassium ion channels in a cell is of critical importance in the drug…
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