High-content image analysis software featuring time lapse analysis

MetaXpress® High-Content Image Acquisition and Analysis Software is a comprehensive solution for high-content analysis featuring a tightly orchestrated and integrated workflow. The portfolio of application modules supports a range of needs from ease-of-use through to proprietary assay design. The software includes powerful and elegant tools for 2D and 3D imaging such as time lapse analysis. With the assistance of our acquisition setup wizard, you’ll be generating data in minutes.

  • Acquire and analyze in 2D and 3D

    Acquire and analyze in 2D and 3D

    MetaXpress software is a platform for 2D and 3D image acquisition and analysis. The 3D Image Analysis Module can analyze spheroids, microtissues, cells in a 3D matrix, and small organisms.

  • Streamline image analysis

    Streamline image analysis

    The modular toolbox allows for the quick setup of hundreds of routinely used high-content assays. Choose from our optional selections of turnkey application modules for greater convenience.

  • Design custom analyses easily

    Design custom analyses easily

    Quickly create multi-step routines with the Custom Module Editor. It enables advanced analyses such as identifying objects within objects, and creating morphometric classifiers for shape analysis.

Introducing the MetaXpress 3D Analysis Toolkit

Introducing the MetaXpress 3D Analysis Toolkit

Features

  • Z-stacks and 3D volumetric analysis

    The integrated acquisition and analysis application modules for 3D cell models simplify high-throughput quantification of 3D structures with volume, intensity, and distance measurements.

  • Fast acquisition and analysis

    Easily captures fast biological functions with our patented fast frame rate that can capture 50 frames per second. A 1-color, 384-well plate analysis can be performed in a little as six minutes.

  • Intelligent segmentation

    Application modules feature turnkey image segmentation for label-free and fluorescently labeled images. The Custom Module Editor offers advanced tools for improved segmentation.

  • Scalable parallel processing

    MetaXpress PowerCore™ Software runs analysis routines in minutes. This optional module leverages the power of parallel processing to accelerate analysis.

  • Data management solution

    MDCStore™ Data Manager, included with MetaXpress software, organizes images, experimental information, and data analysis. It enables seamless manipulation of complex sets of images and metadata.

  • Advanced informatics

    AcuityXpress™ High-Content Informatics Software is an optional enterprise level platform for advanced data mining, analysis, statistics, and visualization. It shares the MDCStore database for seamless integration.

 Turnkey solutions for most common analysis routines

MetaXpress Application Modules

Expedite image analysis and data processing using our MetaXpress software with application modules that allow you to quickly and easily analyze your data:

  • Micronuclei
  • Neurite Outgrowth
  • Angiogenesis Tube Formation
  • Mitotic Index
  • Plus many more applications...

View Modules

MetaXpress Application Modules

 

MetaXpress Software Application Modules

Set up hundreds of routinely used HCS assays whether you’re a novice or an expert. MetaXpress software application modules give you an interactive environment to quantify 2D and 3D measurements, including size, intensities, and distance.

 

  • Angiogenesis Tube Formation

    Angiogenesis Tube Formation Application Module

    Angiogenesis Tube Formation Application Module facilitates the analysis of tube formation, a model experimental system for angiogenesis. The promotion or inhibition of blood vessel formation is one focus for cancer, diabetes and other vascular disease research.

    Read Application Note  

    Cell Cycle

    Cell Cycle Application Module

    Cell Cycle Application Module classifies and quantifies cells in various stages of the cell cycle to investigate cell cycle progression. In healthy non-cancerous cells, challenges with DNA damage, hypoxia, metabolic changes or spindle disruption result in the triggering of checkpoints and cell cycle arrest. Cancerous cells commonly lose checkpoints and divide uncontrollably, even in challenging conditions. With the appropriate tools, researchers can screen for drugs that cause cell cycle arrest or cell death in cancerous cells.

    Download Datasheet  

  • Cell Health

    Cell Health Application Module

    Cell Health Application Module classifies cells states in viable, early apoptosis, late apoptosis or necrosis.

    Download Datasheet  

    Cell Proliferation High-Throughput

    Cell Proliferation High-Throughput Application Modules

    Cell Proliferation HT Application Module is a high throughput version of the Count Nuclei, (about 1 minute for 96-well plate at one site per well without the MetaXpress® PowerCore™ Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.

    Download Datasheet 

  • Cell Scoring

    Cell Scoring Application Module

    Cell Scoring Application Module is a general and flexible solution to identify subpopulations of cells tagged with a second fluorescent probe and is ideal for examining transfection efficiencies, pathway activation (kinases) or adipogenesis.

    Download Datasheet  

    Count Nuclei

    Count Nuclei Application Module

    Count Nuclei Application Modules automate accurate counting of nuclei for most types of cells and are ideal for the study of cell proliferation, cell counting or cell migration. This module counts nuclei even when the background is uneven, providing superior segmentation compared to simple thresholding.

    Download Datasheet  

  • Granularity and Transfluor

    Granularity, Transfluor And Transfluor HT Application Modules

    Granularity and Transfluor Application Module facilitate the analysis of punctate structures such as the one observed during clustering of target molecules for receptor internalization or within the nucleus or even the punctate patterns of mitochondria or other organelles.

