Structural Correlates of Antibodies Associated with Acute Reversal of Amyloid beta-related Behavioral Deficits in a Mouse Model of Alzheimer Disease

Basi, G.S., et al., 285(5), 3417-3427, Journal of Biological Chemistry, 2010

The authors study three antibodies that target the same epitope of amyloid-beta peptide, but differ in their ability to reverse amyloid-beta-related behavioral deficits in transgenic mouse models. The Octet system was used for kinetic characterization of antibody binding to soluble myeloid percursor protein. Various antibodies were immobilized using Goat Anti-Mouse biosensors, and then incubated with different concentrations of soluble myeloid percursor protein.

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