Lab automation for high-throughput, high-content screening (HCS)
Fully-integrated, lab automation solution for 3D cell culturing and screening
Fully-integrated, lab automation solution for 3D cell culturing and screening
Our automated, high-content screening (HCS) workcell provides an end-to-end solution that helps standardize live 2D/3D cellular development process with cell culture, treatment, and incubation, through to imaging, analysis, and data processing, delivering consistent, unbiased, and biologically-relevant results at scale.
With intuitive scheduling software, researchers can control the 3D workflow remotely, tracking the cell journey from single cell to differentiated organoid along the way. Cell culture and incubation is streamlined with an automated incubator and collaborative robot that maintains culture consistency. Media exchange for culture maintenance is standardized and streamlined with automated liquid handling, minimizing manual intervention. 3D model development can be monitored over time with label-free imaging to assess assay readiness. Plus, with real-time feedback, scheduling of automated compound addition and treatment is standardized.
Check out our new Organoid Innovation Center at Molecular Devices where we showcase these cutting-edge technologies with novel 3D biology methods to address key challenges of scaling complex 3D biology. The collaborative space brings customers and researchers into the lab to test automated workflows for organoid culturing and screening, with guidance from in-house scientists.
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Beckman Coulter Biomek i7 automated liquid handler — Industry-leading liquid handler designed to optimize dependability and walk-away time in mid- to high-throughput labs with 45 deck positions, 0.5 - 5,000 µL pipetting volume range, and single or dual head options. |
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Bionex Solutions HiG4 automated centrifuge — Compact, temperature controlled centrifuge offers rapid acceleration up to 5000 x g, providing better pelletizing, cleaner supernatants, and faster filtration than lower speed centrifuges. |
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Biosero Green Button Go automation scheduling software — Proven software solution guides scientists through the automation experience, empowering them to control timing and scheduling of experiments to make better decisions in less time with more data. |
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LiCONiC Wave STX44 automated CO2 incubator — Complete solution for controlled environmental automated storage in laboratory automation designed with proprietary technology that delivers a robust system for frequent access and optimum environmental control using a variety of labware. |
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Precise Automation PreciseFlex 400 robot — Autosampler developed specifically for benchtop applications where price, ease-of-use, space requirements, and safety are critical, with a four axis configuration and a linear rail to service multiple stations within workcells of varying size. |
3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.
Brain organoids are 3D tissue models representing one or more regions of the brain. They can overcome the shortcomings of conventional post-mortem and animal brain models to produce clinically relevant results.
Cerebral organoids have great potential for understanding brain development and neuronal diseases. They can also be used for investigating genetic disorders and the effects of compounds. Nevertheless, capturing the uniqueness of the human brain requires functional assays and high-content imaging systems.
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
The drug discovery landscape is shifting, with more scientists centering cell line development, disease models, and high-throughput screening methods around physiologically-relevant 3D cell models. The reason for this is clear: Using cellular model systems in research that closely mimic patient disease states or human organs can bring life-saving therapeutics to market – faster.
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure rate can be traced to reliance on 2D cell cultures that don’t closely mimic complex human biology, often leading to inaccurate predictions of a drug’s potential and extended drug development timelines.
Intestinal organoids are 3D tissue models that recapitulate structures in the intestinal lumen and on the surrounding intestinal epithelium.
The cell composition and arrangement of the epithelium make intestinal organoids useful for studying intestinal cell biology, regeneration, differentiation, as wells as diseases phenotypes including effects of specific mutations, microbiome, or inflammation process.
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic the complex structure and functionality of human organs. Organoids typically consist of a co-culture of cells which demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.
Patient-derived tumor organoids or tumoroids are cultures of tumor cells that can be generated from individual patients. Tumoroids are highly valuable tools for cancer research, drug development, and personalized medicine.
Early detection and treatment are crucial in the survival rate of breast cancer patients. This necessitates the use of clinically relevant tumor models to understand the mechanism, analyze tumor biomarkers, and screen anticancer drugs. Breast cancer tumoroids provide the platform to study tumor physiology and response to targeted therapies.
Learn how to analyze breast cancer tumoroid growth and the efficacy of anticancer treatments with high-throughput screening and high-content imaging solutions:
Lung organoid cultures are 3D microtissue models recapitulating the morphological and functional characteristics of the airway, such as mucus secretion, ciliary beating, and regeneration. This biological relevance enables the study of repair/regeneration mechanisms in lung injury and phenotypic changes in pulmonary diseases. Lung organoids also can be used for toxicity assessment or drug testing.
