What is the current-clamp method?
The current-clamp method detects transmembrane voltage change resulting from ion channel activity. This technique allows the investigator to control the amount of current injected into the cell, thereby controlling the transmembrane potential.
In a current-clamp experiment, one applies a known current and measures the change in membrane potential (Vm) caused by the applied current. This type of experiment mimics the current produced by a synaptic input.
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