Specificity for Human Hemoglobin Enhances Staphylococcus aureus Infection

Pischany, G., et al., 8, 544-550, Cell Host Microbe, 2010

Iron is required for bacterial proliferation and S. aureus steals this metal from host hemoglobin during invasive infections. The authors demonstrate an enhanced ability of S. aureus to bind hemoglobin derived from humans as compared to other mammals. The Octet QK system was used to characterize staphylococcal hemoglobin receptor IsdB-hemoglobin binding affinity using Streptavidin biosensors loaded with biotinylated hemoglobin.

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