Spheroids are multi-cellular 3D structures that mimic in vivo cell responses and interactions. They can be highly reproducible and to be scaled for high-content screening. Compared with adherent cells grown in 2D monolayers, 3D growth conditions are believed to more closely reflect the natural environment of cancer cells. Acquiring measurements from these larger structures involve acquiring images from different depths (z-planes) within the body of the spheroid and analyzing them in 3D, or collapsing the images into a single 2D stack before analysis.
Stem cells provide researchers with new opportunities to study targets and pathways that are more relevant to disease processes. They oer a more realistic model to identify and confirm new drug targets and generate pharmacology and toxicology data earlier, with stronger translation to the clinical setting. Additionally, the application of stem cells in drug development creates a new path to personalized medicine, while at the same time reducing, or even potentially replacing, animal testing.
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
Blog
We caught up with Laura Dranschak, Director of Commercial Operations & Custom Solutions, to catch up on all things SLAS 2023. See what all the buzz was about on the show floor,…
Blog
The drug discovery landscape is changing. Bringing a drug to market has historically been time-consuming and costly, with many candidates failing in the first phase of clinical trials…
Application Note
Many oncology drugs fail at the later stages of the drug development pipeline and in clinical trials, despite promising data for their efficacy in vitro. This high failure rate is…
Blog
Target discovery and drug development rely heavily on 2D cell and animal models to decipher efficacy and toxic effect of drug candidates. Yet, 90% of candidates fail to make it past…
News
SAN JOSE, Calif., and UTRECHT, Netherlands, Feb. 13, 2023 – Molecular Devices, LLC., a leading provider of high-performance life science solutions, and HUB Organoids (HUB), the pioneer…
Blog
Introduction – the problem. The average cost of bringing a new drug to the clinic is around $1 billion according to a study conducted by the London School of Economics in March 2020…
Blog
As we enter the era of sophisticated drug discovery with gene therapy and personalized medicine, we need to be prepared to study complex diseases, assess the therapeutic effect of…
Publications
More researchers are using gene editing to build disease models that better represent human tissues' complex biology, signaling a shift away from 2D cell culture or animal models to…
Publications
3DPrint.com, the leading source for actionable intelligence related to 3D printing technology and the larger AM industry, covers our collaboration…
Publications
Following our acquisition of Cellesce Ltd, Tanya Samazan from Instrument Business Outlook dove deep into conversation with Molecular Devices President Susan Murphy and Cellesce CEO V…
News
Turnkey platform integrates flexible robotic automation with high-content imaging of complex 3D cellular models, enabling high-volume organoid screening SAN JOSE, Calif., Jan. 4, 2023…
News
First-of-its-kind technology from Cellesce creates consistent patient-derived organoids for large scale drug screening Acquisition strengthens Molecular Devices’ position as a 3D…
Publications
Gone are the days of only measuring single parameters in cell-based experiments. Instead, researchers should widen their focus, namely with the help of innovations like the Cell Pain…
Publications
We recently partnered with HeartBeat.bio to automate and scale the production of cardioids — 3D cell models of the heart that can more accurately recapitulate human biology.
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Publications
In April 2021, we launched our Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process.…
Blog
SLAS Europe 2022, hosted numerous sessions packed with the latest research on emerging topics as well as sessions and panel discussions focused on how to build, and succeed, in a…
News
Larger site will be future home of the Organoid Innovation Center – Salzburg, a collaborative space for advancing automated cell line development, organoid development, and screening…
News
SAN JOSE, Calif., and VIENNA, Sept. 12, 2022 – Molecular Devices, LLC., a leading provider of high-performance life science solutions, and HeartBeat.bio AG, a biotech company…
Blog
It was another great year at ISSCR 2022! Leaders from across the globe came together to discuss new technologies, share insights, and explore the newest breakthroughs in stem cell…
Blog
3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. Their ability to self-organize and mimic…
Scientific Poster
Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functiona…
Blog
SLAS2022, the Society for Lab Automation and Screening conference offered another exciting year for learning about innovative laboratory technologies. Whether you attended in-person…
Blog
Imagine having the ability to mimic the human biological environment for disease modeling and drug screening and doing so in a micro-scale system. With the development of organ-on-a-…
Scientific Poster
3D cell culture as a model system is increasingly popular because it recapitulates the in vivo microenvironment better than 2D cell cultures. Organoids have the capacity for stable d…
Scientific Poster
Triple negative breast cancer is a clinically aggressive tumor subtype, with high rates of metastasis, recurrence, and drug resistance. Currently there are no clinically approved sma…
Blog
In life sciences, more is more. Obtaining a great body of data that is consistent and insightful to get a qualitative and quantitative overview of your model is critical. However,…
Application Note
