Therapeutic Effect of IVIG on Inflammatory Arthritis in Mice is Dependent on the Fc Portion and Independent of Sialylation or Basophils

Campbell IK, et al, 192(11):5031-8, J Immunol, 2014

The authors performed intravenous IG (IVIG), a common treatment for different chronic and acute autoimmune and inflammatory diseases and demonstrated in two different mouse inflammatory arthritis models that IVIG was protective in a dose-dependent manner and that the protective activity was contained within the Fc fragment and not the F(ab′)2 fragments. The integrity of the lectin-purified Fc molecules and their binding ability was confirmed on the Octet QK platform, along with ELISA experiments.

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