High-content image analysis software featuring time lapse analysis
MetaXpress® High-Content Image Acquisition and Analysis Software is a comprehensive solution for high-content analysis featuring a tightly orchestrated and integrated workflow. The portfolio of application modules supports a range of needs from ease-of-use through to proprietary assay design. The software includes powerful and elegant tools for 2D and 3D imaging such as time lapse analysis. With the assistance of our acquisition setup wizard, you’ll be generating data in minutes.
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Acquire and analyze in 2D and 3D
MetaXpress software is a platform for 2D and 3D image acquisition and analysis. The 3D Image Analysis Module can analyze spheroids, microtissues, cells in a 3D matrix, and small organisms.
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Streamline image analysis
The modular toolbox allows for the quick setup of hundreds of routinely used high-content assays. Choose from our optional selections of turnkey application modules for greater convenience.
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Design custom analyses easily
Quickly create multi-step routines with the Custom Module Editor. It enables advanced analyses such as identifying objects within objects, and creating morphometric classifiers for shape analysis.
Introducing the MetaXpress 3D Analysis Toolkit
Features
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Z-stacks and 3D volumetric analysis
The integrated acquisition and analysis application modules for 3D cell models simplify high-throughput quantification of 3D structures with volume, intensity, and distance measurements.
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Fast acquisition and analysis
Easily captures fast biological functions with our patented fast frame rate that can capture 50 frames per second. A 1-color, 384-well plate analysis can be performed in a little as six minutes.
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Intelligent segmentation
Application modules feature turnkey image segmentation for label-free and fluorescently labeled images. The Custom Module Editor offers advanced tools for improved segmentation.
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Scalable parallel processing
MetaXpress PowerCore™ Software runs analysis routines in minutes. This optional module leverages the power of parallel processing to accelerate analysis.
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Data management solution
MDCStore™ Data Manager, included with MetaXpress software, organizes images, experimental information, and data analysis. It enables seamless manipulation of complex sets of images and metadata.
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Advanced informatics
AcuityXpress™ High-Content Informatics Software is an optional enterprise level platform for advanced data mining, analysis, statistics, and visualization. It shares the MDCStore database for seamless integration.
Turnkey solutions for most common analysis routines
MetaXpress Application Modules
Expedite image analysis and data processing using our MetaXpress software with application modules that allow you to quickly and easily analyze your data:
- Micronuclei
- Neurite Outgrowth
- Angiogenesis Tube Formation
- Mitotic Index
- Plus many more applications...
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Application Note
Custom Module Editor For MetaXpress High Content Image Acquisition and Analysis Software
Custom Module Editor For MetaXpress High Content Image Acquisition and Analysis Software
The Custom Module Editor in version 5 of MetaXpress® Software is a flexible, interactive environment where users can create and test a template for image analysis. Galleries of processing…
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Brochure
MetaXpress High-Content Image Acquisition and Analysis Software
MetaXpress High-Content Image Acquisition and Analysis Software
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At Molecular Devices, we’re inspired by your cr…
MetaXpress Software Application Modules
Set up hundreds of routinely used HCS assays whether you’re a novice or an expert. MetaXpress software application modules give you an interactive environment to quantify 2D and 3D measurements, including size, intensities, and distance.
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Angiogenesis Tube Formation
Angiogenesis Tube Formation Application Module facilitates the analysis of tube formation, a model experimental system for angiogenesis. The promotion or inhibition of blood vessel formation is one focus for cancer, diabetes and other vascular disease research.
Angiogenesis Tube Formation
Angiogenesis Tube Formation Application Module facilitates the analysis of tube formation, a model experimental system for angiogenesis. The promotion or inhibition of blood vessel formation is one focus for cancer, diabetes and other vascular disease research.
Cell Cycle
Cell Cycle Application Module classifies and quantifies cells in various stages of the cell cycle to investigate cell cycle progression. In healthy non-cancerous cells, challenges with DNA damage, hypoxia, metabolic changes or spindle disruption result in the triggering of checkpoints and cell cycle arrest. Cancerous cells commonly lose checkpoints and divide uncontrollably, even in challenging conditions. With the appropriate tools, researchers can screen for drugs that cause cell cycle arrest or cell death in cancerous cells.
Cell Cycle
Cell Cycle Application Module classifies and quantifies cells in various stages of the cell cycle to investigate cell cycle progression. In healthy non-cancerous cells, challenges with DNA damage, hypoxia, metabolic changes or spindle disruption result in the triggering of checkpoints and cell cycle arrest. Cancerous cells commonly lose checkpoints and divide uncontrollably, even in challenging conditions. With the appropriate tools, researchers can screen for drugs that cause cell cycle arrest or cell death in cancerous cells.
