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Implementing 3D neural spheroids in drug discovery: phenotypic screening & compound profiling using structural & functional assays

Due to the structural and functional complexity of the Central Nervous System (CNS), the ability to obtain accurate and predictive in vitro models for drug discovery and toxicology screening has been lacking. To fill this gap, StemoniX® has developed the microBrain® 3D platform: pre-plated neural spheroids composed of human iPSC-derived cortical neurons and astrocytes of uniform composition and size.

This presentation will detail how the FLIPR® Penta High-Throughput Cellular Screening System and the ImageXpress® Micro Confocal High-Content Imaging System have been used to functionally and structurally characterize microBrain 3D spheroids from both healthy and disease sources.

 

Implementing 3D neural spheroids in drug discovery