Bringing you our latest discoveries in high-throughput screening, genomic and cellular analysis, colony selection, and microplate detection. Visit us at: moleculardevices.com
New collaboration announcement
We are pleased to announce our new collaboration with HeartBeat.bio, a biotech company developing cardiac organoids for drug discovery.
With cardiovascular diseases the leading cause of death worldwide, and cardiotoxicity a leading cause of drug withdrawals, this collaboration will provide automated solutions to better model disease physiology, discover novel drugs, and test pre-clinical candidates for cardiac toxicity using 3D cell cultures. In addition, the commercialized offering will enable researchers to reliably scale production of cardioids and advance cardiac drug discovery, and will be compatible with our Organoid Innovation Center solutions available today.
AI-enabled phenotypic analysis of label-free intestinal organoids
The intestinal crypt system is an important part of the intestinal organoid where mature organoids have more complex and numerous crypt structures. Yet, due to their high turnover rate and rapid renewal, monitoring their growth and maturation can be difficult.
In this application note, we describe methods for using high-content imaging and analysis to define and measure changes in phenotypes and the morphology of organoids.
We also share a workflow to easily image, analyze, and classify intestinal organoids using an AI-enabled classification approach to monitor growth and development of the organoids in culture. These methods can be applied to any organoid, regardless of the origin or development protocols.
This new landing page provides an overview of how organoid models empower researchers to better mimic the in vivo environment, obtain more physiologically-relevant data and ultimately bring life-saving therapeutics to market – faster.
Our imaging, analysis and automation solutions enable you to scale up your organoid research, and ultimately move to a truly high-throughput screening workflow.
By partnering with us, you can quickly, accurately and efficiently characterize organoids, obtaining the consistent, reliable and physiologically-relevant data you need to proceed with confidence.
Optimized workflow for rapid identification of neutralizing antibodies against viral particles
Rebecca Kreipke, PhD | Biopharma Field Applications Scientist, Molecular Devices.
In this webinar, we demonstrate the steps from clonal selection to cell growth tracking to image-based assurance of monoclonality.
The image-based monoclonality report is then generated to be included in the global licensing applications such as the Biologics License application (BLA) to the US Food and Drug Administration (FDA).
Enjoy 50% off a CloneSelect Single Cell Printer f.sight or c.sight for a limited time
The CloneSelect® Single-Cell Printer™ Series deposits single cells gently and with high efficiency using a patented, inkjet-like disposable, one-way dispensing cartridge. Sort cells using high-res imaging in bright-field or optional fluorescence and capture five images per single cell deposit. Prove monoclonality, improve your efficiency, maintain and enrich your viability, and prevent cross-contamination.
In this podcast, we cover ELISA assays, their advantages and automation with experts Dr. Ana Miletic, Senior Research Scientist and Anna Dey, Senior Research Associate at Kyowa Kirin, as well as Dr. Cathy Olsen, Senior Applications Scientist at Molecular Devices.
Listen now to discover how ELISA assays work, why they are highly sensitive and how they are used within our experts’ research, plus much more!
Key points discussed:
How ELISA assays can support a wide range of research in drug discovery and development
Advantages of ELISA assays compared to other immunoassays
What kind of instrumentation is used for ELISA assays and what elements of an automation platform are most critical for success
Rapidly assess drug response in breast cancer model systems with a luminescent viability assay
For many years, two-dimensional (2D) cell culture involving cells grown in a monolayer on a flat culture surface has served as a convenient system for investigating disease mechanisms and assessing the effects of potential new drugs.
In this application note, we demonstrate how our SpectraMax® iD5 Multi-Mode Microplate Reader can provide:
Rapid assessment of cell viability in 3D cultures
Highly sensitive luminescent readout
Easy 3D cell culture and assay setup in U-bottom microplates
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