ImageXpress Nano Automated Imaging System
High-content imaging system for your everyday biological needs
ImageXpress Nano Automated Imaging System
Fluorescence imaging platform within reach of every lab
The ImageXpress® Nano Automated Imaging System features a long life, solid state, light engine, and optics to reliably deliver the right assay sensitivity. Capture fine details of a variety of cellular and subcellular assays with this powerful and flexible fluorescent microscopy solution. The system includes MetaXpress® High-Content Image Acquisition and Analysis Software with tools for 2D and 3D imaging and time lapse analysis, as well as a range of needs from ease-of-use through to proprietary assay design.
Features
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Large field of view
An entire well of a 384-well plate can be captured in a single image at 4x magnification for faster throughput.
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Automated Stages
Fully automated X, Y, and Z stages with resolution better than 25 nm.
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Wide range of filters and objectives
The system can be configured with different filters or objectives (2-60x) to meet research needs.
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Five fluorescent channels
The system can have up to 5 fluorescent filters installed at one time. The software allows up to 7 channels to be acquired at one time which enables multi-channel fluorescent and transmitted light imaging in one experiment.
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High-speed autofocus
Laser autofocus enables quick, consistent focusing across plates, slides and uneven surfaces.
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Environmental control option
Multi-day, time lapse and live cell assays can be run using the onboard environmental system with options for temprature, humidity, and CO2 control.
MetaXpress high-content image aquisition and analysis software
- Meet high throughput requirements with a scalable, streamlined workflow
- Adapt your analysis tools to tackle your toughest problems, including 3D analysis
- Schedule automatic data transfer between third-party hardware sources and secure database
- Set up hundreds of routinely used HCS assays using MetaXpress software modules
![3D organoids and automation of complex cell assays [Podcast]](/sites/default/files/2023-01/3d-organoids-and-automation-of-complex-cell-assays.jpg)
Applications of ImageXpress Nano Automated Imaging System
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3D Cell Models
3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.
Cancer Research
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
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Cardiomyocytes
Stem cells differentiated into cardiomyocytes are used to screen early for potential toxicological effects of drugs, thus helping to avoid investment in development of drugs which will fail in clinical trials due to cardiac toxicity.
Cell Counting
Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division rely on the assessment of the number or density of cells in a well.
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Cell Migration Assays
The movement or migration of cells is often measured in vitro to elucidate the mechanisms of various physiological activities such as wound healing or cancer cell metastasis. Cell migration assays may be conducted in a controlled environment using live cell timelapse imaging.
COVID-19 and Infectious Disease Research
Here we've addressed common applications in infectious disease research including cell line development, binding affinity, viral neutralization, viral titer and more with a focused effort on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19 including vaccines, therapeutics and diagnostics.
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Live Cell Imaging
Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.
Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
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Stem Cell Research
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.
Toxicology
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
Resources of ImageXpress Nano Automated Imaging System
Blog
How 3D Cell Models Will Shape the Future of Drug Discovery
How 3D Cell Models Will Shape the Future of Drug Discovery
Target discovery and drug development rely heavily on 2D cell and animal models to decipher efficacy and toxic effect of drug candidates. Yet, 90% of candidates fail to make it past…
News
Molecular Devices inks deal with HUB Organoids to advance automated intestinal organoid screening technology
Molecular Devices inks deal with HUB Organoids to advance automated intestinal organoid screening technology
SAN JOSE, Calif., and UTRECHT, Netherlands, Feb. 13, 2023 – Molecular Devices, LLC., a leading provider of high-performance life science solutions, and HUB Organoids (HUB), the pioneer…
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Blog
3D organoids and automation of complex cell assays [Podcast]
3D organoids and automation of complex cell assays [Podcast]
As we enter the era of sophisticated drug discovery with gene therapy and personalized medicine, we need to be prepared to study complex diseases, assess the therapeutic effect of…
Publications
Gene editing in organoids: accounting for complexity in drug discovery
Gene editing in organoids: accounting for complexity in drug discovery
More researchers are using gene editing to build disease models that better represent human tissues' complex biology, signaling a shift away from 2D cell culture or animal models to…
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Publications
Bioprinting Automation for Drug Discovery to Be Developed by Molecular Devices and Advanced Solutions
Bioprinting Automation for Drug Discovery to Be Developed by Molecular Devices and Advanced Solutions
