APPLICATION NOTE
All-optical assessment of long-term drug effects on human iPSC-derived cardiomyocytes
Increase assay robustness by tracking a drug’s chronic effect on cardiac function over extended periods of time
In this application note, we demonstrate an in vitro model using iPSC-CMs constantly expressing a genetically encoded calcium indicator for monitoring cell responses to various compounds for an extended period of time (up to 60 days). In addition, an optogenetic actuator was used to pace the cardiomyocytes in a noninvasive and reversible manner, mimicking a physiological steady rhythm. This contactless control and recording of cardiomyocytes cannot be easily achieved through conventional electrical stimulation.
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All-optical assessment of long-term drug effects on human iPSC-derived cardiomyocytes
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