Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases

Zhang, M, et al., 21(4), 680-688, Structure, 2013

The protein Cerebral Cavernous Malformation 3 (CCM3) can heterodimerize with GCKIII kinases, including MST4. This study presents structural and functional studies of the CCM3-MST4 heterodimeric complex. Interactions between wild-type or mutant MST4 and wild-type or mutant CCM3 were quantified using the Octet RED96 system. Biotinylated CCM3 variants were loaded onto Streptavidin biosensors for these experiments.

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