3DPrint.com, the leading source for actionable intelligence related to 3D printing technology and the larger AM industry, covers our collaboration…
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Publications
Improving Drug Development: Molecular Devices and Cellesce Aim to Advance the Use of Organoids
Improving Drug Development: Molecular Devices and Cellesce Aim to Advance the Use of Organoids
Following our acquisition of Cellesce Ltd, Tanya Samazan from Instrument Business Outlook dove deep into conversation with Molecular Devices President Susan Murphy and Cellesce CEO V…
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News
Molecular Devices and Advanced Solutions Life Sciences collaborate to develop 3D Biology Automation Technologies for Drug Discovery
Molecular Devices and Advanced Solutions Life Sciences collaborate to develop 3D Biology Automation Technologies for Drug Discovery
Turnkey platform integrates flexible robotic automation with high-content imaging of complex 3D cellular models, enabling high-volume organoid screening SAN JOSE, Calif., Jan. 4, 2023…
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News
Molecular Devices adds proprietary patient-derived organoid technology with acquisition of Cellesce
Molecular Devices adds proprietary patient-derived organoid technology with acquisition of Cellesce
First-of-its-kind technology from Cellesce creates consistent patient-derived organoids for large scale drug screening Acquisition strengthens Molecular Devices’ position as a 3D…
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Publications
Overcoming ‘Analysis Paralysis’ in Cell Painting With Artificial Intelligence
Overcoming ‘Analysis Paralysis’ in Cell Painting With Artificial Intelligence
Gone are the days of only measuring single parameters in cell-based experiments. Instead, researchers should widen their focus, namely with the help of innovations like the Cell Pain…
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Publications
How cardioids can usher in the next generation of drug discovery
How cardioids can usher in the next generation of drug discovery
We recently partnered with HeartBeat.bio to automate and scale the production of cardioids — 3D cell models of the heart that can more accurately recapitulate human biology.
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Publications
What an innovation centre means for 3D biology
What an innovation centre means for 3D biology
In April 2021, we launched our Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process.…
Customer Breakthrough
Yashraj Biotechnology leverages the ImageXpress Nano to substantially improve their multi-parametric imaging and analyses
Yashraj Biotechnology leverages the ImageXpress Nano to substantially improve their multi-parametric imaging and analyses
Unexpected toxicity in areas such as cardiotoxicity, hepatotoxicity, and neurotoxicity is a serious complication of clinical therapy and one of the key causes for failure of promisin…
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Blog
Innovation at Molecular Devices: Updates in Automated, High-Content Imaging
Innovation at Molecular Devices: Updates in Automated, High-Content Imaging
From customer feedback to workflow improvements The path to understanding complex biological processes and diseases is paved with a lot of challenges. As the desired level of…
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Blog
Stem cell science insights and breakthroughs presented at #ISSCR2021
Stem cell science insights and breakthroughs presented at #ISSCR2021
If you didn't get a chance to visit us at our poster sessions during ISSCR 2021, don’t fret. We've gathered all our sessions right here for you. The ISSCR Annual Meeting brought…
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Blog
Tips for running a successful live cell imaging experiment
Tips for running a successful live cell imaging experiment
There have been significant advancements in microscopy and camera technology, as well as advancements in technologies for labeling molecules of interest over the past decade. These…
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Blog
Overcome the challenges of high-content cell analysis through AI/machine learning
Overcome the challenges of high-content cell analysis through AI/machine learning
Artificial intelligence (AI) is finding its way into many aspects of modern life, from autonomous vehicles to voice-powered personal assistants, and even the creation of art. But it…
Scientific Poster
Automated 3D cell-based assays using a novel flow chip system and high-content imaging
Automated 3D cell-based assays using a novel flow chip system and high-content imaging
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translation research. Significant progress has b…
eBook
Cellular Imaging Insights
Cellular Imaging Insights
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
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Blog
Life sciences technology predictions for 2021
Life sciences technology predictions for 2021
For over 40 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
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Blog
Get to know our Field Applications Scientist: Kayla Hill
Get to know our Field Applications Scientist: Kayla Hill
Kayla Hill discusses the latest trends in cellular imaging We recently hosted a webinar with our Field Applications Scientist, Kayla Hill, PhD, who explored high-content analysis…
Application Note
High-throughput screening of single-cell contractile force using FLECS Technology
High-throughput screening of single-cell contractile force using FLECS Technology
The ability of mammalian cells to generate mechanical forces—to push, pull, or squeeze—is an intrinsic capability that is used by cells both individually and together as tissue to…
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eBook
Quantitate Neuron Potential
Quantitate Neuron Potential
Gain valuable insights into neurobiology, from evaluation of ion channels to analysis of 3D neuron organoids.
