Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6

Bourhis, E., et al., 19 (10), 1433-1442, Structure, 2011

In this study, the Octet system is used to characterize the interactions between the E1 domain of the Wnt coreceptor LRP6 and its consensus binding sequence, a motif found in Wnt inhibitors that bind to LRP5/6. The effects of motif point substitutions on motif-LRP6 E1 binding affinities are characterized using BLI.

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