The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) is Druggable

Benod C, et al., 9(6):e99440, PLoS One, 2014

In this study, the authors performed structural and functional analysis identifying three novel small molecules (ccrp 1, ccrp 2 and ccrp 3) that bind Tailless (TLX), a Human orphan nuclear receptor previously thought to have no ligands and therefore was difficult to characterize. The binding studies were carried out on the Octet RED384 system using Super-Streptavidin (SSA) biosensors. The results demonstrated that the ligands bind to TLX, and they enhance TLX repressive actions thereby providing insight into characterizing the receptor and dissecting TLX dependent regulatory pathways.

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