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eBook
Phenotypic Screening With iPSC-Derived Cardiomyocytes and Neurons
Phenotypic Screening With iPSC-Derived Cardiomyocytes and Neurons
This new eBook discusses early drug safety testing using HTS iPSC-derived cells with imaging. Download it now!
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Application Note
Phenotypic characterization of anti-cancer drug effects using automated imaging
Phenotypic characterization of anti-cancer drug effects using automated imaging
Discovery and evaluation of anti-cancer therapies is an active area of research that includes development of cell-based models, screening for novel drugs, comparison of drug efficacy,…
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Application Note
Quantitate GPCR activation using automated cell imaging and analysis
Quantitate GPCR activation using automated cell imaging and analysis
GPCRs are the largest group of signal transducing transmembrane proteins, constituting roughly 4% of the proteincoding genome. They play integral roles in a wide range of biological…
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Application Note
Transmitted light image analysis for cell count and assessment of cytotoxicity effects
Transmitted light image analysis for cell count and assessment of cytotoxicity effects
Numerous biological applications require monitoring of cell number, cell health, confluency, and proliferation during multiple time points without fluorescent markers or other labels.…
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Application Note
Streamline assessment of DNA damage using the ImageXpress Nano system
Streamline assessment of DNA damage using the ImageXpress Nano system
Assessing damage to DNA or chromosomes is frequently addressed with research applications because of its implications in diverse diseases including genetic mutations, cancer, and aging…
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Application Note
Assessment of neurotoxicity and neuronal development using induced pluripotent stem cell-based neurite outgrowth assay
Assessment of neurotoxicity and neuronal development using induced pluripotent stem cell-based neurite outgrowth assay
Growing concerns about the increased prevalence of untested chemicals in the environment has created a pressing need to develop reliable and efficient screening tools to identify…
Brochure
Imaging Solutions to Answer Your Biological Questions
Imaging Solutions to Answer Your Biological Questions
Learn about our imaging family and which solution is best suited to answer your biological questions.
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Application Note
Phenotypic characterization of toxic compound effects on cardiomyocytes derived from induced pluripotent stem cells
Phenotypic characterization of toxic compound effects on cardiomyocytes derived from induced pluripotent stem cells
Cardiotoxicity remains a primary cause for drug attrition during clinical trials and post-marketing. While it is believed that a significant percentage of cardiovascular diseases are…
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Application Note
Assaying cardiotoxicity with ImageXpress high-content screening systems
Assaying cardiotoxicity with ImageXpress high-content screening systems
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the human physiological response in the…
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Application Note
Multiplexed high-content hepatotoxicity assays using iPSC-derived hepatocytes
Multiplexed high-content hepatotoxicity assays using iPSC-derived hepatocytes
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy testing are crucial for improving drug…
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Scientific Poster
In Vitro Cardiotoxicity and Neurotoxicity Assessment of Environmental Chemicals Using Organotypic Human Induced Pluripotent Stem Cell-Derived Models
In Vitro Cardiotoxicity and Neurotoxicity Assessment of Environmental Chemicals Using Organotypic Human Induced Pluripotent Stem Cell-Derived Models
An increased prevalence of neurological and cardiovascular disorders, possibly attributed to environmental toxicant exposures, has generated an interest in developing reliable and ef…
Flyer
ImageXpress Nano Automated Imaging System
ImageXpress Nano Automated Imaging System
The ImageXpress® Nano Automated Imaging System enables researchers to get better data faster and improve collaborations with peers – anywhere, anytime. Learn more about how this cost…
Videos & Webinars
Immunology and Vaccine Development Workflow
Hybridoma Workflow
Accelerate your screening with high-content and automated imaging
Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening
ImageXpress Nano High-Content Imaging System Virtual Tour
Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow
LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch
Plate annotation and curve fitting in MetaXpress
Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress
Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress
Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress
Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging
Number of Citations*: 56
Latest Citations: For a complete list, please click here .
