Lab automation for high-throughput plate-based assays
Fully-integrated, lab automation solution for protein and cell biology
Fully-integrated, lab automation solution for protein and cell biology
Plate-based assays form the cornerstone of many laboratory research programs. Whether you are performing biochemical assays such as ELISA, DNA/RNA quantitation, MTT cytotoxicity, or binding/affinity or cell-based assays such as CRISPR, viral titer, protein expression, bacterial growth, or cell signaling, Molecular Devices microplate readers have empowered life science researchers to advance discovery and produce high quality, reliable data.
As timelines become compressed and the amount of data required for IND submissions and publications increases, laboratories are increasingly pressed to do more with less. The introduction of automated workcells can help relieve this burden by allowing researchers to optimize their time in the lab and obtain data more efficiently. Additionally, automated data collection and data tracking reduce human error, assuring that the data is of a higher quality.
We work with you to build flexible, scalable, future-proof workcells that will meet the needs of your current workflow, as well as give you room to grow and expand in the future. We bring decades worth of consultative expertise to the table to help you design and implement workcells that incorporate industry-leading technology to achieve your goals. However, we recognize that your needs may change and evolve over time, therefore, we will continue to provide robust support and development to make sure your system continues to meet your needs.
Dip your toes into the water of laboratory automation with this entry-level system. Perform microplate-based assays on a large number of plates without having to manually feed them into your microplate reader. Load up the plates you need run and walk away while the robotic arm delivers them to the instruments to be read.
Ensure that your system can scale as your workflow expands by setting yourself up with a more sophisticated robotic arm. This system allows you to manually load assay plates into ambient hotels so that the robot arm can deliver them to the microplate reader when needed. A collaborative, four-axis robotic arm allows for the easy addition of instrumentation should your workflow require it in the future. (Instrument additions could include incubators, cellular imagers, single-cell sorters, centrifugation, and more) .
Eliminate the need to manually load plates onto the workcell and keep your plates in an environmentally regulated location with the addition of an automated incubator. Simply load your plates into the incubator, and the robot will deliver them to the plate reader at the designated time.
Enjoy increased flexibility and increased walkaway time with the addition of a liquid handler. An automated liquid handler allows the workcell to perform simple tasks, such as media changes or reagent additions, at the times you designate. This will enable you to conduct many assays with great precision and minimal manual intervention.
Harness the full potential of laboratory automation with maximum walkaway time. No further manual intervention is required once plates are loaded into the automated incubator. Plates will be moved automatically from the incubator into the workcell so that assays and treatments can be performed at designated times.
ELISA (Enzyme-linked Immunosorbent Assay) is one of the most popular quantitative methods to detect a target antigen such as toxin or foreign substance within a sample. The assay is easy to set up and the range of potential analytes is vast, but the assay procedure is time consuming and labor intensive.
Laboratory automation workflows can help with providing walkaway time, increasing throughput, effectiveness and efficiency of the assay procedure, and reproducibility.
Cell viability refers to the number of healthy cells in a population and can be evaluated using assays that measure enzyme activity, cell membrane integrity, ATP production, and other indicators. These methods can employ luminescent, fluorescent, or colorimetric readouts as indicators of general cell viability or even specific cellular pathways. Cytotoxicity and cell viability assays are often used to assess a drug or other treatment’s effect, and are valuable tools in the search for new therapeutics, as well as advancing our understanding of how normal cells function.
Cellular signaling allows cells to respond to their environment as well as to communicate with other cells. Proteins located on the cell surface can receive signals from the surroundings and transmit information into the cell via a series of protein interactions and biochemical reactions that comprise a signaling pathway. Multicellular organisms rely upon an extensive array of signaling pathways to coordinate the proper growth, regulation, and functioning of cells and tissues. If signaling between or within cells is dysregulated, inappropriate cellular responses may lead to cancer and other diseases.
Enzyme-linked immunosorbent assays (ELISAs) are used to measure the amount of a specific protein, using a microplate format, and results are most often detected via absorbance in the visible wavelength range. Chemiluminescent and fluorescent ELISA formats offer enhanced sensitivity for accurate quantitation of less abundant analytes.
Microbes, including bacteria, have been estimated to make up about 15 percent of the earth’s biomass, and microbes in the human body outnumber human cells by 10 to 1. These microorganisms provide great benefit to us and are also vital to many fields of research from medicine to alternative energy production. On the other hand, monitoring for microbes and the toxic substances they produce is necessary to ensure the safety of pharmaceutical products. Scientists whose research relies on mammalian cells must carefully monitor these cultures for unwanted microbial contaminants to ensure that their experimental results are reliable.
Nucleic acids are large biomolecules common to all known life forms. Deoxyribonucleic acid (DNA) consists of a double strand of pairs of nucleotides, while ribonucleic acid (RNA) is typically a single strand. In DNA, the nucleotides are adenine, cytosine, guanine, and thymine, while RNA contains uracil instead of thymine. DNA makes up the genetic material of all organisms, encoding the information cells need to synthesize proteins.
Protein detection, quantitation, and analysis are central to the investigation of a wide variety of biological processes. Measuring the concentration of protein is necessary to processes ranging from protein purification and labeling to sample preparation for electrophoresis. Protein can be quantitated directly via absorbance at 280 nm, or indirectly using colorimetric (BCA, Bradford, etc.) or fluorometric methods offering advantages such as greater sensitivity. To identify and measure a specific protein within a complex sample, for example, serum or cell lysate, an ELISA may be used.
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Cell viability refers to the number of healthy cells in a population and can be evaluated using…
Cellular signaling allows cells to respond to their environment as well as to communicate with…
Enzyme-linked immunosorbent assays (ELISAs) are used to measure the amount of a specific protein,…
Microbes, including bacteria, have been estimated to make up about 15 percent of the earth’s…
Nucleic acids are large biomolecules common to all known life forms. Deoxyribonucleic acid (DNA)…
Protein detection, quantitation, and analysis are central to the investigation of a wide variety of…
We’re here to help. Our highly qualified team of scientists and engineers can automate systems and entire workflows to meet specific needs of your assay, method, or protocol. Are you ready to explore an automated lab solution—saving time and resources while advancing scientific discovery?
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