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| NEW |
| On-demand Webinars |
| Urban myths of microplate readers |
In this unique, new, five-part on-demand webinar series, we’ll introduce you to various aspects of microplate reader technology in an educational and entertaining way!
Starting with some basic concepts, we’ll explain a number of ‘urban myths’ or misconceptions in each webinar—as well as introduce a variety of theories and technologies—ultimately enabling you to fully understand the choices you make when writing protocols, choosing a new plate reader, or optimizing an existing assay. |
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| NEW |
| Lab Notes Blog |
| Advancing scientific discovery to improve quality of life |
We’re pleased to introduce Lab Notes, our new blog dedicated to scientific discovery. Stay up to date on the latest technology trends and gather valuable tips and techniques that will help advance your research journey.
Featured posts:
- Advancing scientific discovery to improve quality of life
- Water immersion technology and high-content imaging: A closer look
- Get to know Kayla Hill, our Field Applications Scientist
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| NEW |
| Customer Spotlight |
| ApresLabs use SpectraMax® readers to revolutionize research into pesticide resistance |
Dr. Graham Moores at ApresLabs Ltd in the UK is revolutionizing research into pesticide resistance by identifying synergists that can reduce the need for prolonged or excessive insecticide usage, as well as being pollinator- and environmentally- friendly.
Find out why he has been using SpectraMax plate readers for over 30 years. |
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| NEW |
| Application Spotlight |
| Development of optimized workflows to enable calcium mobilization assays on the SpectraMax iD3 and iD5 readers |
| Discover how the SpectraMax iD3 and iD5 Multi-Mode Microplate Readers, equipped with dual injector systems, can be used to develop information-rich, fluorescence-based assays to monitor intracellular calcium changes. |
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| NEW |
| Infographic Spotlight |
| History of ELISA from Creation to COVID-19 Research |
| ELISA (enzyme-linked immunosorbent assay) is a method used to quantitatively detect an antigen within a sample. An antigen is a toxin or other foreign substance, for example a flu virus or environmental contaminant, that causes the vertebrate immune system to mount a defensive response. Check out our new infographic to learn more about this method and its history, from creation to COVID-19 research. |
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| NEW |
| Video Spotlight |
| Data analysis with pCLAMP 11 software |
| The Axon™ pCLAMP™ 11 Software Suite is the most widely-used electrophysiology data acquisition and analysis program for control and recording of voltage-clamp, current-clamp, and patch-clamp experiments. The software suite consists of Clampfit 11 software with Automated Event Detection and Advanced Batch Analysis macros which eliminate the need to define parameters for every set, streamlining data analysis. |
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| NEW |
| Product Spotlight |
| Complete compliance solutions for GMP/GLP labs |
| Our microplate detection systems and software combined with software installation and validation services assure data integrity and compliance in GMP/GLP labs, in accordance with FDA 21 CFR Part 11 guidelines. |
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| NEW |
| On-demand Webinar |
| 3D cell culture, tissue clearing, & high-content imaging in the quest of effective solutions to NAFLD |
Here, we present a case study for integrating novel 3D cell culture, tissue clearing, and high-content imaging techniques to better identify therapeutic solutions to non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH).
- Increase assay sensitivity and viability using Primary Human Hepatocytes (PHH) pre-qualified for spheroid formation
- Apply tissue clearing techniques to fully characterize 3D cell culture models in a single workflow
- Utilize water immersion objectives and targeted acquisition with confocal imaging to fully characterize 3D fibrosis models in a high-throughput manner
- Perform 3D volumetric analysis and other custom analyses for unique feature extraction and quantification
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| NEW |
| On-demand Webinar |
| Disease modeling in the 21st century: Automated organoid assays with 3D imaging |
Here, we present a workflow which integrates the Protein Fluidics’ Pu•MA System for automated organoid assays with our ImageXpress® Micro Confocal High-Content Imaging System.
- Automate media exchange, sampling, and staining of complex 3D systems such as spheroids, organoids, and tumoroids
- Acquire high quality images at high-throughput with water immersion objectives
- Measure and analyze calcium oscillations in neuro-spheroids using the FLIPR® Penta High-Throughput Cellular Screening System
- Perform 3D volumetric analysis and other custom analyses for phenotypic characterization of compound effects
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| NEW |
| Poster Spotlight |
| 3D imaging and analysis of angiogenesis in the organ-on-a-chip platform |
- Visualize angiogenic sprouting and 3D reconstitution of structures using the ImageXpress Micro Confocal System with water immersion objectives
- Perform quantitative assessment of angiogenesis, including number of sprouts, total volume, and average intensity
- Generate physiologically-relevant results using the MIMETAS OrganoPlate® platform
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| NEW |
| Application Spotlight |
| Quantification of spheroid growth and morphology - a fast and simple approach for compound screening |
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There is a growing trend to develop screening assays using three-dimensional (3D) cell culture. A common approach is to grow cells within an extracellular matrix allowing greater interaction with neighboring cells and more complex structure formation.
In this application note, we describe a simple assay to assess cytotoxicity of chemotherapeutic agents on a human colorectal carcinoma cell line. This method delivers an easy and fast approach for quantifying spheroid growth and gross morphological characteristics. Structures can be detected using a fluorescent nuclear stain and analyzed using the CellReporterXpress® Image Acquisition and Analysis Software to assess summary-level (per well) and population-level information. |
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| Join our team |
| Ready to reach your full potential? Click here to see what life is like at Molecular Devices. |
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