Susceptibility to HLA-DM is determined by a dynamic conformation of major histocompatibility complex class II molecule bound with peptide

Yin L, et al., pii: jbc.M114.585539, J Biol Chem, 2014

The researchers performed mutational and functional analysis to demonstrate how the non-classical MHCII protein DM (HLA-DM) acts as a conformational editor to mediate the exchange of peptides loaded onto MHCII molecules during antigen presentation, a key step in the control of adaptive immune responses. Binding studies were performed on the Octet QK system and Streptavidin biosensors were used.

Read More