Funded by Yorkshire Cancer Research and the UK cancer charity, the Sheffield RNAi Screening Facility was established as the first Drosophila RNAi screening center in the UK. The facility provides a high-throughput RNAi screening service to researchers studying genes involved in many diseases and pathways. The group recently published results of a whole-genome RNAi screen, where high-content microscopy was used to characterize genes regulating the mitophagy pathway that is linked to Parkinson’s disease.