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Intestinal Organoids

Intestinal Organoids

Intestinal organoids are 3D microtissue models that recapitulate structures in the intestinal lumen and on the surrounding intestinal epithelium.

Most intestinal organoids are derived from primary intestinal tissue cultured in Matrigel domes with growth factors. Under these conditions, the intestinal cells self-arrange to form a single epithelial layer. The epithelium contains the essential cell populations found in the adult intestinal epithelium and is arranged in a crypt-villus structure. It can simulate essential intestinal functions, such as nutrient absorption and mucus secretion.

The cell composition and arrangement of the epithelium make intestinal organoids useful for studying intestinal cell biology, regeneration, differentiation, as wells as diseases phenotypes including effects of specific mutations, microbiome, or inflammation process.

More great resources

Here describe high content imaging and image analysis methods that can be used for the characterization of organoid phenotypes.

 

 

Resources for Intestinal Organoids

Videos & Webinars

Application and Analysis of Organoid Systems

Capturing the complexity of 3D biology: Organoids for disease modelling and toxicity research

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