    Download Datasheet  

    Live/Dead

    Live/Dead Application Module

    Live Dead Application Module is compatible with commercially available Live/Dead assay kits designed to study cell proliferation or death. Common applications monitor cell proliferation associated with cancer or cell death due to neuromuscular diseases such as Alzheimer's and Parkinson's Disease or in response to cytotoxic and apoptotic events.

    Download Datasheet  

  • Micronuclei

    Micronuclei Application Module

    Micronuclei Application Module classifies cells based on nuclear morphology for genotoxicity applications but is also ideal for cell health or multi-nucleated cell populations with additional markers for analysis of apoptosis, necrosis or to distinguish any small structure next to a large one such as a yeast bud.

    Download Datasheet  

    Mitotic Index

    Mitotic Index Application Module

    Mitotic Index Application Module is designed for the quantitative discrimination of mitotic and interphase cells, a critical tool for oncology drug discovery programs, providing insight into potential anti-cancer therapeutics that rely on arresting mitosis in cancerous cells to prevent uncontrolled proliferation.

    Download Datasheet  

  • Monopole Detection

    Monopole Detection Application Module

    Monopole Detection Application Module monitors the disruption of the formation of bipolar spindles, a successful mechanism used by drugs such monastol to stop the progression of cancerous cells through mitosis. The module quantifies mitotic cells with monopolar or bipolar spindles in cells stained with a DNA probe and a microtubule probe.

    Download Datasheet  

    Multi-Wavelength Cell Scoring

    Multi-Wavelength Cell Scoring Application Module

    Multi-Wavelength Cell Scoring Application Module enhances the functionality of the Cell Scoring Application Module to include additional wavelengths to score populations of cells based on numerous labels.

    Download Datasheet  

  • Multi-Wavelength Translocation

    Multi-Wavelength Translocation Application Module

    The Multi-Wavelength Translocation Application Module lets you analyze the translocation of up to 6 probes simultaneously (or the same probes with various settings), in addition to the nuclear stain.

    Download Datasheet 

    Neurite Outgrowth

    Multi-Wavelength Translocation Application Module

    Neurite Outgrowth Application Module is designed to measure and characterize outgrowths, the extension of processes from the cell body, which are natural parts of neuronal development. Inhibition or stimulation of neurite outgrowth is implicated in a broad range of neurological disorders or injuries including stroke, Parkinson's disease, Alzheimer's disease, and spinal cord injuries.

    Download Flyer  

  • Nuclear Translocation High-Throughput

    Nuclear Translocation High-Throughput Application Module

    Nuclear Translocation HT Application Module is for the fast analysis of translocation in and out of the nuclear compartment (about 1 minute for 96-well plate at one site per well without MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.

    Download Datasheet  

    Transfluor High-Throughput

    Transfluor High-Throughput Application Module

    Transfluor HT Application Module is a high throughput version of the Granularity Application Module for fast screening (about 1 minute for 96-well plate at one site per well without the MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.

    Download Datasheet 

  • Translocation and Translocation-Enhanced

    Translocation and Translocation-Enhanced Application Modules

    Translocation and Translocation-Enhanced Application Modules quantify the correlation between probes and compartments. Translocation is ideal for studying general cellular component movement from the cytoplasm to the nucleus with a minimum number of adjustments. While Translocation-Enhanced offers increased functionality with finer definition of regions for translocation and the option to study translocation in non-nuclear compartments such as mitochondria.

    Download Datasheet  

Resources of MetaXpress High-Content Image Acquisition and Analysis Software

Videos and Demos

High-Content Screening for Identifying miRNAs

High-Content Screening for Identifying miRNAs

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Oliver Kepp and Jayne Hesley - Detect Cell Death Signatures with High Content Imaging

Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging

Multidimensional ImageXpress Micro Confocal System

Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System

Pushing the Boundaries of High Content Screening

Pushing the Boundaries of High Content Screening

Preparing Assays for Genome-wide RNAi Screens

Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy

Multiplexed High Content Hepatoxicity Assays

Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models

Simple and Flexible High Content Imaging of Complex Biological Events

Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events

Contemporary Automation and High Content Imaging Tools

Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes

3D Image Analysis from Subcellular Structures to Spheroids

Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids

Live Cell Imaging to Investigate Cell Division Timing

Live Cell Imaging to Investigate the Regulation of Cell Division Timing

High-throughput RNA Screening to Identify Host Factors

Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection

Application of HCA Tools for Antibody Drug Discovery

Application of HCA Tools for Antibody Drug Discovery

3D Spheroid Assays Using High-Content Imaging

Setting up 3D Spheroid Assays Using High-Content Imaging

Pluripotent Stem Cell Applications in Drug Discovery

Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery

Related Products & Services of MetaXpress High-Content Image Acquisition and Analysis Software

Featured Applications

Customer Breakthrough

Hapix hcs phrama
Hapix hcs phrama

SUCCESS STORY

HCS Pharma uses ImageXpress Micro Confocal Systems for phenotypic screening of physiologically relevant 3D cell models

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Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Maximize flexibility in application workflow and experimental design

Contact our specialist today to discuss how to implement a solution that works for you

Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Maximize flexibility in application workflow and experimental design

Contact our specialist today to discuss how to implement a solution that works for you