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Cell Health
Cell Health Application Module classifies cells states in viable, early apoptosis, late apoptosis or necrosis.
Cell Health
Cell Health Application Module classifies cells states in viable, early apoptosis, late apoptosis or necrosis.
Cell Proliferation High-Throughput
Cell Proliferation HT Application Module is a high throughput version of the Count Nuclei, (about 1 minute for 96-well plate at one site per well without the MetaXpress® PowerCore™ Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
Cell Proliferation High-Throughput
Cell Proliferation HT Application Module is a high throughput version of the Count Nuclei, (about 1 minute for 96-well plate at one site per well without the MetaXpress® PowerCore™ Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
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Cell Scoring
Cell Scoring Application Module is a general and flexible solution to identify subpopulations of cells tagged with a second fluorescent probe and is ideal for examining transfection efficiencies, pathway activation (kinases) or adipogenesis.
Cell Scoring
Cell Scoring Application Module is a general and flexible solution to identify subpopulations of cells tagged with a second fluorescent probe and is ideal for examining transfection efficiencies, pathway activation (kinases) or adipogenesis.
Count Nuclei
Count Nuclei Application Modules automate accurate counting of nuclei for most types of cells and are ideal for the study of cell proliferation, cell counting or cell migration. This module counts nuclei even when the background is uneven, providing superior segmentation compared to simple thresholding.
Count Nuclei
Count Nuclei Application Modules automate accurate counting of nuclei for most types of cells and are ideal for the study of cell proliferation, cell counting or cell migration. This module counts nuclei even when the background is uneven, providing superior segmentation compared to simple thresholding.
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Granularity and Transfluor
Granularity and Transfluor Application Module facilitate the analysis of punctate structures such as the one observed during clustering of target molecules for receptor internalization or within the nucleus or even the punctate patterns of mitochondria or other organelles.
Granularity and Transfluor
Granularity and Transfluor Application Module facilitate the analysis of punctate structures such as the one observed during clustering of target molecules for receptor internalization or within the nucleus or even the punctate patterns of mitochondria or other organelles.
Live/Dead
Live Dead Application Module is compatible with commercially available Live/Dead assay kits designed to study cell proliferation or death. Common applications monitor cell proliferation associated with cancer or cell death due to neuromuscular diseases such as Alzheimer's and Parkinson's Disease or in response to cytotoxic and apoptotic events.
Live/Dead
Live Dead Application Module is compatible with commercially available Live/Dead assay kits designed to study cell proliferation or death. Common applications monitor cell proliferation associated with cancer or cell death due to neuromuscular diseases such as Alzheimer's and Parkinson's Disease or in response to cytotoxic and apoptotic events.
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Micronuclei
Micronuclei Application Module classifies cells based on nuclear morphology for genotoxicity applications but is also ideal for cell health or multi-nucleated cell populations with additional markers for analysis of apoptosis, necrosis or to distinguish any small structure next to a large one such as a yeast bud.
Micronuclei
Micronuclei Application Module classifies cells based on nuclear morphology for genotoxicity applications but is also ideal for cell health or multi-nucleated cell populations with additional markers for analysis of apoptosis, necrosis or to distinguish any small structure next to a large one such as a yeast bud.
Mitotic Index
Mitotic Index Application Module is designed for the quantitative discrimination of mitotic and interphase cells, a critical tool for oncology drug discovery programs, providing insight into potential anti-cancer therapeutics that rely on arresting mitosis in cancerous cells to prevent uncontrolled proliferation.
Mitotic Index
Mitotic Index Application Module is designed for the quantitative discrimination of mitotic and interphase cells, a critical tool for oncology drug discovery programs, providing insight into potential anti-cancer therapeutics that rely on arresting mitosis in cancerous cells to prevent uncontrolled proliferation.
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Monopole Detection
Monopole Detection Application Module monitors the disruption of the formation of bipolar spindles, a successful mechanism used by drugs such monastol to stop the progression of cancerous cells through mitosis. The module quantifies mitotic cells with monopolar or bipolar spindles in cells stained with a DNA probe and a microtubule probe.
Monopole Detection
Monopole Detection Application Module monitors the disruption of the formation of bipolar spindles, a successful mechanism used by drugs such monastol to stop the progression of cancerous cells through mitosis. The module quantifies mitotic cells with monopolar or bipolar spindles in cells stained with a DNA probe and a microtubule probe.
