Vaccine-Induced HIV-1 Envelope gp120 Constant Region 1-Specific Antibodies Expose a CD4-Inducible Epitope and Block the Interaction of HIV-1 gp140 with Galactosylceramide

Dennison SM, et al., 88(16):9406-17, J Virol, 2014

The researchers presented data characterizing vaccine-induced antibodies that potentially block HIV-1 Env- galactosylceramide (Galacer) binding by perturbing HIV-1 Env conformation. Antibody identification was done using artificial membranes containing synthetic Galacer and recombinant HIV-1 Env proteins. Binding studies were performed on the Octet RED96 with Aminopropylsilane (APS) biosensors.

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