Signaling of High Mobility Group Box 1 (HMGB1) Through Toll-like Receptor 4 in Macrophages Requires CD14

Kim S, et al. , 19, 88-98, Molecular Medicine, 2013

The authors report that CD14 is required for activation of TLR4-dependent signaling by HMGB1, and that this occurs in association with CD14, TLR4 and MD2 accumulation within lipid rafts. The Octet QK system was used to characterize the binding of various recombinant proteins and antibodies to HMGB1, which was covalently immobilized on Amine Reactive biosensors.

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