Complex 3D biological models such as organoids and patient-derived spheroids are gaining popularity in many biomedical research areas because they more closely recapitulate the in vivo…
Blog
From customer feedback to workflow improvements The path to understanding complex biological processes and diseases is paved with a lot of challenges. As the desired level of…
Publications
"As the transition from 2D to 3D cell cultures, or organoids, as the gold standard for modeling basic biology and disease continues, these models are being utilized in ever m…
Blog
If you didn't get a chance to visit us at our poster sessions during ISSCR 2021, don’t fret. We've gathered all our sessions right here for you. The ISSCR Annual Meeting brought…
Application Note
We describe an automated integrated system that would allow automated monitoring, maintenance, and characterization of growth and differentiation of organoids and stem cells, as well…
Publications
Lab Manager speaks to Dan O’Connor, vice president, drug discovery, Molecular Devices, about the company’s Organoid Innovation Center in San Jose, CA. The center is 180 sq. ft., with…
Publications
Humans began culturing animal cells and tissues as early as the late 19th century, when Wilhelm Roux first showed that chick embryos could be cultured in saline solution for a few da…
Blog
There have been significant advancements in microscopy and camera technology, as well as advancements in technologies for labeling molecules of interest over the past decade. These…
Blog
Thanks to recent advances in imaging technologies, we are now able to observe and analyze complex cellular networks in three dimensions. Through 3D imaging, we can acquire and…
Publications
Molecular Devices, a provider of innovative life science technology, recently unveiled a brand new, first-of-its-kind Organoid Innovation Center. Situated at the company’s global hea…
Publications
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translational research. We describe here a novel…
Publications
In this guest editorial, explore how artificial intelligence is becoming a powerful tool for drug discovery
As part of the SelectScience Advances in Drug Discovery Special Fea…
Blog
Artificial intelligence (AI) is finding its way into many aspects of modern life, from autonomous vehicles to voice-powered personal assistants, and even the creation of art. But it…
Publications
Editor-in…
Scientific Poster
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translation research. Significant progress has b…
Scientific Poster
In recent years, researchers have transitioned from traditional 2D assays to more complex 3D cell models, as they are shown to recapitulate the in vivo environment and serve…
Blog
Have you ever heard the old adage, “A picture is worth a thousand words?” When it comes to Cell Painting, this saying is especially true. Cell Painting is a high-content,…
Publications
It has been a busy beginning of the year for Danaher’s Life Sciences segment. In January, the business reported 2020 revenues of $10.6 billion, represen…
Scientific Poster
In this study, we demonstrate improvement in assay sensitivity, precision, and speed of acquisition with a new configuration of the ImageXpress® Confocal HT.ai High-Content Imaging S…
Scientific Poster
Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functiona…
Scientific Poster
Organoid models have increasingly gained popularity in biologic research and screening to recapitulate complexity of real tissues. To model the in vivo human lungs, we have cultured…
Application Note
Here, we demonstrate improvement in assay sensitivity, quality, and speed of acquisition with the ImageXpress® Confocal HT.ai, our high-content imaging laser-based system.
Application Note
Here, we present a complete workflow for a cell painting assay that can be easily implemented using the ImageXpress Micro system and image analysis with machine learning capabilities
eBook
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
Blog
For over 40 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
Publications
Scientists take many roads to overcoming bottlenecks in workflows. For example, a workstation including a microplate reader can handle multiple steps, which improves efficiency and a…
Publications
The novel SARS-CoV-2 virus emerged in December 2019 and has few effective treatments. We applied a computational drug repositioning pipeline to SARS-CoV-2 differential gene expressio…
Blog
Accomplishing scientific breakthroughs can be a slow and arduous process. However, time is of the essence when dementia, cancer, cardiac disease, COVID-19, and more continue to…
Blog
Kayla Hill discusses the latest trends in cellular imaging We recently hosted a webinar with our Field Applications Scientist, Kayla Hill, PhD, who explored high-content analysis…
Publications
In drug discovery, time and monetary investments increase significantly the further candidates advance through the preclinical phase of testing, analysis and evaluation. By excluding…
Publications
Sebastian Peck is a senior product manager for cellular imaging at Molecular Devices, one of the world's leading providers of high-performance bioanalytical measurement systems, soft…
Publications
Microfluidic flowchip technology combined with three-dimensional (3D) imaging is a powerful duo poised to change the future of drug discovery and development. The integration of comb…
Publications
Neurological disorders impact up to a billion people around the world and appear to be on the rise [1]. In fact, those affecting the central and peripheral nervous systems – includin…
Application Note
Angiogenesis is the physiological process of formation and remodeling of new blood vessels and capillaries from pre-existing blood vessels. This can be achieved through endothelial…
