Talin-bound NPLY Motif Recruits Integrin-signaling Adapters to Regulate Cell Spreading and Mechanosensing

Pinon P, et al., 205(2):265-81, J Cell Biol, 2014

The authors examined the functional activities of integrin protein as it relates to cell adhesion and cell spreading activity by monitoring binding and complex formation after performing mutational analysis on a targeted cytoplasmic sequence motif of the protein. Binding analysis was performed on the Octet RED384 system using Ni-nitrilotriacetic acid (NTA) biosensors.

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