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Stem Cell Research

Stem cell research for the study of targets and pathways relevant to a disease process.

Calcium oscillations in iPSC derived cardiomyocytes
Calcium oscillations in iPSC derived cardiomyocytes

Stem cells provide unique "native" cell types that give researchers new opportunities to study targets and pathways relevant to disease processes. They offer a more reliable model to identify and confirm new drug targets and generate pharmacology and toxicology data earlier with strong translation to the clinical setting. Additionally, the application of stem cells in drug development creates a new path to personalized medicine, while at the same time reduces, or even potentially replaces animal testing. The ability to study human stem cell generated “primary tissue” is much closer to the human disease model vs. animal studies. Stem cells are also studied as direct methods for nerve regeneration for damaged nervous systems, heart disease or diabetes. See how the Sakaguchi Lab at Iowa State University is using neural stem cells to facilitate nerve regeneration. See customer story.

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Stem cell types

There are various types of stem cells available today. Most commonly available for drug discovery research are embryonic stem (ES) cells derived from early stage embryos, or induced pluripotent stem (iPS) cells generated from cells obtained from donors. The iPS cells can be differentiated into various cell types such as: neurons, cardiomyocytes, hematopoietic, hepatocytes, ocular or other types. Neurons are studied to understand disease such as Alzheimer's, where as cardiomyocytes or hepatocytes are used more often for early toxicology tests.

Here is a list of various resources we have available organized by the type of stem cell used.

Embryonic Stem Cells

Embryonic stem cells

Embryonic stem cells (ES) are derived from embryos and are considered pluripotent, meaning able to differentiate into any cell type. There are currently two main cell types, mouse ES cells and human ES cells.

Selecting Clones of Mouse Embryonic Stem Cells
Stem Cell-Derived Human Neurons in CNS Drug Discovery

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Neurons

Neurons
Stem cells differentiated into neurons are often used for drug discovery to study central nervous system (CNS) diseases such as Alzheimer's, schizophrenia, or anxiety. Neurons can also be used in toxicological assays to help predict drug safety and efficacy.


High-Content Assay for Morphological Characterization of Neuronal Development in 3D Matrix Using Human iPSC-Derived Neuronal Cultures
Toxicity Assays Using Induced Pluripotent Stem Cell-Derived Cells

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Cardiomyocytes

Cardiomyocytes

Stem cells differentiated into cardiomyocytes are used to screen for early potential toxicological effects of drugs, thus helping to avoid investment in development of drugs which would fail in clinical trials due to cardiac toxicity.


Multi-parameter in vitro assessment of compound effects on cardiomyocyte physiology using induced pluripotent stem cells
Compound effects upon calcium transients in beating Axiogenesis Cor.4U human

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Hematopoietic

Hematopoietic
Stem cells differentiated into hematopoietic progenitors (blood-forming stem cells) are important for both cell therapy and drug development. They can be used to treat patients with various blood disorders, such as leukemia or immune system disorders.

High-Throughput Multiplexed Assay for Analysis of Hematopoietic Stem Cells Differentiation and Hematopoietic Toxicity

Hepatocytes

Hepatocytes
Stem cells differentiated into hepatocytes, or liver cells, can be used to predict liver toxicity by drug candidates.  

Multiplexed high content hepatotoxicity assays using iPSC-derived hepatocytes

利用iPSC衍生的肝细胞 进行多参数高内涵肝细胞毒性检测

Other

Other
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies
Live cell imaging of co-cultured stem cells

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For the latest list of available resources, please visit our Library.


Stem cell application workflow

Stem cell application workflow
Selecting the right system for your stem cell applications can help you to simplify, expand, or automate your research.

Products to help you with your stem cell research

We continue to push our boundries to help you further your stem cell research. We have a number of instruments and assay kits to help you select the right cells, treat them for measurement, acquire the data, and analyze your results.

 


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Whether you’re looking for more information or are ready to set up your stem cell research, we are here to help! Click on the button to get more information, a demonstration, or pricing information.

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