Multi-Wavelength Cell Scoring
Multi-Wavelength Cell Scoring Application Module enhances the functionality of the Cell Scoring Application Module to include additional wavelengths to score populations of cells based on numerous labels.
Multi-Wavelength Cell Scoring
Multi-Wavelength Cell Scoring Application Module enhances the functionality of the Cell Scoring Application Module to include additional wavelengths to score populations of cells based on numerous labels.
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Multi-Wavelength Translocation
The Multi-Wavelength Translocation Application Module lets you analyze the translocation of up to 6 probes simultaneously (or the same probes with various settings), in addition to the nuclear stain.
Multi-Wavelength Translocation
The Multi-Wavelength Translocation Application Module lets you analyze the translocation of up to 6 probes simultaneously (or the same probes with various settings), in addition to the nuclear stain.
Neurite Outgrowth
Neurite Outgrowth Application Module is designed to measure and characterize outgrowths, the extension of processes from the cell body, which are natural parts of neuronal development. Inhibition or stimulation of neurite outgrowth is implicated in a broad range of neurological disorders or injuries including stroke, Parkinson's disease, Alzheimer's disease, and spinal cord injuries.
Neurite Outgrowth
Neurite Outgrowth Application Module is designed to measure and characterize outgrowths, the extension of processes from the cell body, which are natural parts of neuronal development. Inhibition or stimulation of neurite outgrowth is implicated in a broad range of neurological disorders or injuries including stroke, Parkinson's disease, Alzheimer's disease, and spinal cord injuries.
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Nuclear Translocation High-Throughput
Nuclear Translocation HT Application Module is for the fast analysis of translocation in and out of the nuclear compartment (about 1 minute for 96-well plate at one site per well without MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
Nuclear Translocation High-Throughput
Nuclear Translocation HT Application Module is for the fast analysis of translocation in and out of the nuclear compartment (about 1 minute for 96-well plate at one site per well without MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
Transfluor High-Throughput
Transfluor HT Application Module is a high throughput version of the Granularity Application Module for fast screening (about 1 minute for 96-well plate at one site per well without the MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
Transfluor High-Throughput
Transfluor HT Application Module is a high throughput version of the Granularity Application Module for fast screening (about 1 minute for 96-well plate at one site per well without the MetaXpress PowerCore Software) with a simplified detection algorithm, which provides site summary data only (not cell-by-cell) and does not save segmentation overlays to the MDCStore Database.
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Translocation and Translocation-Enhanced
Translocation and Translocation-Enhanced Application Modules quantify the correlation between probes and compartments. Translocation is ideal for studying general cellular component movement from the cytoplasm to the nucleus with a minimum number of adjustments. While Translocation-Enhanced offers increased functionality with finer definition of regions for translocation and the option to study translocation in non-nuclear compartments such as mitochondria.
Translocation and Translocation-Enhanced
Translocation and Translocation-Enhanced Application Modules quantify the correlation between probes and compartments. Translocation is ideal for studying general cellular component movement from the cytoplasm to the nucleus with a minimum number of adjustments. While Translocation-Enhanced offers increased functionality with finer definition of regions for translocation and the option to study translocation in non-nuclear compartments such as mitochondria.
