Strategic Selection and Development of Immunogenicity Binding Methods

Menendez, A.T. , 4(12), 1491-508, Bioanalysis, 2012

This is a comprehensive review on development of a robust program for immunogenicity testing. New detection technologies with applications in immunogenicity are discussed, including the Octet platform, its capabilities and advantages of label-free technology. The author also describes different assay formats for immunogenicity testing, preparation and storage of critical reagents, feasibility studies, and optimization and validation methods.

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