ImageXpress HCS.ai High-Content Screening System
A fast, intuitive and versatile system delivering deeper insights for every lab
Deeper insights for every lab
The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the crystal-clear images and robust data you need with ease.
Powered by intuitive MetaXpress® Acquire software, the ImageXpress HCS.ai system integrates seamlessly with AI-driven IN Carta® Image Analysis Software for deep insights. An advanced, modular design offers the flexibility to perform a vast range of 2D and 3D assays in a single solution, while allowing for easy upgrades to meet evolving laboratory needs.
Modular and intuitive for optimal versatility
The ImageXpress HCS.ai system features a modular design and a wide array of customizable configuration options to meet your current needs and on-site upgrades to match your future requirements. The newly upgraded MetaXpress® Acquire software is an intuitive solution for users of all experience levels, providing direct access to reliable and insightful data.
Higher quality images and superior data analysis for deeper insights
Acquire high-quality images across a vast range of assay types, obtain exceptional image quality from your 3D samples, and unlock new discoveries with AI-powered IN Carta® Image Analysis Software.
Faster acquisition for accelerated high-throughput workflows
Boost lab productivity by imaging more plates in less time and simplifying the learning curve for new users. A new, automation friendly design enables you to integrate easily into automated workflows for faster, more reliable results.
Discover the new ImageXpress HCS.ai High-Content Screening System
Features
Multiple imaging modes
The system offers brightfield label-free imaging, widefield and confocal fluorescent imaging.
Automated water immersion objective technology option
Offers greater image resolution and sensitivity with up to 4x increase in signal, which leads to lower exposure times.
Streamlined upgrade pathway
The modular design enables additional capabilities to be easily added to your system, allowing easy upgrades as your needs evolve.
Exclusive AgileOptix™ spinning disk technology
Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.
High-intensity laser light source option
The option of laser illumination enables you to capture images faster with shorter exposure times and multiplex your experiments with 7 lasers and 8 imaging channels.
Magnification changer option
Get access to 12 magnifications within a single configuration, including high NA (Numerical Aperture) and ELWD (Extra-Long Working Distance) options.
MetaXpress® Acquire Software
The MetaXpress® Acquire acquisition package streamlines complex workflows—new users can get started quickly, whereas advanced users can leverage its flexibility to create optimized protocols.
AI-powered IN Carta® image analysis software
Leverages machine-learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.
Scalable walkaway automation: Flexible solutions for high-content screening with ImageXpress HCS.ai system
For laboratories beginning their automation journey, Molecular Devices offers flexible, scalable solutions that simplify the transition to automated high-content screening workflows. Starter automation options—such as walkaway automation for the ImageXpress® HCS.ai High-content Screening System—streamline plate handling and integrate advanced imaging with AI-powered analysis. With this system, you can image more plates in less time—processing 40 microtiter plates (96-well format) in just 2 hours, or 80 plates in 4 hours, all with complete hands-off operation. This approach boosts throughput, ensures high data quality, and minimizes manual steps. As your research evolves, these modular systems scale from basic plate handling to fully integrated, customized workcells—delivering consistent, reproducible results with optimized efficiency.
Key advantages of scalable lab automation
- Walkaway efficiency: Process hundreds of plates unattended—freeing up valuable lab time.
- Higher throughput, better reproducibility: Automated imaging ensures consistent, reliable results.
- Modular and scalable: Expand your system as your research grows.
- Seamless integration: Compatible with your preferred software and lab setup.
- Future-ready: Upgrade easily with new capabilities as they emerge.
Ready to accelerate your research?
Download the flyer to see how scalable automation can transform your lab workflow.
Latest Resources
Featured Applications
