TMEFF2 is a PDGF-AA Binding Protein with Methylation-Associated Gene Silencing in Multiple Cancer Types Including Glioma

Lin, K., et al., 6(4), e18608, PLoS ONE, 2011

TMEFF2 is a protein containing a single EGF-like domain and two follistatin-like modules. The biological function of TMEFF2 remains unclear with conflicting reports suggesting both a positive and a negative association between TMEFF2 expression and human cancers. Here the authors report that the extracellular domain of TMEFF2 interacts with PDGF-AA. Octet platform binding assays were performed to validate the results obtained by ELISA, confirming presence of specific binding between TMEFF2 and PDGF-AA.

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