Supporting the global research community working on COVID-19
We understand what a challenging time this is for our customers who are working to get accelerated testing and medicines to the market as soon as possible. We are committed to supporting scientists that are researching COVID-19 cellular response and vaccine development. Our technology and solutions include microplate readers, washers, biopharma, and cellular imaging systems to meet your research needs. In addition, we offer tools to help assure validation and compliance in keeping with regulatory guidelines including FDA 21 CFR Part 11.
Our customers are developing potential therapies for COVID-19 including:
- Vaccines
- Recombinant proteins, including monoclonal antibodies
- Repurposing of drug molecules already approved, or in clinical trials, for other viruses
- Developing diagnostic and research tools using antibodies
Applications related to COVID-19 and critical research
Learn more about how our technology can help support your research of COVID-19 cellular responses and vaccine development. We’ll address common applications used in infectious disease research including ELISAs and cell line development to Viral Pathways and offer resources to aid in your research.
Coronavirus vaccine research:
- Cell Count/Cell Viability
- Cell Line Development
- Protein/Antigen Binding Affinity
- Protein/Nucleic Acid Quantification (Non-specific)
- Protein/Nucleic Acid Quantification (Specific)
- Viral Neutralization
- Viral Pathogenesis (Viral Pathways)
- Viral Titer
Vaccine development workflow
Vaccine development workflows vary depending upon the platform (e.g. inactivated virus vs. DNA vaccine) chosen, each having its own advantages. In order to increase the likelihood of success against the infectious agent, CEPI, the Coalition for Epidemic Preparedness Innovations, and many other organizations promote diverse approaches during a pandemic.
We’ve created a variety of virus-related workflows – from antigen/immunogen and antibody discovery to stable cell line development. Below is a general workflow for vaccine development using recombinant proteins as the immunogen, referencing the systems to aid in your research.
- Screen for binding to virus-specific immunogen – Screen virus-specific immunogens through binding using phage display
- Immunogen Characterization – Characterize lead immunogen candidates
- Protein (immunogen) Engineering – Optimize lead immunogen sequence and structure to enhance anti-viral function
- Cell Transfection and Cloning – Introduce lead immunogen sequence into cells for protein expression
- Screen for Quality Attributes, including Titer – Screen transfected cells to identify clones with high protein yield and desired quality attributes
Systems to accelerate your COVID-19 research
Get up and running rapidly with proven technologies
Molecular Devices is able to support your research needs by offering technology and solutions rapidly with express processing, shipping and customized finance solutions if needed on microplate readers, biopharma and cellular imaging systems.
Our ImageXpress systems offer an end-to-end solution for high-content screening and analysis. All our systems support a wide range of applications, increased throughput, and streamlined workflows.
Our SpectraMax® series of microplate readers measure absorbance, fluorescence, and luminescence plus additional detection modes with available upgrades for western blot, cell imaging, and fast kinetics with injectors. GMP/GLP labs can meet FDA guidelines with our SoftMax Pro GxP compliance and validation solution.
SoftMax® Pro 7.1.1 GxP Software is the latest, most secure software to achieve full FDA 21 CFR Part 11 compliance with streamlined workflows to ensure data integrity. Every step is optimized to simplify analysis and reporting to support our microplate readers.
The QPix™ 400 Series Microbial Colony Pickers combine intelligent image analysis with precise automation for fast and efficient screening of large libraries. Capable of picking up to 3000 colonies per hour, it will streamline your workflow.
The ClonePix™ 2 Mammalian Colony Picker is a fully automated system for the selection of high-value clones used in antibody discovery and cell line development.
The CloneSelect™ Single-Cell Printer™ Series deposits single cells gently and with high efficiency using a patented, inkjet-like disposable, one-way dispensing cartridge.
The CloneSelect™ Imager is a high-throughput automated solution for imaging and analyzing mammalian cells.
Our washers provide speed and configurability options—from single-tube dispensing to washing full 96- and 384-well plates.
Related News & Articles
Imaging system from Molecular Devices helps Recursion produce the largest publicly available set of human cellular morphological data for COVID-19 therapeutic research
Technology Networks Spotlight
The Science Explorer interviews Justin Dranschak from Molecular Devices to discuss how we are supporting COVID-19 scientists in their analysis of immunology, candidate vaccines, therapeutics, and diagnostics.
Other great resources
Resources related to COVID-19 cellular responses and vaccine development
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Citations
Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays
Quantification of SARS-CoV-2 neutralizing antibody by wild-type plaque reduction neutralization, microneutralization and pseudotyped virus neutralization assays
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Detect SARS-CoV-2 IgG in serum samples with a luminescent immunoassay
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Measure viral-induced cytopathic effects with a quantitative luminescence assay
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Comparison of traditional cloning methods vs. CloneSelect Single-Cell Printer f.sight using CHO cell lines commonly used for monoclonal antibody production
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Validate CRISPR-Edited Cells using Imaging and Western Blot Detection on a Microplate Reader
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Visualize subcellular vesicles to quantitate autophagy in neuronal cells
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Increase sensitivity in no-wash assays using confocal imaging
Increase sensitivity in no-wash assays using confocal imaging
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Detection and quantitation of protein with ScanLater Western Blot Detection System
Detection and quantitation of protein with ScanLater Western Blot Detection System
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Measuring luciferase expression using the SpectraMax Glo Steady-Luc Reporter Assay Kit
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Nucleic acid quantitation and analysis using the QuickDrop Spectrophotometer
Nucleic acid quantitation and analysis using the QuickDrop Spectrophotometer
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