- Cellular Imaging Systems
- High-Content Imaging
- ImageXpress Nano Automated Imaging System
ImageXpress Nano Automated Imaging System
High-content imaging system for your everyday biological needs
The ImageXpress® Nano Automated Imaging System features a long life, solid state, light engine, and optics to reliably deliver the right assay sensitivity. Capture fine details of a variety of cellular and subcellular assays with this powerful and flexible fluorescent microscopy solution. The system includes MetaXpress® High-Content Image Acquisition and Analysis Software with tools for 2D and 3D imaging and time lapse analysis, as well as a range of needs from ease-of-use through to proprietary assay design.
Brightfield imaging allows for rapid acquisition without the use of harmful fluorescent agents.
The modular toolbox in the MetaXpress® software allows for the quick setup of hundreds of routine assays. Choose from our optional selection of turnkey application modules for greater convenience.
With 2x to 60x magnification, the system offers the flexibility to image whole-well (C. elegans, zebrafish), as well as sub-cellular details (vesicles, organelles).
ImageXpress Nano High-Content Imaging System Virtual Tour
An entire well of a 384-well plate can be captured in a single image at 4x magnification for faster throughput.
Fully automated X, Y, and Z stages with resolution better than 25 nm.
The system can be configured with different filters or objectives (2-60x) to meet research needs.
The system can have up to 5 fluorescent filters installed at one time. The software allows up to 7 channels to be acquired at one time which enables multi-channel fluorescent and transmitted light imaging in one experiment.
Laser autofocus enables quick, consistent focusing across plates, slides and uneven surfaces.
Multi-day, time lapse and live cell assays can be run using the onboard environmental system with options for temprature, humidity, and CO2 control.
Turnkey platform integrates flexible robotic automation with high-content imaging of complex 3D cellular models, enabling high-volume organoid screening SAN JOSE, Calif…
3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
Stem cells differentiated into cardiomyocytes are used to screen early for potential toxicological effects of drugs, thus helping to avoid investment in development of drugs which will fail in clinical trials due to cardiac toxicity.
Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division rely on the assessment of the number or density of cells in a well.
The movement or migration of cells is often measured in vitro to elucidate the mechanisms of various physiological activities such as wound healing or cancer cell metastasis. Cell migration assays may be conducted in a controlled environment using live cell timelapse imaging.
Here we've addressed common applications in infectious disease research including cell line development, binding affinity, viral neutralization, viral titer and more with a focused effort on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19 including vaccines, therapeutics and diagnostics.
Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
Target discovery and drug development rely heavily on 2D cell and animal models to decipher efficacy and toxic effect of drug candidates. Yet, 90% of candidates fail to make it past…
SAN JOSE, Calif., and UTRECHT, Netherlands, Feb. 13, 2023 – Molecular Devices, LLC., a leading provider of high-performance life science solutions, and HUB Organoids (HUB), the pioneer…
As we enter the era of sophisticated drug discovery with gene therapy and personalized medicine, we need to be prepared to study complex diseases, assess the therapeutic effect of…
More researchers are using gene editing to build disease models that better represent human tissues' complex biology, signaling a shift away from 2D cell culture or animal models to…
3DPrint.com, the leading source for actionable intelligence related to 3D printing technology and the larger AM industry, covers our collaboration…
Following our acquisition of Cellesce Ltd, Tanya Samazan from Instrument Business Outlook dove deep into conversation with Molecular Devices President Susan Murphy and Cellesce CEO V…
Turnkey platform integrates flexible robotic automation with high-content imaging of complex 3D cellular models, enabling high-volume organoid screening SAN JOSE, Calif., Jan. 4, 2023…
First-of-its-kind technology from Cellesce creates consistent patient-derived organoids for large scale drug screening Acquisition strengthens Molecular Devices’ position as a 3D…
Gone are the days of only measuring single parameters in cell-based experiments. Instead, researchers should widen their focus, namely with the help of innovations like the Cell Pain…
We recently partnered with HeartBeat.bio to automate and scale the production of cardioids — 3D cell models of the heart that can more accurately recapitulate human biology.
