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University of Sheffield uses ImageXpress Widefield system to run genome-wide screens in Drosophila

COMPANY/UNIVERSITY

University of Sheffield, Sheffield RNAi Screening Facility

TEAM MEMBERS

Stephen Brown, PhD, Sheffield RNAi Screening Facilities Manager

PRODUCTS USED

ImageXpress Micro XLS Widefield High-Content Analysis System

The Challenge

Funded by Yorkshire Cancer Research and the UK cancer charity, the Sheffield RNAi Screening Facility was established as the first Drosophila RNAi screening center in the UK. The facility provides a high-throughput RNAi screening service to researchers studying genes involved in many diseases and pathways. The group recently published results of a whole-genome RNAi screen, where high-content microscopy was used to characterize genes regulating the mitophagy pathway that is linked to Parkinson’s disease.
Stephen Brown, PhD, Sheffield RNAi Screening Facilities Manager

The Solution

This screening workflow using the ImageXpress® Micro System shortens time to result significantly from 6-12 weeks down to 10-14 days. Furthermore, reliability and robustness of the system ensure consistent uptime and quality data from a walk-away operation.

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ImageXpress Micro XLS Widefield High-Content Analysis System

ImageXpress Micro XLS Widefield High-Content Analysis System

Details

Products Used

The ImageXpress Micro XLS High-Content Analysis System has been replaced by the ImageXpress Micro 4 High-Content Analysis System, which represents the culmination of four generations of imaging expertise. The latest agile design allows you to boost your research with this faster-than-ever system, while providing the option to upgrade to confocal in the future to align with your research needs.

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References

https://www.pnas.org/content/111/23/8494

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