MetaXpress High Content Image Acquisition & Analysis Software
The premier image acquisition and analysis software for high-content screening, enabling both novice and expert users to set up hundreds of assays using a simple, intuitive interface.
High Content Screening (HCS) requires users to capture high-resolution images, recognize and segment objects, extract features, and then reduce this information into meaningful data. The MetaXpress® Software brings image acquisition and analysis under a common platform to streamline the HCS workflow.
The MetaXpress Software is ready for HCS. With an easy-to-use acquisition wizard and the fastest autofocus, virtually any sample can be set up and acquired in minutes. The pre-packaged image analysis application modules help both novice and expert users set up hundreds of assays. These application modules can be complimented by the MetaXpress® PowerCore™ High Content Image Processing Software to accelerate image analysis speed, make sure image analysis is never a bottleneck in the race to identify "hits", and meet the needs of the biggest multi-instrument facilities. Data transfer within the HCS workflow is facilitated by multiple integrated tools such as robotic integration, management of image and data files with the MDCStore™ Data Management Solution and data QC, visualization, and mining with the AcuityXpress™ Software.
Built upon the industry leading MetaMorph® Software, the MetaXpress Software incorporates over 25 years of experience with cellular techniques and workflows. This enables going beyond the general limitations of classic software and including advanced image acquisition and analysis methods to any screen to make sure any assay can be automated even if it requires live cells, time-lapse studies, fluid addition, multi-dimensional acquisition, 3-D reconstruction, and more.
Image acquisition protocol wizard provides fast and simple acquisition by stepping you through the image acquisition process and its optimization.
- Objective and sample selector lets you choose from a wide variety of supported objectives and samples. To make sure you can visualize unique phenotypes, MetaXpress Software supports objectives from 1 to 100X with the highest numerical aperture and allows you to set up acquisition of virtually any sample on any plate with SBS footprint or on microscope slides.
- Interactive display of sites to easily configure acquisition sites and capture rare events using optimal settings.
- Industry-leading laser autofocus provides the fastest focusing available to compensate for focus drift produced by temperature fluctuations, gravity, viscosity changes in immersion media, vibration, plate irregularities, and biological variability.
- Adaptive acquisition algorithm decreases sample read times on difficult, heterogeneous samples by acquiring a desired number of cells before moving on to the next well.
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| MetaXpress Software features a single protocol wizard to customize your HCS workflow |
All the features and journaling functions of the MetaMorph Software to customize and automate image acquisition and analysis ─ unattended execution of complex multi-step routines including any hardware control or image analysis feature can be set up with journals, which do not require the user having to know a programming language. This ensures that any research imaging assay can be automated for high content screening. Examples of customization are extensive and some examples are given below.
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One can zoom-in on the heart of a Zebrafish to analyze its heartbeat. |
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One can image the blood circulation in Zebrafish and calculate veinous and arterial blood flows. |
Modular toolbox for image analysis with the application modules enabling both novice and expert users to set up hundreds of assays routinely used in high content screening without compromising the mature algorithms required to address their complex or emerging applications.
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| MetaXpress Software Application Modules enable hundreds of assays and are all customizable with journals. |
Learn More about the MetaXpress Application Modules.
Integration to a complete high content analysis workflow to handle the high content screening data deluge.
- MDCStore Data Management Solution is the key to ensuring that all imaging data generated is securely stored and fully accessible from the first image acquired, to years of usage.
- AcuityXpress Software reduces the time it takes to interpret high content screening data with the unique ability to connect data to the original images, integrating the high content screening workflow to high end data analysis and visualizations tools.
- MetaXpress® PowerCore Software harnesses the power of parallel processing to analyze images faster than they are acquired, thereby eliminating image analysis bottlenecks.