Resources of MetaXpress High-Content Image Acquisition and Analysis Software
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Application Note
Custom Module Editor For MetaXpress High Content Image Acquisition and Analysis Software
Custom Module Editor For MetaXpress High Content Image Acquisition and Analysis Software
The Custom Module Editor in version 5 of MetaXpress® Software is a flexible, interactive environment where users can create and test a template for image analysis. Galleries of…
-
Brochure
MetaXpress High-Content Image Acquisition and Analysis Software
MetaXpress High-Content Image Acquisition and Analysis Software
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At Molecular Devices, we’re inspired by yo…
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Brochure
3D Image Analysis Module
3D Image Analysis Module
Complex assays and three-dimensional cell models better represent tissue biology and cell interactions, making them more relevant for many toxicity and drug screening assays. The abilit…
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Application Note
High-throughput screening of single-cell contractile force using FLECS Technology
High-throughput screening of single-cell contractile force using FLECS Technology
The ability of mammalian cells to generate mechanical forces—to push, pull, or squeeze—is an intrinsic capability that is used by cells both individually and together as tissue to…
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Application Note
Counting cells with the Transmitted Light Analysis Module in MetaXpress
Counting cells with the Transmitted Light Analysis Module in MetaXpress
Label-free cellular assays are required for a multitude of biological applications that monitor the cell number, proliferation, health, confluency, and cytotoxicity. In this…
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Application Note
Analyze experimental results using curve fitting with MetaXpress 6.5 software
Analyze experimental results using curve fitting with MetaXpress 6.5 software
The ability to annotate your plate, plot your data into a graph, and produce a variety of curves and readouts including IC50 values and benchmark dose or concentration for your…
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Application Note
High-content analysis of the various stages of apoptosis with the MetaXpress Cell Health Application Module
High-content analysis of the various stages of apoptosis with the MetaXpress Cell Health Application Module
Cell-based assays provide an efficient method of modeling the toxicological effects of drugs and for discriminating anti-proliferative effects from induction of apoptosis or necrosis.…
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Application Note
High-Content Screening of GPCR activation Using MetaXpress and AcuityXpress Software and the Transfluor Assay System
High-Content Screening of GPCR activation Using MetaXpress and AcuityXpress Software and the Transfluor Assay System
G-protein coupled receptors (GPCRs are the largest class of pharmaceutical targets and, as a result, assays for detecting GPCR receptor agonists and antagonists play a major role in…
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Application Note
MetaXpress Software Angiogenesis Application Module
MetaXpress Software Angiogenesis Application Module
Angiogenesis is the growth of new blood vessels and is an important natural process occurring in the body, both in health and disease. Angiogenesis occurs in the healthy body for…
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Application Note
Intelligent time-lapse imaging to enhance live cell assay development
Intelligent time-lapse imaging to enhance live cell assay development
The ability to monitor responses in living cells over a specific period of time offers cell biologists several key advantages for assay development. For routine cellbased screening,…
Data Sheet
MetaXpress Software High-Throughput Application Modules
MetaXpress Software High-Throughput Application Modules
MetaXpress is high throughput module that accelerates image-based screening process & is used in conjunction by corresponding research modules for cell-by-cell data mining.
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Data Sheet
MetaXpress Software Count Nuclei Application Module
MetaXpress Software Count Nuclei Application Module
Count Nuclei is designed to automate accurate counting of most types of cells. This is a user-friendly module to minimize set-up efforts & provides flexibility to customize the sett…
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Data Sheet
MetaXpress Software Multi-Wavelength Cell Scoring Application Module
MetaXpress Software Multi-Wavelength Cell Scoring Application Module
Multi-Wavelength Cell scoring datasheet describes the MetaXpress App Module that makes a number of additional cell-by-cell measurements including per-wavelength count.
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Data Sheet
MetaXpress Software Cell Scoring Application Module
MetaXpress Software Cell Scoring Application Module
Get an overview of Cell Scoring Application designed to identify two subpopulations of cells & to make a number of measurements including the number & percentage of cells.
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Data Sheet
MetaXpress Software Monopole Detection Application Module
MetaXpress Software Monopole Detection Application Module
The PDF defines Monopole Detection Module designed for quantitation of mitotic cells with monopolar or bipolar spindles.
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Data Sheet
MetaXpress Software Cell Cycle Application Module
MetaXpress Software Cell Cycle Application Module
This Cell Cycle datasheet provides an overview of the MetaXpress App Module. It is designed for the quantitation of cell cycle stage for cells labeled with a DNA stain.
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Data Sheet
MetaXpress Software Mitotic Index Application Module
MetaXpress Software Mitotic Index Application Module
Explore Mitotic Index datasheet to get information about MetaXpress App Module designed for quantitative discrimination of mitotic & interphase cells.
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Data Sheet
Digital Confocal Option
Digital Confocal Option
Get details about digital confocal option for ImageXpress MicroImaging Systems that enhance image contrast during acquisition & allow decreasing exposure time to maintain assay qual…
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Data Sheet
MetaXpress Software Micronuclei Application Module
MetaXpress Software Micronuclei Application Module
Get details about MetaXpress Application Module Micronuclei which includes cell cycle analysis, cell health profiling, live/dead determination, and mitotic index calculation.
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Data Sheet
MetaXpress Software Translocation Application Modules
MetaXpress Software Translocation Application Modules
The Translocation and Translocation-Enhanced Application Modules for MetaXpress® Software from Molecular Devices compliments the suite of application modules for the quantification of c…
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Data Sheet
MetaXpress Software Multi-Wavelength Translocation Application Module
MetaXpress Software Multi-Wavelength Translocation Application Module
Multi-Wavelength Translocation Module is designed for the combination, or multiplexing, of multiple translocating probes into a single assay. Explore this document to know more.
