Structure of Vaccinia Virus A46, an Inhibitor of TLR4 Signaling Pathway, Shows the Conformation of VIPER Motif

Kim Y, et al., doi: 10.1002/pro.2472, Protein Sci, 2014

In this report, the authors performed a detailed study on the specific interactions and binding characteristics of the vaccinia virus protein A46 to better understand the role of this protein in interfering with Toll receptor binding and the host immune response system. Binding analysis was performed on the Blitz system using Ni-NTA biosensors.

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