Strategic Approaches for Assessment and Minimization of Matrix Effect in Ligand-binding Assays

Shih JY, Patel V and Ma M, 6(8):1103-12, Bioanalysis, 2014

The article examined the potential causes of matrix effects that potentially impact and influence the results of ligand binding assays when quantitating large molecule analytes in biological matrices. Understanding better the root causes of the matrix effect will allow for improved experimental design and data analysis. Binding studies were performed on the Octet RED384 system and Streptavidin biosensors were used.

Read More