The Axon™ pCLAMP™ Software Suite is the most widely-used patch-clamp electrophysiology data acquisition and analysis program for control and recording of voltage-clamp, current-clamp, and patch-clamp experiments.
The software suite consists of:
Clampex 11 Software—flexible data acquisition
Clampex 11 is built on the previous version 10, which already has a powerful built-in feature set. Enhancements include:
Clampfit 11 Software—smart data analysis
Clampfit 11 Software offers a comprehensive palette of tools for data analysis. Highlights include:
Clampfit Advanced Analysis Module—sophisticated data analysis
This module is a set of tools that expand the capabilities of Clampfit to combine powerful analyses with ease-of-use. Highlights include:
The following are also supported:
*Supports all previous versions in a model line.
**We only support Professional, Enterprise, and Ultimate editions but not Home edition.
There are 3 types of pCLAMP licenses available:
Enhanced Protocol Editor
- 50 Epochs
- Increased sweep duration
Improved Membrane Test
- Display multiple channels simultaneously
- Individual command control
Enhanced Gap-free recording
- Pre-program voltage level
- Pre-program holding duration
- Pre-program digital output
Basic ion channel research
Ion channels are pore proteins that are involved in a large variety of physiological processes. Basic research in the ion channel field furthers the understanding of ion channel function as well as their roles within cellular pathways and processes. Single-channel research helps with elucidating the mechanisms underlying ion channel function on a single-molecule level. Whole-cell and perforated patch clamp recordings are typically used to investigate the action of modulators on entire populations of ion channels in the membrane of a cell. Learn more.
Cell pathway analysis
Ion channels are involved in many cell pathways and understanding the function of ion channels in response to changes in membrane potential or the presence or absence of other molecules is important in order to understand exactly how ion channels participate in normal and abnormal biological processes such as cell differentiation and migration, disease states, neuronal communications, etc.
Ion channels play a role in many diseases including hypertension, cardiac arrhythmias, gastrointestinal, immune and neuromuscular disorders, pathological pain, and cancer. By understanding the exact role that ion channels play in a particular disease, researchers might be able to find a way to affect the ion channel in such a way as to alter the course of the disease.
A critical part of drug discovery involves safety assessments, such as hERG testing, in order to eliminate any compounds with potential safety concerns. Conventional patch clamp has played an important role in collecting evidence for the absence of side effects before submission of a drug candidate to regulatory authorities. Even if automated electrophysiology has shifted safety testing to earlier stages in the drug discovery process, follow-up with conventional patch clamp is an essential step in the workflow.