Digital microscopy with automated brightfield, fluorescence, and Digital Confocal imaging

The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imager features a comprehensive portfolio of preconfigured protocols for cell-based assays to shorten the learning curve, so you can start running experiments quickly. With features such as Digital Confocal* 2D on-the-fly deconvolution, Live Preview, and multi-wavelength cell scoring, the ImageXpress Pico offers you the ability to advance your discoveries in a small, affordable imager.

  • Get started quickly

    Get started quickly

    With the icon-driven, user-friendly CellReporterXpress® Image Acquisition and Analysis Software, your entire lab can streamline their digital microscopy. Start capturing and analyzing images with minimal training.

  • Do more than cell counting

    Do more than cell counting

    Expand your assays with over 25 preconfigured templates optimized for many cell-based experiments including apoptosis, mitochondrial evaluation, 3D cell models, live cell/timelapse, multiwavelength cell scoring, and neurite tracing.

  • Automate imaging affordably

    Automate imaging affordably

    Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price allows researchers to afford the convenience of automated imaging and analysis on their lab bench. With options like Digital Confocal, environmental control and z-stack acquisition, the system can be ordered to fit your research.

ImageXpress Pico Automated Cell Imaging System – Feature Update

Features

  • Multiple imaging modes

    Multiple imaging modes

    The ImageXpress Pico system offers objectives ranging from 4x to 63x and can operate in colorimetric, brightfield, fluorescence, or Digital Confocal 2D on-the-fly deconvolution imaging modes.

  • Preconfigured analysis protocols

    Preconfigured analysis protocols

    Over 25 preconfigured analysis protocols ranging from simple cell counting to sophisticated neurite tracing analysis. With features like the click-to-find tool, analysis parameters can be optimized by simply clicking on a few cells that match specific criteria.

  • Plate-to-individual cell view

    Plate-to-individual cell view

    Data can be visualized at multiple levels from plate overview to individual cells. A wide variety of data visualization tools from the plate and cellular level empower users to learn as much as possible from their images and assays.

  • Z-stack acquisition

    Z-stack acquisition

    Generate sharper images for more accurate segmentation using z-stack acquisition. Acquire a series of images at different focal points to capture more detail than with a single slice. Users can include all slices or select which slices to include in the final projection.

  • Quickly and easily identify regions of interest

    Quickly and easily identify regions of interest

    Live Preview simplifies identification of regions of interest, letting users pan around the sample and interactively adjust focus with a virtual joystick, saving time and effort.

  • Environmental control

    Environmental control

    Multi-day, time lapse, and live cell assays can be run using the onboard environmental system with options for humidity, CO2, and O2 control. Optimized to prevent z-drift, the software also provides real-time monitoring of environmental state, ensuring optimal assay conditions.

Increase resolution with on-the-fly deconvolution

 

Significantly increase resolution and assay quality with Digital Confocal 2D on-the-fly deconvolution. The Digital Confocal Option restores light to its original point of origin, allowing you to decrease exposure time and improve statistical significance of your observations. Digital Confocal is seamlessly integrated into the ImageXpress Pico’s fluorescent image acquisition workflow allowing you to capture images with higher signal-to-noise data for more precise segmentation and analysis.

Request more information

 

 

*ImageXpress Pico Digital Confocal uses AutoQuant 2D Real Time Deconvolution
*NEW*

water immersion objectives

Applications of ImageXpress Pico Automated Cell Imaging System

  • Apoptosis Analysis

    Apoptosis Analysis

    Apoptosis is a process of programmed cell death important to a number of biological processes including embryonic development and normal tissue maintenance. Disruption in the regulation of apoptosis has been implicated in various diseases including cancer. Biochemical events lead to characteristic changes in cell morphology such as cell shrinkage, nuclear fragmentation, chromatin condensation, and mRNA decay, and ultimately cell death. Apoptosis can be initiated via the intrinsic or extrinsic pathways, and both pathways induce cell death by activating caspase enzymes

    Read More  

    Cell Counting

    Cell Proliferation

    Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division have a need to assess the number or density of cells in a well. Automated imaging can greatly speed up the cell counting process while reducing manual labor and human errors. Cells can be counted using a variety of methods, such as label-free cell counting under transmitted light or detection of nuclear dye with fluorescent imaging.

    Read More  

  • Digital Confocal

    Digital Confocal

    The ability of cells to adapt to their environment is mediated by highly controlled signaling pathways. In many cases, the initiation of these pathways by extracellular signals, such as hormones or cytokines, leads to the translocation of proteins from the cytoplasm to the nucleus. Once in the nucleus, these proteins can regulate the expression of target genes. Assays requiring precise identification of sub-cellular structures or molecules within different cellular compartments can benefit from the ability of image deconvolution to improve identification of the specific fluorescence signal against potentially high background caused by out-of-focus light. The ImageXpress Pico system with Digital Confocal 2D on-the-fly deconvolution is capable of measuring the translocation of proteins from the cytoplasm to the nucleus, like NF-κB translocation upon treatment with TNF-α. The enhancement in image resolution and maintenance of quantitative information from the image deconvolution leads to greater statistical significance in the analysis of nuclear translocation.

    Neurite Outgrowth / Neurite Tracing

    Neurite Outgrowth

    Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.

    Read More  

Specifications of ImageXpress Pico Automated Cell Imaging System

Resources of ImageXpress Pico Automated Cell Imaging System

Videos and Demos

Preview on Imagexpress Pico

How to easily image slides and regions of interest with Live Preview on the ImageXpress Pico

Standard Widefield Imaging

ImageXpress Pico Automated Cell Imaging System – Feature Update

Product Manager Interview

A Product Manager's Tour of the ImageXpress Pico

Environmental control settings in ImageXpress Pico

Configuring environmental control settings on the ImageXpress Pico

z-stack image acquisition using CellReporterXpress

How to perform a z-stack image acquisition using CellReporterXpress

ImageXpress Pico System

Cellular images to results in minutes with automated imaging

Setting up acquisition and analysis

Setting up acquisition and analysis on the ImageXpress Pico

Transmitted light cell scoring

Transmitted light cell scoring on the ImageXpress Pico

Reviewing Experiments on ImageXpress Pico

Reviewing completed experiments on the ImageXpress Pico

ImageXpress Pico Automated Cell Imaging System-Interactive Demo

ImageXpress Pico Automated Cell Imaging System

ImageXpress Pico Automated Cell Imaging System

Related Products & Services of ImageXpress Pico Automated Cell Imaging System

Featured Applications

Customer Breakthrough

MIMETAS uses ImageXpress Confocal
MIMETAS uses ImageXpress Confocal

SUCCESS STORY

MIMETAS uses the ImageXpress Pico and ImageXpress Micro Confocal systems to develop tissue models for their OrganoPlates®

A unique 3D organ-on-a-chip platform

Continue Reading

Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Maximize flexibility in application workflow and experimental design

Contact our specialist today to discuss how to implement a solution that works for you

Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Maximize flexibility in application workflow and experimental design

Contact our specialist today to discuss how to implement a solution that works for you