Eliminate 50/60 Hz line-frequency noise in less than one second

The HumSilencer® feature of the Axon™ Digidata® system learns, adapts, and eliminates local 50/60 Hz line-frequency noise patterns and associated high-frequency harmonics from incoming signals on up to four channels in parallel.

Humsilencer-Electrophysiological Applications

About this eBook:

A major challenge within electrophysiology research is 50 or 60 Hz line frequency electrical noise, which can either distort or completely drown out the biological signal the researcher is attempting to acquire. Methods for tackling this problem already exist but are either slow and inefficient or run the risk of themselves distorting the data.

In this eBook, you’ll learn how the HumSilencer feature within the Axon™ Digidata® 1550A/B Series Low-Noise Data Acquisition System provides a quick, adaptive method to remove excess noise across a range of electrophysiological applications, without distorting the data.

Sample pages

HumSilencer elimination of 60 Hz line-frequency noise

Electrical noise removed

HumSilencer quickly adapts to changing noise conditions

Adapting to changes in noise patterns

Single Channel Recording

Single-channel recording

Extracellular field potential recording

Extracellular field-potential recording

HumSilencer action potentials

Discriminating between signal and noise

Eliminate 50/60 Hz line-frequency noise in less than one second

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Learn more about the Axon Instruments® portfolio:

Axon Instruments Patch-Clamp Amplifiers

Patch-clamp amplifiers from single channel, whole-cell, and two electrode recordings

  • Control via pCLAMP software maximizes flexibility in setting up and performing different experimental protocols
  • A wide range of amplifiers means we can offer the ideal choice for your application, providing the best possible data
  • Our lowest-noise amplifier/digitizer instruments provide the highest signal resolution, and eliminate 50 or 60 Hz line-frequency noise contamination

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The Axon™ Digidata® 1550B plus HumSilencer®

High-resolution, low-noise digitizer with 50/60 Hz line-frequency noise elimination

In Carta
  • High rate of sampling (500kHz) means a more faithful digitization process, allowing for precise digital reconstruction of the analogue signal due to minimal information loss
  • Eight channels can be sampled and digitized simultaneously, increasing data acquisition speed
  • The HumSilencer option with the Digidata range eliminates of 50 and 60Hz line-frequency noise, making the biological signal clearer without distorting the data

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pCLAMP 11 Software Suite

A complete workflow solution for patch-clamp electrophysiology

  • Enhanced protocol editor in pCLAMP 11 Software allows for longer and more sophisticated protocols to be programmed and reduces protocol setup time
  • Multiple windows can be simultaneously displayed during a Membrane Test protocol, making it easier to patch multiple cells
  • Gap-free mode allows the programming of command and digital outputs in a continuous recording, allowing you to enhance protocol design and trigger actions within the protocol automatically

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