Small-molecule Modulation of Wnt Signaling via Modulating the Axin-LRP5/6 Interaction

Wang S, et al., 9(9), 579-85, Nat Chem Biol, 2013

This study investigated the use of small molecules to modulate the differential assemblies of Axin and, therefore, modulate Wnt signaling. Binding kinetics and affinities of small molecule-Axin interactions were determined using the Octet Red system. Biotinylated Axin domains were loaded onto Super Streptavidin biosensors for the interaction studies.

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