*Source: https://scholar.google.com/
Dated: Jan 12, 2021Publication Name: Molecular Devices | Sunnyvale, CADetection of autophagy using automated imaging
Autophagy is a highly regulated process of degrading and recycling damaged proteins and organelles in response to cellular stress.1, 2 It is mediated by a unique vesicle called the autophagosome, which is assembled by the formation of a double membrane around the cellular component marked for destruction.1 The autophagosome vesicle then fuses with… View moreAutophagy is a highly regulated process of degrading and recycling damaged proteins and organelles in response to cellular stress.1, 2 It is mediated by a unique vesicle called the autophagosome, which is assembled by the formation of a double membrane around the cellular component marked for destruction.1 The autophagosome vesicle then fuses with the lysosome to deliver its contents for degradation by lysosomal hydrolases.
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Dated: Sep 25, 2018Publication Name: Platelets
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is… View moreThe MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is ambiguous as previous reports have been contradictory. It is therefore unclear if MEK inhibitors might be causing platelet dysfunction and contributing to increased hemorrhage. In the present study we performed pharmacological characterisation of cobimetinib and trametinib in vitro to investigate potential for MEK inhibitors to cause platelet dysfunction.
Contributors: Amanda J. Unsworth, Alexander P. Bye, Neline Kriek, Tanya Sage, Ashley A. Osborne, Dillon Donaghy & Jonathan M. Gibbins
Go to article -
Dated: Oct 27, 2017Publication Name: Cambridge University Press
Park NX12 Microscope for NanoScale Imaging
The Park NX12 is an inverted optical microscope based SPM platform for SICM, SECM, and SECCM, in addition to atomic force microscopy for research on a broad range of materials from organic to inorganic, transparent to opaque, and soft to hard. Park NX12 is suited for advanced research on materials such as membranes, organic devices and electronics… View moreThe Park NX12 is an inverted optical microscope based SPM platform for SICM, SECM, and SECCM, in addition to atomic force microscopy for research on a broad range of materials from organic to inorganic, transparent to opaque, and soft to hard. Park NX12 is suited for advanced research on materials such as membranes, organic devices and electronics, and biological and pathological samples in both air and liquid, plus a solution and platform for pipette-based SPM techniques.
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Featured Applications
3D Cell Models
3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including…
Cancer Research
Cancer researchers need tools that enable them to more easily study the complex and often poorly…
Cardiomyocytes
Stem cells differentiated into cardiomyocytes are used to screen early for potential toxicological…
Cell Counting
Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug…
Cell Migration Assays
The movement or migration of cells is often measured in vitro to elucidate the mechanisms of…
COVID-19 and Infectious Disease Research
Here we've addressed common applications in infectious disease research including cell line…
Live Cell Imaging
Live cell imaging is the study of cellular structure and function in living cells via microscopy.…
Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological…
Stem Cell Research
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a…
Toxicology
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It…
Customer Breakthrough
SUCCESS STORY
Yashraj Biotechnology leverages the ImageXpress Nano to substantially improve their multi-parametric imaging and analyses
How can we help advance your next big discovery?
Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?
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