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Data Sheet
MetaXpress Software Cell Health Application Module
MetaXpress Software Cell Health Application Module
This datasheet shows Cell-based assays that provide an efficient method of modeling toxicological effects of drugs & for discriminating anti-proliferative effects.
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Data Sheet
MetaXpress Software Transfluor Application Module
MetaXpress Software Transfluor Application Module
The Transfluor Application Module for MetaXpress® Software from Molecular Devices is designed to facilitate the analysis of receptor internalization specifically for the Transfluor assa…
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Data Sheet
MetaXpress Software Live/Dead Application Module
MetaXpress Software Live/Dead Application Module
This LiveDead datasheet describes MetaXpress App Module is designed to automate the accurate identification of cells after staining with a variety of live/dead staining kit.
eBook
Cellular Imaging Insights
Cellular Imaging Insights
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
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eBook
Acquire and analyze 3D images like a pro
Acquire and analyze 3D images like a pro
High complexity cellular models such as three-dimensional (3D) spheroids better mimic in vivo environments compared to simpler two-dimensional (2D) models. While the development of quan…
Flyer
MetaXpress 6 Software
MetaXpress 6 Software
Reimagine your current workflow with MetaXpress® High-Content Image Acquisition and Analysis Software. The latest layout simplifies plate acquisition setup by consolidating key function…
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Flyer
Neurite Outgrowth Application Module
Neurite Outgrowth Application Module
Explore the Neurite Outgrowth Application Module for MetaXpress software, which is designed for the analysis of neurite outgrowth assays
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Brochure
Imaging Solutions to Answer Your Biological Questions
Imaging Solutions to Answer Your Biological Questions
Learn about our imaging family and which solution is best suited to answer your biological questions.
Videos and Demos
High-Content Screening for Identifying miRNAs
Identification of Selective Inhibitors of the STAT3 Signaling Pathway
Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging
Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System
Pushing the Boundaries of High Content Screening
Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy
Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes
High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models
Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events
Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes
Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids
Live Cell Imaging to Investigate the Regulation of Cell Division Timing
Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection
Application of HCA Tools for Antibody Drug Discovery
Setting up 3D Spheroid Assays Using High-Content Imaging
Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery
Related Products & Services of MetaXpress High-Content Image Acquisition and Analysis Software
Featured Applications
Angiogenesis Tube Formation
Angiogenesis Tube Formation Application Module facilitates the analysis of tube formation, a model…
Cell Cycle
Cell Cycle Application Module classifies and quantifies cells in various stages of the cell cycle…
Cell Health
Cell Health Application Module classifies cells states in viable, early apoptosis, late apoptosis…
Cell Proliferation High-Throughput
Cell Proliferation HT Application Module is a high throughput version of the Count Nuclei, (about 1…
Cell Scoring
Cell Scoring Application Module is a general and flexible solution to identify subpopulations of…
Count Nuclei
Count Nuclei Application Modules automate accurate counting of nuclei for most types of cells and…
Granularity and Transfluor
Granularity and Transfluor Application Module facilitate the analysis of punctate structures such…
Live/Dead
Live Dead Application Module is compatible with commercially available Live/Dead assay kits…
Micronuclei
Micronuclei Application Module classifies cells based on nuclear morphology for genotoxicity…
Mitotic Index
Mitotic Index Application Module is designed for the quantitative discrimination of mitotic and…
Monopole Detection
Monopole Detection Application Module monitors the disruption of the formation of bipolar spindles…
Multi-Wavelength Cell Scoring
Multi-Wavelength Cell Scoring Application Module enhances the functionality of the Cell Scoring…
Multi-Wavelength Translocation
The Multi-Wavelength Translocation Application Module lets you analyze the translocation of up to 6…
Neurite Outgrowth
Neurite Outgrowth Application Module is designed to measure and characterize outgrowths, the…
Nuclear Translocation High-Throughput
Nuclear Translocation HT Application Module is for the fast analysis of translocation in and out of…
Transfluor High-Throughput
Transfluor HT Application Module is a high throughput version of the Granularity Application Module…
Translocation and Translocation-Enhanced
Translocation and Translocation-Enhanced Application Modules quantify the correlation between…
Customer Breakthrough
SUCCESS STORY
HCS Pharma uses ImageXpress Micro Confocal Systems for phenotypic screening of physiologically relevant 3D cell models
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