Intestinal Organoids
Intestinal organoids are 3D microtissue models that recapitulate structures in the intestinal lumen and on the surrounding intestinal epithelium.
Most intestinal organoids are derived from primary intestinal tissue cultured in Matrigel domes with growth factors. Under these conditions, the intestinal cells self-arrange to form a single epithelial layer. The epithelium contains the essential cell populations found in the adult intestinal epithelium and is arranged in a crypt-villus structure. It can simulate essential intestinal functions, such as nutrient absorption and mucus secretion.
The cell composition and arrangement of the epithelium make intestinal organoids useful for studying intestinal cell biology, regeneration, differentiation, as wells as diseases phenotypes including effects of specific mutations, microbiome, or inflammation process.
More great resources
Here describe high content imaging and image analysis methods that can be used for the characterization of organoid phenotypes.
Resources for Intestinal Organoids
Blog
Stem Cell Science and Regenerative Medicine – Technology and Methods Presented at ISSCR 2022
Stem Cell Science and Regenerative Medicine – Technology and Methods Presented at ISSCR 2022
It was another great year at ISSCR 2022! Leaders from across the globe came together to discuss new technologies, share insights, and explore the newest breakthroughs in stem cell…
Scientific Poster
Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology
Intestinal organoids for automated screening assays. High content imaging and analysis of organoid morphology
3D cell models representing various tissues were successfully used for studying complex biological effects, tissue architecture, and functionality. However, complexity of 3D models remains a…
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Blog
Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022
Engineering Next-gen Organoids with Automated Lab Workflows at #SLAS2022
SLAS2022, the Society for Lab Automation and Screening conference offered another exciting year for learning about innovative laboratory technologies. Whether you attended in-person…
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Scientific Poster
Automation of 3D organoid culture workflow with deep-learning based image analysis
Automation of 3D organoid culture workflow with deep-learning based image analysis
3D cell culture as a model system is increasingly popular because it recapitulates the in vivo microenvironment better than 2D cell cultures. Organoids have the capacity for stable different…
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Blog
History of Organoid Research: From Sponge Cells to Functional Organs
History of Organoid Research: From Sponge Cells to Functional Organs
Let's begin with a simple definition of an organoid which refers to a three-dimensional assembly that contains multiple cell types that are arranged with realistic histology, at…
Application Note
Organoids for disease modeling and in vitro drug screening
Organoids for disease modeling and in vitro drug screening
3D cell models representing various tissues were successfully used for studying complex biological effects, tissue architecture, and functionality. However, the complexity of 3D models…
Publications
Project Profile: Organoid Innovation Center
Project Profile: Organoid Innovation Center
Lab Manager speaks to Dan O’Connor, vice president, drug discovery, Molecular Devices, about the company’s Organoid Innovation Center in San Jose, CA. The center is 180 sq. ft., within a lar…
Customer Breakthrough
Bioneer use the ImageXpress Micro Confocal for high-throughput imaging of 3D disease models
Bioneer use the ImageXpress Micro Confocal for high-throughput imaging of 3D disease models
Revolutionizing early drug discovery for immuno-oncology and neurodegenerative disease modelling: High throughput imaging of 3D models of disease Bioneer A/S is a Danish research-based ser…
Videos & Webinars
Application and Analysis of Organoid Systems
Capturing the complexity of 3D biology: Organoids for disease modelling and toxicity research
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