The Sclerostin-bone Protein Interactome

Devarajan-Ketha, H., et al., 417 (2), 830-835, Biochemical and Biophysical Research Communications, 2012

This publication identifies a large number of bone-derived protein binding partners of sclerostin, an important regulator of osteoblastic activity. The authors use the Octet system to determine the dissociation constant for sclerostin-carbonic anhydrase II binding. The assay used Super Streptavidin biosensors with biotinylated carbonic anhydrase II.

Read More