In April 2021, we launched our Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process.…
Unexpected toxicity in areas such as cardiotoxicity, hepatotoxicity, and neurotoxicity is a serious complication of clinical therapy and one of the key causes for failure of promisin…
From customer feedback to workflow improvements The path to understanding complex biological processes and diseases is paved with a lot of challenges. As the desired level of…
If you didn't get a chance to visit us at our poster sessions during ISSCR 2021, don’t fret. We've gathered all our sessions right here for you. The ISSCR Annual Meeting brought…
There have been significant advancements in microscopy and camera technology, as well as advancements in technologies for labeling molecules of interest over the past decade. These…
Artificial intelligence (AI) is finding its way into many aspects of modern life, from autonomous vehicles to voice-powered personal assistants, and even the creation of art. But it…
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translation research. Significant progress has b…
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
For over 40 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
Kayla Hill discusses the latest trends in cellular imaging We recently hosted a webinar with our Field Applications Scientist, Kayla Hill, PhD, who explored high-content analysis…
The ability of mammalian cells to generate mechanical forces—to push, pull, or squeeze—is an intrinsic capability that is used by cells both individually and together as tissue to…
Gain valuable insights into neurobiology, from evaluation of ion channels to analysis of 3D neuron organoids.
This new eBook discusses early drug safety testing using HTS iPSC-derived cells with imaging. Download it now!
Discovery and evaluation of anti-cancer therapies is an active area of research that includes development of cell-based models, screening for novel drugs, comparison of drug efficacy,…
GPCRs are the largest group of signal transducing transmembrane proteins, constituting roughly 4% of the proteincoding genome. They play integral roles in a wide range of biological…
Numerous biological applications require monitoring of cell number, cell health, confluency, and proliferation during multiple time points without fluorescent markers or other labels.…
Assessing damage to DNA or chromosomes is frequently addressed with research applications because of its implications in diverse diseases including genetic mutations, cancer, and aging…
Growing concerns about the increased prevalence of untested chemicals in the environment has created a pressing need to develop reliable and efficient screening tools to identify…
Learn about our imaging family and which solution is best suited to answer your biological questions.
Cardiotoxicity remains a primary cause for drug attrition during clinical trials and post-marketing. While it is believed that a significant percentage of cardiovascular diseases are…
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the human physiological response in the…
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy testing are crucial for improving drug…
An increased prevalence of neurological and cardiovascular disorders, possibly attributed to environmental toxicant exposures, has generated an interest in developing reliable and ef…
The ImageXpress® Nano Automated Imaging System enables researchers to get better data faster and improve collaborations with peers – anywhere, anytime. Learn more about how this cost…
Immunology and Vaccine Development Workflow
Accelerate your screening with high-content and automated imaging
Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening
ImageXpress Nano High-Content Imaging System Virtual Tour
Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow
LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch
Plate annotation and curve fitting in MetaXpress
Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress
Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress
Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress
Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging
Latest Citations: For a complete list, please click here .
Autophagy is a highly regulated process of degrading and recycling damaged proteins and organelles in response to cellular stress.1, 2 It is mediated by a unique vesicle called the autophagosome, which is assembled by the formation of a double membrane around the cellular component marked for destruction.1 The autophagosome vesicle then fuses with the lysosome to deliver its contents for degradation by lysosomal hydrolases.
The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone. Platelets express several members of the MAPK signalling cascade including MEK1 and MEK2 and ERK1 and ERK2 but their role in platelet function and haemostasis is ambiguous as previous reports have been contradictory. It is therefore unclear if MEK inhibitors might be causing platelet dysfunction and contributing to increased hemorrhage. In the present study we performed pharmacological characterisation of cobimetinib and trametinib in vitro to investigate potential for MEK inhibitors to cause platelet dysfunction.
The Park NX12 is an inverted optical microscope based SPM platform for SICM, SECM, and SECCM, in addition to atomic force microscopy for research on a broad range of materials from organic to inorganic, transparent to opaque, and soft to hard. Park NX12 is suited for advanced research on materials such as membranes, organic devices and electronics, and biological and pathological samples in both air and liquid, plus a solution and platform for pipette-based SPM techniques.