Publications
In an effort to better understand the cellular responses to COVID-19, the digital biology company Recursion has publicly released the world’s largest imaging dataset portraying thera…
Publications
With each passing day, continuous advancements are being made in the studies that cutting-edge instruments can perform and in the complexity of the biological samples that are being…
Publications
OUR ABILITY to image cells has come a long way since the pioneering days of Galileo Galilei and Antonie van Leeuwenhoek. The multiple imaging techniques available today range from si…
Publications
Jayne Hesley is a Senior Applications Scientist for Cellular Imaging at Molecular Devices, LLC. She has over 10 years’ experience developing cell-based applications using ImageXpress…
Publications
Depending on your application and exactly what you are researching, there are multiple imaging techniques available, ranging from confocal microscopy to electron microscopy and more…
Scientific Poster
The purpose of these studies was to determine if water immersion objectives, used to improve image quality in complex biological assays, could be used in a high-throughput environmen…
Publications
The Society for Laboratory Automation and Screening (SLAS) held their annual conference January 25–29 in San Diego, California. The show hosts presentations, short courses and an exh…
Publications
Molecular Devices partners with MIMETAS to scale up organoid screening—helping researchers go from 2D to 3D phenotypic relevant organoid screening. At SLAS 2020, they featured the Im…
Publications
The biotechnological start-up is focused on in vitro preclinical research and development, with a specialization in automated cellular imaging: high-content analysis (HCA) and high-c…
Publications
The biotechnological start-up is focused on in vitro preclinical research and development with a specialization in cellular imaging: high-content analysis (HCA) and high-content scre…
Publications
Ever since the discovery that tumors undergo angiogenesis in order to grow and survive, researchers have sought to better understand the detailed mechanism of new blood vessel format…
Publications
Angiogenesis is an important field of research and a focus for cancer therapeutics. In this interview, Dr. Bas Trietsch, CTO, MIMETAS, introduces a new solution for the study of angi…
Publications
Recent years have seen an increasing demand for drug discovery and development processes to use more predictive, higher complexity, physiologically-relevant three-dimensional (3D) ce…
Publications
Developments in informatics solutions and high-content imaging instruments, increased focus on cell-based research, and rising government support of research and development for drug…
eBook
A streamlined workflow for cell counting and phenotypic characterization is critical to many experiments. Our SpectraMax® i3x microplate reader with MiniMax™ cytometer provides you w…
Application Note
Establishment of physiologically-relevant in vitro models is crucial to further understanding of the mechanisms of neurological diseases as well as targeted drug development. While…
The search for answers: Using lab automation with patient-derived tumoroids to find more relevant therapies for clinically aggressive cancers
Automating culture and high-content imaging of 3D organoids for in vitro assessment of compound effects
Tips to automating molecular cloning and strain engineering applications
Organoid Innovation Center Walkthrough
Disease modeling in the 21st century: Automated organoid assays with 3D imaging
High-throughput, organoid-derived organ-on-a-chip systems for drug discovery and disease modelling
Transitioning high-content assays to 3D: Scientific opportunities and imaging challenges
Getting started with imaging 3D cell models – all you need to know
Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging
Physiologically-Relevant Tissue Models Using a High-Throughput Organ-on-a-Chip Platform
Increase efficiency and throughput with cloud-based advanced analytics
Provides robust, quantitative results from complex biological images and datasets
Transform your incredible images into captivating results
3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including…
Brain organoids are 3D tissue models representing one or more regions of the brain. They can…
Cancer researchers need tools that enable them to more easily study the complex and often poorly…
The drug discovery landscape is shifting, with more scientists centering cell line development,…
For every drug that makes it to the finish line, another nine don’t succeed. This alarming failure…
Intestinal organoids are 3D tissue models that recapitulate structures in the intestinal lumen and…
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic…
Patient-derived tumor organoids or tumoroids are cultures of tumor cells that can be generated from…
Lung organoid cultures are 3D microtissue models recapitulating the morphological and functional…
Spheroids are multi-cellular 3D structures that mimic in vivo cell responses and interactions. They…
Stem cells provide researchers with new opportunities to study targets and pathways that are more…
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It…
We’re here to help. Our highly qualified team of scientists and engineers can automate systems and entire workflows to meet specific needs of your assay, method, or protocol. Are you ready to explore an automated lab solution—saving time and resources while advancing scientific discovery?
![3D Biology: The paradigm shift in next-generation drug discovery [Interactive infographic]](/sites/default/files/2023-04/3d-biology-paradigm-next-gen-drug-discovery.jpg)
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