APPLICATION NOTE
Structural organization and functional analysis of compound response in 3D human iPSC-derived cardiac tri-culture microtissues
Tri-culture model provides a novel tool for evaluation of functional and morphological effects on cardiac cells.
Recent publications show that tri-cellular co-culture microtissues of cardiomyocytes, endothelial cells and cardiac fibroblasts that are all derived from human iPSC enhance the maturation and functional activity of cells compared to 2D cardiomyocytes and thus more closely mimics actual heart physiology.
In this application note, we highlight the utility and biological relevance of using iPSC-derived cell types in 3D micro-tissues as a promising model for measuring compound effects on human cardiac tissues in a high-throughput format.