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Fluorescence imaging platform within reach of every lab

The ImageXpress® Nano Automated Imaging System features a long life, solid state, light engine, and optics to reliably deliver the right assay sensitivity. Capture fine details of a variety of cellular and subcellular assays with this powerful and flexible fluorescent microscopy solution. The system includes MetaXpress® High-Content Image Acquisition and Analysis Software with tools for 2D and 3D imaging and time lapse analysis, as well as a range of needs from ease-of-use through to proprietary assay design.

  • Image label-free

    Image label-free

    Brightfield imaging allows for rapid acquisition without the use of harmful fluorescent agents.

  • Streamline image analysis

    Streamline image analysis

    The modular toolbox in the MetaXpress® software allows for the quick setup of hundreds of routine assays. Choose from our optional selection of turnkey application modules for greater convenience.

  • Capture a diverse range of samples

    Capture a diverse range of samples

    With 2x to 60x magnification, the system offers the flexibility to image whole-well (C. elegans, zebrafish), as well as sub-cellular details (vesicles, organelles).

ImageXpress Nano High Content

ImageXpress Nano High-Content Imaging System Virtual Tour

Features

  • Large field of view

    An entire well of a 384-well plate can be captured in a single image at 4x magnification for faster throughput.

  • Automated Stages

    Fully automated X, Y, and Z stages with resolution better than 25 nm.

  • Wide range of filters and objectives

    The system can be configured with different filters or objectives (2-60x) to meet research needs.

  • Five fluorescent channels

    The system can have up to 5 fluorescent filters installed at one time. The software allows up to 7 channels to be acquired at one time which enables multi-channel fluorescent and transmitted light imaging in one experiment.

  • High-speed autofocus

    Laser autofocus enables quick, consistent focusing across plates, slides and uneven surfaces.

  • Environmental control option

    Environmental control option

    Multi-day, time lapse and live cell assays can be run using the onboard environmental system with options for temprature, humidity, and CO2 control.

Introducing the MetaXpress 3D Analysis Toolkit

MetaXpress high-content image aquisition and analysis software

 

  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

Applications of ImageXpress Nano Automated Imaging System

  • 3D Cell Models

    3d Cell Models

    3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.

    Read More 

    Cancer Research

    Cancer Research

    Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.

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  • Cardiomyocytes

    Cardiomyocytes

    Stem cells differentiated into cardiomyocytes are used to screen early for potential toxicological effects of drugs, thus helping to avoid investment in development of drugs which will fail in clinical trials due to cardiac toxicity.

    Cell Counting

    Cell Counting

    Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division rely on the assessment of the number or density of cells in a well.

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  • Cell Migration Assays

    Cell migration assays

    The movement or migration of cells is often measured in vitro to elucidate the mechanisms of various physiological activities such as wound healing or cancer cell metastasis. Cell migration assays may be conducted in a controlled environment using live cell timelapse imaging.

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    COVID-19 and Infectious Disease Research

    COVID-19 and Infectious Disease Research

    Here we've addressed common applications in infectious disease research including cell line development, binding affinity, viral neutralization, viral titer and more with a focused effort on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19 including vaccines, therapeutics and diagnostics.

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  • Live Cell Imaging

    Live Cell Imaging

    Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.

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    Neurite Outgrowth / Neurite Tracing

    Neurite Outgrowth

    Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.

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  • Stem Cell Research

    Stem Cell Research

    Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.

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    Toxicity Screening

    Toxicity Screening

    Screening for off-target or toxic effects is very important during the development of new drugs and for the extension of the therapeutic potential of existing molecules. ImageXpress systems are fully integrated hardware and software platforms for automated acquisition and analysis of images for high-throughput cell-based cytotoxicity testing. Configured with optional environmental control, living cell responses or kinetic reactions can be monitored in real time for several days.

    Read Application Note 

Specifications & Options of ImageXpress Nano Automated Imaging System

Resources of ImageXpress Nano Automated Imaging System

Presentations
Videos & Webinars
Antigen / Immunogen Discovery and Optimization

Immunology and Vaccine Development Workflow

Hybridoma Workflow

Hybridoma Workflow

Accelerate your Screening with Automated Imaging

Accelerate your screening with high-content and automated imaging

Microplate based Detection

Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening

ImageXpress Nano High Content

ImageXpress Nano High-Content Imaging System Virtual Tour

Magnetic 3D

Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow

Labtube Meets SLAS

LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch

Plate annotation and curve fitting in MetaXpress

Plate annotation and curve fitting in MetaXpress

Plate acquisition on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress

Review images on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress

Image analysis on ImageXpress Micro Confocal using MetaXpress

Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress

Developing High Throughput Organ on a Chip Tissue

Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging

  • Citation
    Dated: Jan 12, 2021
    Publication Name: Molecular Devices | Sunnyvale, CA

    Detection of autophagy using automated imaging

    Autophagy is a highly regulated process of degrading and recycling damaged proteins and organelles in response to cellular stress.1, 2 It is mediated by a unique vesicle called the autophagosome, which is assembled by the formation of a double membrane around the cellular component marked for destruction.1 The autophagosome vesicle then fuses with… View more

    Autophagy is a highly regulated process of degrading and recycling damaged proteins and organelles in response to cellular stress.1, 2 It is mediated by a unique vesicle called the autophagosome, which is assembled by the formation of a double membrane around the cellular component marked for destruction.1 The autophagosome vesicle then fuses with the lysosome to deliver its contents for degradation by lysosomal hydrolases.

    Contributors: Oksana Sirenko  
    Go to article

  • Citation
    Dated: Sep 25, 2018
    Publication Name: Platelets

    Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction

    The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is… View more

    The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is ambiguous as previous reports have been contradictory. It is therefore unclear if MEK inhibitors might be causing platelet dysfunction and contributing to increased hemorrhage. In the present study we performed pharmacological characterisation of cobimetinib and trametinib in vitro to investigate potential for MEK inhibitors to cause platelet dysfunction.

    Contributors: Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy & Jonathan M. Gibbins  
    Go to article

  • Citation
    Dated: Oct 27, 2017
    Publication Name: Cambridge University Press

    Park NX12 Microscope for NanoScale Imaging

    The Park NX12 is an inverted optical microscope based SPM platform for SICM, SECM, and SECCM, in addition to atomic force microscopy for research on a broad range of materials from organic to inorganic, transparent to opaque, and soft to hard. Park NX12 is suited for advanced research on materials such as membranes, organic devices and electronics… View more

    The Park NX12 is an inverted optical microscope based SPM platform for SICM, SECM, and SECCM, in addition to atomic force microscopy for research on a broad range of materials from organic to inorganic, transparent to opaque, and soft to hard. Park NX12 is suited for advanced research on materials such as membranes, organic devices and electronics, and biological and pathological samples in both air and liquid, plus a solution and platform for pipette-based SPM techniques.

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